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Associate Director Purification information

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$30.5K

$102.7K

$173K

How much do associate director purification jobs pay per year?

As of Sep 13, 2026, the average yearly pay for associate director purification in the United States is $102,728.00, according to ZipRecruiter salary data. Most workers in this role earn between $70,000.00 and $141,000.00 per year, depending on experience, location, and employer.

What does an associate director purification do?

An Associate Director of Purification oversees the development, optimization, and operation of purification processes in biopharmaceutical manufacturing. This role typically involves managing teams responsible for the purification of proteins, antibodies, or other biologics, ensuring processes meet regulatory standards and production goals. They collaborate with other departments, troubleshoot issues, and drive continuous improvement efforts. Additionally, they play a key role in technology transfer, process validation, and ensuring compliance with Good Manufacturing Practices (GMP).

What key skills and qualifications are needed to thrive as an associate director purification?

To thrive as an Associate Director Purification, you need advanced expertise in protein purification, process development, and a degree in biochemistry, chemical engineering, or a related field—often at the Ph.D. level. Familiarity with large-scale chromatography systems, filtration technologies, and regulatory compliance (such as cGMP) is crucial, along with experience in data analysis tools. Strong leadership, problem-solving, and cross-functional communication skills set outstanding candidates apart in this role. These capabilities ensure the efficient development and scaling of purification processes, regulatory adherence, and successful management of teams and projects in biopharmaceutical manufacturing.

What are some typical challenges an associate director purification faces when scaling up purification processes from lab to manufacturing?

Associate Directors of Purification often encounter challenges such as ensuring process consistency and product quality during scale-up, managing cross-functional communication between R&D and manufacturing teams, and troubleshooting unexpected impurities or yield loss at larger scales. They must also navigate regulatory requirements and validate new equipment or procedures. Strong project management and problem-solving skills are essential, as is the ability to lead teams through complex technical transfers while meeting tight timelines.

What is the difference between Associate Director Purification vs Senior Scientist Purification?

AspectAssociate Director PurificationSenior Scientist Purification
CredentialsAdvanced degree (PhD/MSc), extensive industry experienceMaster's or PhD, significant laboratory experience
Work EnvironmentLeadership role overseeing teams and projectsHands-on laboratory research and process development
Employer UsageBiotech and pharmaceutical companies, managing purification processesResearch-focused roles within same industries
Search IntentLeadership, project management, strategic oversightTechnical expertise, experimental work

The Associate Director Purification typically holds a leadership position with strategic responsibilities, overseeing purification teams and projects. In contrast, the Senior Scientist Purification focuses more on technical research and process development. Both roles require advanced degrees and industry experience, but their focus and scope differ significantly.

What are popular job titles related to Associate Director Purification jobs?

For Associate Director Purification jobs, the most frequently searched job titles are:

Infographic showing various Associate Director Purification job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 67% Full Time, 29% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 96% Physical, 1% Hybrid, and 3% Remote job distribution, with an average salary of $102,728 per year, or $49.4 per hour.

Associate Director/Director, Protein Sciences

Bothell, WA • On-site

SystImmune, Inc
Biotechnology Research and Development • 1 - 10 employees
Learn more about SystImmune, Incexternal

$180K - $240K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 26 days ago

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
We are seeking an Associate Director or Director of Protein Sciences to lead antibody target protein expression, purification, and characterization in support of oncology biologics programs from early discovery through IND-enabling activities. This role will build and lead a team responsible for delivering high-quality protein material in functionalized formats suitable for evaluation of monoclonal, bispecific, and multi-specific antibodies and ADC-ready molecules, and will partner closely with Protein Engineering, Antibody Discovery, Analytical Sciences, and external partners to advance programs from concept to candidate selection and IND submission.
The ideal candidate brings deep hands-on expertise in mammalian protein expression, purification of protein complexes, and biophysical characterization, structural biology along with strong scientific judgment and people leadership skills. This individual will serve as a technical and operational hub for critical protein production across the discovery portfolio, ensuring that molecule quality, structural reagent relevance, and timelines meet the needs of fast-moving oncology programs. A key aspect of this role is enabling antibody structural and functional characterization through protein target engineering and rigorous characterization.
This role is full-time onsite at our Bothell, WA location.
Responsibilities
  • Lead and manage the Protein Sciences group, including hiring, mentoring, performance management, and career development of scientists and research associates
  • Serve as the target protein science subject-matter expert on cross-functional program teams; present strategy, results, and risk assessments to senior leadership
  • Lead the Protein Sciences function responsible for end-to-end protein production workflows, including construct design, transient and stable mammalian expression (HEK293, CHO), high-throughput and preparative purification, and quality control
  • Direct purification process development for complex membrane proteins, nano-disc, and multi-molecule complexes, resolve antibody bindings site, PPI site occlusions and functional site prediction.
  • Establish and oversee biochemical and biophysical characterization capabilities (SEC, HPLC/UPLC, CE-SDS, cIEF, DSF/DSC, SPR/BLI, mass spectrometry) to confirm identity, purity, stability, and binding
  • Design and implement automation, high-throughput screening workflows, and structured data capture to increase departmental capacity, quality, and reproducibility
  • Stay current with advances in protein engineering, expression technologies, and analytical methods, and champion adoption of new technologies where they add value

Qualifications
  • Ph.D. in biochemistry, protein chemistry, molecular biology, bioengineering, or a related field; M.S. or B.S. with commensurate additional experience will be considered
  • 8+ years (Director) or 6+ years (Associate Director) of relevant industry experience in biologics discovery and development
  • 3+ years of people-management experience leading scientists in a protein sciences, protein production, or biologics discovery setting
  • Deep hands-on expertise in mammalian expression systems and multi-modal antibody purification (Protein A/L, ion exchange, HIC, SEC, mixed-mode)
  • Demonstrated experience producing and characterizing complex biologics, including:
  • Membrane proteins
  • Dimer and heterodimer complexes
  • Engineered molecules for proving PPI and antibody binding sites
  • Strong working knowledge of biophysical characterization techniques and data interpretation (SPR/BLI, SEC-MALS, DSF/DSC, mass spectrometry, capillary electrophoresis)
  • Proven track record of advancing molecules from discovery through candidate selection and supporting IND-enabling activities
  • Excellent scientific judgment, communication, and cross-functional collaboration skills, with the ability to operate effectively in a fast-paced, milestone-driven environment

Preferred Qualifications
  • Familiarity with high-throughput automation platforms (liquid handlers, parallel purification systems) and structured data capture (ELN/LIMS)
  • Experience in oncology biologics and understanding of tumor-targeting antibody design principles
  • Mandarin-English Bilingual Ability
  • Prior contribution to regulatory filings (IND/IMPD) and interactions with process development or quality organizations

Core Competencies
  • Scientific rigor with strong operational execution
  • Team leadership and talent development
  • Cross-functional collaboration and influence
  • Technical problem-solving and troubleshooting
  • Agility in a dynamic R&D environment
  • Strong sense of ownership and accountability

Success in this role will be defined by the ability to:
  • Deliver high-quality protein reagents and candidate molecules on program timelines
  • Build and develop a scalable, high-performing Protein Sciences team and infrastructure
  • De-risk candidate molecules through rigorous characterization and developability assessment
  • Build trust across functions as a strategic and operational partner

Position Type/Expected Hours of Work
  • May need to work outside of standard working hours at times
  • This role is currently working onsite and is expected to work onsite for working hours, with flexibility to work start time. The work location for this role is in Bothell, WA

Compensation and Benefits
The expected base salary range for this position is $180,000 - $240,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's level qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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