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How much do entry level protein purification scientist jobs pay per hour?

As of Jul 20, 2026, the average hourly pay for entry level protein purification scientist in the United States is $33.06, according to ZipRecruiter salary data. Most workers in this role earn between $21.63 and $40.87 per hour, depending on experience, location, and employer.

What are some common challenges faced by entry level protein purification scientists, and how can they be overcome?

Entry level protein purification scientists often encounter challenges such as optimizing protocols for different proteins, troubleshooting unexpected results, and managing multiple experiments simultaneously. It is common to face issues with low protein yield or purity, which requires careful adjustment of buffer conditions and purification methods. Collaborating closely with experienced colleagues and utilizing detailed lab documentation can help overcome these hurdles. Additionally, proactively seeking feedback and participating in team meetings fosters continuous learning and improvement.

What does an Entry Level Protein Purification Scientist do?

An Entry Level Protein Purification Scientist is responsible for isolating and purifying proteins from various biological samples using techniques such as chromatography and centrifugation. They assist with preparing buffers and reagents, operating laboratory equipment, and analyzing samples for purity and concentration. Their work supports research, drug development, and manufacturing processes by ensuring proteins are available in the required quality and quantity for further study or production.

What is the difference between Entry Level Protein Purification Scientist vs Laboratory Technician?

AspectEntry Level Protein Purification ScientistLaboratory Technician
Required CredentialsBachelor's degree in Biochemistry, Molecular Biology, or related fieldBachelor's degree or associate degree in a science-related field
Work EnvironmentResearch labs, biotech companies, pharmaceutical firmsResearch, clinical, or industrial labs
Employer & Industry UsageUsed in biotech, pharma, research institutionsCommon in healthcare, research, manufacturing
Common Search & ComparisonOften compared for entry-level research roles involving protein workCompared for lab support roles in similar settings

While both roles work in laboratory settings and may require similar educational backgrounds, the Entry Level Protein Purification Scientist focuses specifically on isolating and analyzing proteins, often involving more specialized techniques. The Laboratory Technician typically supports various lab functions, including sample preparation and data recording, with a broader scope of responsibilities.

What are the key skills and qualifications needed to thrive as an Entry Level Protein Purification Scientist, and why are they important?

To thrive as an Entry Level Protein Purification Scientist, you need a solid background in biochemistry, molecular biology, or related fields, often supported by a bachelor's or master's degree. Familiarity with laboratory techniques such as chromatography, SDS-PAGE, and relevant analytical instruments, as well as experience with lab management software, is typically required. Attention to detail, problem-solving abilities, and effective teamwork are crucial soft skills for success in this role. These skills ensure accurate experimental results, efficient workflow, and reliable contributions to larger research or production goals.
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Entry Level Protein Purification Scientist jobs near you
Infographic showing various Entry Level Protein Purification Scientist job openings in the United States as of July 2026, with employment types broken down into 80% Full Time, and 20% Contract. Highlights an 100% In-person job distribution, with an average salary of $68,765 per year, or $33.1 per hour.
Research Scientist I - Protein Sciences and Structural Biology

Research Scientist I - Protein Sciences and Structural Biology

Broad Institute

Cambridge, MA • On-site

$88K - $124K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago

New

Job description

General information
Location
Cambridge, MA
Ref #
44535
Job Family
Research
Date published
07/14/2026
Time Type
Full time
Pay Range
$88,000.00/yr - $124,000.00/yr
Description & Requirements
Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to explore drug discovery projects in a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, high content imaging, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients.
We are seeking a passionate and highly motivated Research Scientist I to join CDoT's Protein Technologies team. The successful candidate will have a solid understanding of protein construct design, expression, purification, and quality assessment. Experience in structural biology is advantageous.
Principle Duties and Responsibilities:
  • Developing and executing strategies to clone and express recombinant proteins in a variety of expression systems
  • Purifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)
  • With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinement
  • Initiating and completing routine protein construct design and production in an independent and efficient manner
  • Demonstrating the ability to interpret experimental outcomes and proposing follow-up studies
  • Troubleshooting and solving scientific problems related to protein production independently
  • Operating and maintaining lab equipment independently, including protein purification systems like an AKTA pure
  • Investigating new technologies related to protein expression and purification
  • Documenting work and effectively presenting results in cross-functional project teams

Requirements:
  • Ph.D in Biophysics, Biochemistry, Molecular Biology, Structural Biology or related life science field with 0-2+ years of research experience in an industrial or academic setting
  • Expertise in recombinant protein purification using chromatography (affinity, ion exchange, and size exclusion)
  • Significant experience with cloning and expressing proteins using different vectors, tags, and various cell culture systems (mammalian, insect, bacterial, yeast)
  • Significant experience with protein characterization (analytical size exclusion chromatography, mass spectrometry, light scattering, western blot and biophysical binding studies)
  • Experience in protein crystallography and crystallographic data processing, model refinement, and structural analysis is a plus
  • Experience with biophysical characterization of proteins (ITC, DSC, SPR, NMR etc.) is a plus
  • A proven record of successful interaction with project team members, external customers or vendors

The successful candidate will be a results-focused, team-oriented, creative bench scientist able to excel in a fast-track environment. She or he must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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