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Entry Level Trial Master File Specialist Jobs (NOW HIRING)

Cellectis

Clinical Trial Associate

Manhattan, NY · On-site

$36.75 - $50.25/hr

This role contributes to the maintenance of inspection-ready trial documentation and systems, including the Trial Master File (TMF/eTMF) and Clinical Trial Management System (CTMS), in compliance ...

Cellectis

Clinical Trial Associate

Manhattan, NY · On-site

$36.75 - $50.25/hr

This role contributes to the maintenance of inspection-ready trial documentation and systems, including the Trial Master File (TMF/eTMF) and Clinical Trial Management System (CTMS), in compliance ...

StartX

Clinical Trial Associate

Redwood City, CA · On-site

$41 - $56/hr

Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs, the TMF Reference Model, and applicable regulatory requirements, including ICH-GCP. * Help ensure ...

StartX

$24.75 - $33.75/hr

Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs, the TMF Reference Model, and applicable regulatory requirements, including ICH-GCP. * Help ensure ...

Kaygen

Spec 3, Clinical Research

Irvine, CA · On-site

... Specialist supports all phases of clinical studies, including study start-up, conduct, and closeout, with a primary focus on maintaining an audit- and inspection-ready Trial Master File (TMF). This ...

Karius

Clinical Trial Associate

Redwood City, CA · On-site +1

$41 - $56/hr

Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs, the TMF Reference Model, and applicable regulatory requirements, including ICH-GCP. * Help ensure ...

Karius, Inc.

$24.75 - $33.75/hr

Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs, the TMF Reference Model, and applicable regulatory requirements, including ICH-GCP. * Help ensure ...

Karius, Inc.

Clinical Trial Associate

Redwood City, CA · On-site

$41 - $56/hr

Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs, the TMF Reference Model, and applicable regulatory requirements, including ICH-GCP. * Help ensure ...

Three Point Solutions

MN · On-site

$40 - $41/hr

Manage and maintain contract documentation and upload required files to the Trial Master File ... Provide guidance or support to entry-level team members when required Must Have * Bachelor's degree ...

Medpace, Inc.

Entry-Level TMF Administrator

Cincinnati, OH · On-site

$32.25 - $44/hr

The Trial Master File (TMF) is a collection of documents that stores all data and research collected on a given trial. The TMF allows us to conduct a clinical trial and ensures data integrity. It is ...

Medpace, Inc.

Entry-Level TMF Administrator

Cincinnati, OH · On-site +1

$32.25 - $44/hr

The Trial Master File (TMF) is a collection of documents that stores all data and research collected on a given trial. The TMF allows us to conduct a clinical trial and ensures data integrity. It is ...

Ergclinical

$25.75 - $34.50/hr

The TMF Specialist supports Regulatory Operations by managing, reviewing, and approving site-level ... Review, process, and approve Trial Master File (TMF) documents submitted to the electronic TMF ...

Vanguard Clinical

Clinical Operations Associate (Pool)

CA · Remote

$70K - $80K/yr

... Trial Master File Management, Clinical Monitoring, Quality Assurance, Data Management and Study ... This is an exciting entry-level opportunity to join a fast-paced and dynamic learning environment ...

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Entry Level Trial Master File Specialist information

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How much do entry level trial master file specialist jobs pay per hour?

As of Sep 14, 2026, the average hourly pay for entry level trial master file specialist in the United States is $20.24, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $21.88 per hour, depending on experience, location, and employer.

What is an entry level trial master file specialist?

An Entry Level Trial Master File (TMF) Specialist is responsible for organizing, maintaining, and ensuring the accuracy and completeness of clinical trial documentation. They work closely with clinical research teams to manage essential documents required by regulatory authorities throughout the lifecycle of a clinical trial. This role is crucial for compliance and helps ensure that all trial documentation is audit-ready and meets industry standards. Entry level specialists typically handle document filing, tracking, quality control checks, and support for audits or inspections.

What are the key skills and qualifications needed to thrive as an entry level trial master file specialist, and why are they important?

To thrive as an Entry Level Trial Master File Specialist, you need strong organizational skills, attention to detail, and a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management tools, and Good Clinical Practice (GCP) guidelines is typically required. Effective communication, time management, and a proactive attitude help you excel in maintaining documentation accuracy and supporting clinical teams. These skills are crucial for ensuring regulatory compliance and smooth clinical trial operations.

What are some common challenges faced by entry level trial master file specialists, and how can they overcome them?

Entry Level Trial Master File (TMF) Specialists often encounter challenges such as managing large volumes of clinical trial documents, ensuring compliance with strict regulatory guidelines, and maintaining accurate records in a fast-paced environment. To overcome these challenges, it's important to develop strong organizational skills, become familiar with relevant regulations like ICH-GCP, and proactively communicate with team members to clarify document requirements. Utilizing available training resources and seeking mentorship from experienced colleagues can also help new specialists adapt quickly and succeed in their role.

What is the difference between Entry Level Trial Master File Specialist vs Clinical Trial Coordinator?

AspectEntry Level Trial Master File SpecialistClinical Trial Coordinator
Primary ResponsibilitiesManaging and organizing trial master files, ensuring document complianceOverseeing trial operations, coordinating site activities, and managing schedules
Required CredentialsHigh school diploma or equivalent; some roles may prefer a degree in life sciencesBachelor's degree in life sciences or related field
Work EnvironmentOffice-based, working with regulatory documents and electronic systemsOffice and site visits, interacting with study teams and sites
Industry UsageCommonly used in clinical research organizations and pharmaceutical companiesUsed across clinical research sites and sponsor companies

While both roles support clinical trials, the Entry Level Trial Master File Specialist focuses on document management and compliance, whereas the Clinical Trial Coordinator handles overall trial operations and site coordination. Understanding these differences helps candidates choose the right career path in clinical research.

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Entry Level Trial Master File Specialist jobs near you
Infographic showing various Entry Level Trial Master File Specialist job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 88% Full Time, 8% Part Time, and 2% Contract. Highlights an 72% Physical, 2% Hybrid, and 26% Remote job distribution, with an average salary of $42,098 per year, or $20.2 per hour.

Clinical Trial Associate

Manhattan, NY • On-site

Cellectis
See more jobs at Cellectisexternal

$36.75 - $50.25/hr

Full-time

Re-posted 22 days ago

Job description


The Clinical Trial Associate (CTA) supports clinical study teams in the execution and oversight of clinical trials under the direction of the Vice President, Development Operations, with day-to-day guidance from the assigned Study Lead. The CTA plays a key role in study start-up, ongoing trial execution, and close-out activities, with a primary focus on document management, trial tracking, and operational support.
This role contributes to the maintenance of inspection-ready trial documentation and systems, including the Trial Master File (TMF/eTMF) and Clinical Trial Management System (CTMS), in compliance with applicable regulatory requirements (GCP/ICH), internal SOPs, and company standards.
All activities are conducted in accordance with company policies, SOPs, and corporate values.
POSITION RESPONSIBILITIES
Clinical Trial Support
  • Support study start-up activities, including site feasibility, investigator onboarding, and collection of regulatory and essential documents
  • Assist with site management activities throughout the trial lifecycle, from start-up through close-out
  • Communicate with clinical sites and vendors, as appropriate, to support timely collection of required documentation
  • Support investigational product tracking activities, including inventory documentation, shipment tracking, and reconciliation

Trial Documentation & Systems
  • Maintain accurate, complete, and inspection-ready Trial Master Files (electronic or paper)
  • Support ongoing maintenance of the Clinical Trial Management System (CTMS), ensuring data accuracy and timeliness
  • Review, file, and track clinical trial documentation in accordance with SOPs and regulatory requirements
  • Assist with quality control (QC) checks of study, country, and site-level documentation and support issue resolution

Study Tracking & Reporting
  • Maintain study trackers (e.g., regulatory submissions, site start-up timelines, protocol issue logs)
  • Track study progress and generate routine status reports and metrics as requested
  • Assist with review of monitoring visit reports (initiation, routine monitoring, and close-out)

Meetings & Cross-Functional Collaboration
  • Coordinate and support internal and external study meetings, including preparation of agendas, meeting minutes, and action item tracking
  • Collaborate with cross-functional teams, CROs, and vendors to support routine study operations
  • Provide general administrative and operational support to Development Operations team as needed

Compliance & Inspections
  • Support preparation for and follow-up on audits and regulatory inspections, as applicable
  • Assist with review of informed consent documents, case report forms, and other study-related materials

EDUCATION AND EXPERIENCE
  • Bachelor's degree (BS/BA) or equivalent preferred
  • Minimum of 1-3 years of experience supporting clinical trials, preferably in a pharmaceutical, biotechnology, or CRO environment

TECHNICAL SKILLS & CORE COMPETENCIES
  • Foundational knowledge of FDA and/or EMA regulations, ICH guidelines, and GCP requirements
  • Basic understanding of clinical trial documentation, filing structures, and operational workflows
  • Working knowledge of clinical systems such as eTMF, CTMS, and EDC platforms
  • Ability to manage multiple tasks and priorities in a fast-paced clinical development environment
  • Strong attention to detail and organizational skills
  • Proficiency in Microsoft Office applications (Word, Excel, PowerPoint)
  • Effective written, verbal, and interpersonal communication skills
  • Ability to work collaboratively across functions with appropriate supervision and guidance

Proposed Compensation Range: 80,000 - 90,000

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