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Downstream Process Jobs in Lowell, MA (NOW HIRING)

AT Process Technologies

Process Chemist

Waltham, MA · On-site

$130K - $200K/yr

Develop and optimize core synthesis and downstream processing, evaluating competing technical pathways and justifying key decisions using experimental results, process modeling, cost, and scale-up ...

Sartorius

Process Technology Engineer

Marlborough, MA · On-site

$95 - $120/hr

R40424Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle--from customer discovery through project execution.

New

Integrated Resources INC

Biprocess Engineer

Devens, MA · On-site

The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation ...

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

Merck Group

Senior Bioprocess Engineer

Burlington, MA · On-site

$113K - $156K/yr

Drawing on your deep expertise in downstream processing, you will monitor industry trends, engage with the scientific community, and represent the organization at conferences to stay at the forefront ...

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Repligen

Scientist II

Waltham, MA

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

RepliGen Corporation

Scientist II

Waltham, MA · On-site

$113.60 - $163.30/hr

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

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Downstream Process information

See Lowell, MA salary details

$13

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How much do downstream process jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for downstream process in Lowell, MA is $24.47, according to ZipRecruiter salary data. Most workers in this role earn between $19.57 and $27.88 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Lowell, MA?

For Downstream Process jobs in Lowell, MA, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Lowell, MA look for?

The top searched job categories for Downstream Process jobs in Lowell, MA are:

What cities near Lowell, MA are hiring for Downstream Process jobs?

Cities near Lowell, MA with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Lowell, MA as of August 2026, with employment types broken down into 1% As Needed, 79% Full Time, 12% Part Time, 5% Temporary, and 3% Contract. Highlights an 86% Physical, 8% Hybrid, and 6% Remote job distribution, with an average salary of $50,896 per year, or $24.5 per hour.

Laboratory Technician II

Artech Information System LLC

Framingham, MA • On-site

$19.50 - $26/hr

Contractor

Re-posted 6 days ago

Job description

Company Description

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.

Job Description

Job Description:

Join a team dedicated to supporting purification development and other activities within Late Stage Process Development (LSPD), Biologics R&D. The Department of Purification Development is responsible for the development and implementation of new downstream processes and technologies and for the provision of technical support to the GMP downstream process operations.

Responsibilities:

- Work independently under general supervision and direction. Work is reviewed for overall adequacy and accuracy.

- Operate complex lab equipment and execute experiments as per written or verbal instructions.

- Prepare buffer solutions or chemicals as needed.

- Prepare and sterilize laboratory equipment for operation.

- May involve work with hazardous materials. On the job training will be provided.



Qualifications

Skills:A general knowledge of purification laboratory procedures, equipment and terminology. Should be able handle multiple tasks simultaneously. Able to carry out tasks according to verbal and written instructions. Demonstrated interpersonal skills and effective communication skills required. Demonstrated ability to operate and care for laboratory equipment. Requires physical demands of lifting up to 20-25 pounds

Education:Requires a minimum BS degree with 3-6 years of experience in a scientific laboratory setting or MS degree.



Additional Information

Best Regards,

Anuj Mehta

973-967-3402




 


Artech logo

About Artech

Sourced by ZipRecruiter

Artech is a leading IT staffing and consulting company based in Morristown, NJ, US. Since its foundation in 1992, Artech has mastered in complementing human expertise with technology and business acumen to produce world-class staffing solutions. The company caters to diverse industry sectors, including financial services, healthcare, telecommunication, energy and utilities, supply chain, and retail. It provides IT consulting, project management, professional and staff augmentation, and managed staffing services. Artech's mission is to provide exceptional IT staffing services to its clients by comprehending their business needs and then crafting a customized staffing strategy. Its notable achievement includes being recognized as one of the largest IT staffing companies in the U.S, according to Staffing Industry Analysts (SIA).

Industry

Recruiting and staffing services

Company size

10,000+ Employees

Headquarters location

Morristown, NJ, US

Year founded

1992

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