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How much do downstream purification lead jobs pay per hour?

As of Sep 13, 2026, the average hourly pay for downstream purification lead in the United States is $26.43, according to ZipRecruiter salary data. Most workers in this role earn between $18.99 and $31.01 per hour, depending on experience, location, and employer.

What does a downstream purification lead do?

A Downstream Purification Lead oversees the purification processes in biopharmaceutical manufacturing, ensuring that proteins or other biological products are efficiently separated and purified after initial production. They manage teams, troubleshoot process issues, implement improvements, and ensure compliance with industry regulations and quality standards. Their role is critical for delivering high-purity products for clinical or commercial use, and they often collaborate with upstream production, quality control, and regulatory teams.

What are the key skills and qualifications needed to thrive as a downstream purification lead?

To thrive as a Downstream Purification Lead, you need expertise in bioprocess engineering, protein purification techniques, and a relevant degree in biotechnology, biochemistry, or a related field. Familiarity with chromatography systems, filtration technologies, and regulatory compliance (such as GMP) is crucial, along with experience using laboratory information management systems (LIMS). Strong leadership, problem-solving abilities, and effective communication help manage teams and resolve process challenges efficiently. These skills are vital to ensure high-yield, high-purity product output while maintaining safety and compliance in biomanufacturing environments.

What are some common challenges faced by a downstream purification lead, and how can they be addressed?

A Downstream Purification Lead often faces challenges such as maintaining process consistency, troubleshooting equipment issues, and ensuring product quality under tight timelines. Balancing multiple projects and adapting to evolving regulatory requirements can also be demanding. Effective solutions include rigorous documentation, proactive communication with upstream and analytical teams, and ongoing training in emerging purification technologies. Building strong cross-functional relationships and fostering a culture of continuous improvement can help navigate these complexities successfully.

What are popular job titles related to Downstream Purification Lead jobs?

For Downstream Purification Lead jobs, the most frequently searched job titles are:

Infographic showing various Downstream Purification Lead job openings in the United States as of September 2026, with employment types broken down into 88% Full Time, 10% Part Time, and 2% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $54,972 per year, or $26.4 per hour.

Downstream Purification Scientist, MSAT, New Mfg. Facility

Lebanon, IN • On-site

Eliassen Group
IT Services • 5 - 10K employees
Learn more about Eliassen Groupexternal

$65 - $75/hr

Contractor

Medical, Dental, Vision, Life, Retirement

Re-posted 21 days ago

Key responsibilities

  • Provide technical support for downstream MSAT technology transfer activities.

  • Support manufacturing floor activities and provide technical troubleshooting as needed.

  • Support documentation activities and review/approve manufacturing and technical documentation.

Job description

Description:

On-site in Lebanon, IN

Our client seeks a Downstream Purification Scientist to provide technical leadership and execution support for downstream purification activities associated with gene therapy drug substance manufacturing. The role supports technology transfer, process implementation, manufacturing readiness, and documentation for clinical and commercial production. The position supports documentation activities and frontline manufacturing operations and reports to the Head of Advanced Therapies at the site.

Due to client requirements, applicants must be willing and able to work on a w2 basis. For our w2 consultants, we offer a great benefits package that includes Medical, Dental, and Vision benefits, 401k with company matching, and life insurance.

Rate: $65.00 to $75.00/hr. w2

Responsibilities:
  • Provide technical support for downstream MSAT technology transfer activities.
  • Lead and facilitate discussions related to process lock, process optimization, and unit operation finalization.
  • Prepare, review, and provide technical input to manufacturing and technical documentation.
  • Author, review, and approve Master Batch Records (MBRs) and Electronic Batch Records (EBRs).
  • Track MBR/EBR development status, progress, and turnaround timelines.
  • Support Operational Readiness Plan deliverables for the manufacturing site.
  • Serve as the downstream purification representative during internal, global, and external partner meetings.
  • Support manufacturing floor activities and provide technical troubleshooting as needed.
  • Identify technical issues, process deviations, and project risks, escalating concerns appropriately to management.
  • Provide timely communication regarding critical manufacturing or project issues.
  • Support continuous improvement initiatives while ensuring compliance with cGMP requirements.
Experience Requirements:
  • Previous MSAT experience supporting downstream purification processes for gene therapy or mAb/large molecule manufacturing.
  • Experience within pharmaceutical manufacturing and GMP-regulated environments.
  • Experience supporting commercial manufacturing processes and developing Master Batch Records.
  • Working knowledge of cGMP data integrity principles, including ALCOA+ requirements.
  • Demonstrated project management skills with the ability to manage priorities and meet timelines.
  • Strong technical writing, communication, and documentation skills.
Education Requirements:
  • Bachelor's, Master's, or Ph.D. in Chemical Engineering, Biochemistry, Biology, or Biotechnology.
Recruitment Transparency Notice
 
Eliassen Group values transparency in our recruitment practices. Please be advised that Eliassen Group utilizes artificial intelligence (AI) tools as part of its initial application screening and hiring process. You may receive email and SMS notifications from the Eliassen Virtual Recruiting Team (noreply@eliassen.com, 781-808-2924) inviting you to complete a brief voice screening as part of your application process. These tools assist our hiring teams in different ways, including but not limited to, assistance in reviewing application materials to help identify candidates whose qualifications most closely match the requirements of the position. All AI-assisted evaluations and responses are reviewed by human recruiters before any hiring decisions are made. The use of AI in our process is intended to support fairness, efficiency, and consistency, and Eliassen Group takes measures to prevent bias or discrimination in connection with its hiring practices. By proceeding, you acknowledge, agree, and consent to Eliassen Group’s use of these tools, including AI tools, as part of the application and hiring process.
 

Skills, experience, and other compensable factors will be considered when determining pay rate. The pay range provided in this posting reflects a W2 hourly rate; other employment options may be available that may result in pay outside of the provided range.W2 employees of Eliassen Group who are regularly scheduled to work 30 or more hours per week are eligible for the following benefits: medical (choice of 3 plans), dental, vision, pre-tax accounts, other voluntary benefits including life and disability insurance, 401(k) with match, and sick time if required by law in the worked-in state/locality.If anyone reaches out to you about an open position connected with Eliassen Group, please ensure that you are working directly with us by confirming the following:

· When you work with Eliassen Group, all email communication will come from an Eliassen.com address, never Gmail, Yahoo, etc.

· Eliassen Group will never ask you for personal information (home address, bank account, or check routing number) until you have worked with someone clearly associated with Eliassen Group.

If you have any indication of fraudulent activity, please contact fraud@eliassen.com.

 
About Eliassen Group:
 
Eliassen Group is a strategic consulting firm that helps organizations reach further and achieve more through our technology, business advisory, and life sciences solutions. For nearly 40 years, we have combined exceptional people, deep domain expertise, and intelligent capabilities to expand our clients’ capacity and accelerate meaningful outcomes. We are driven by a purpose to positively impact the lives of our employees, clients, consultants, and the communities we serve.
 
Eliassen is committed to building a diverse and inclusive team from a variety of backgrounds, perspectives, and skills. We are an Equal Opportunity and Affirmative Action Employer and all employment decisions are based on merit, performance, and business needs. Eliassen does not discriminate on the basis of race, color, gender identity or expression, sexual preference or orientation, sex (including pregnancy, childbirth, and related medical conditions), marital status, creed, religion, physical or mental disability, genetic information, military or veteran status, age, ancestry, national origin, citizenship status, prohibited criminal record inquiries of applicants and employees, or any other category protected by federal, state, or local laws.
 
Don’t miss out on our referral program! If we hire a candidate that you refer us to then you can be eligible for a $1,000 referral check!
 
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About Eliassen Group

Sourced by ZipRecruiter

Eliassen Group provides strategic consulting and talent solutions to drive our clients' innovation and business results. Our purpose is to positively impact the lives of our employees, clients, consultants, and the communities in which we operate. Leveraging over 30 years of success, our expertise in talent solutions, life sciences consulting, Agile consulting, cloud services, risk management, business optimization, and managed services enables us to partner with our clients to execute their business strategy and scale effectively. Headquartered in Reading, MA, and with offices from coast to coast, Eliassen Group offers local community presence and deep networks, as well as national reach.

Industry

It services

Company size

5,001 - 10,000 Employees

Headquarters location

Reading, MA, US

Year founded

1989

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