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Downstream Process Jobs in Virginia (NOW HIRING)

Lead development and optimization of polymerization and downstream processing technologies (extrusion, compounding, molding). * Translate laboratory discoveries into pilot and commercial-scale ...

Working knowledge of SAP Ariba Downstream (P2P, invoicing, etc.). * Familiarity with Ziphq or other procurement automation tools. * Strong understanding of end-to-end source-to-pay (S2P) processes.

Validation Engineer

Elkton, VA · On-site

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Validation Engineer

Elkton, VA · On-site

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Validation Engineer

Elkton, VA · On-site

$72K - $80K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Support API and integration testing by validating request and response behavior, error handling, data transformation logic, authentication or authorization behavior, and downstream processing ...

In depth understanding of ARIBA upstream and downstream processes * Knowledge of backend integration with ERP is required * Demonstrated skills in documenting current procurement processes and ...

In depth understanding of ARIBA upstream and downstream processes * Knowledge of backend integration with ERP is required * Demonstrated skills in documenting current procurement processes and ...

Senior Data Engineer

Reston, VA

$110K - $149K/yr

... processing, event-driven pipelines, data quality, lineage, and downstream consumption. They should be able to become productive quickly in a complex engineering environment, ask good questions, and ...

BIC Intake Specialist

Reston, VA · On-site

$72K - $99K/yr

Document accurately and effectively provide documentation from end users, business process rationales, and approvals received to date; notate requests appropriately for downstream processing ...

Showing results 41-60

Downstream Process information

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Virginia?

For Downstream Process jobs in Virginia, the most frequently searched job titles are:

What cities in Virginia are hiring for Downstream Process jobs?

Cities in Virginia with the most Downstream Process job openings:

Infographic showing various Downstream Process job openings in Virginia as of August 2026, with employment types broken down into 1% As Needed, 73% Full Time, 23% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution.

R&D Engineer/Scientist

AdvanSix

Chesterfield, VA • On-site

Other

Medical, Dental, Vision, Life, Retirement, PTO

This job post has expired 2 days ago. Applications are no longer accepted.


AdvanSix rating

7.1

Company rating: 7.1 out of 10

Based on 12 frontline employees who took The Breakroom Quiz

69th of 102 rated chemical manufacturers


Job description

AdvanSix plays a critical role in global supply chains, innovating and delivering essential products for our customers in a wide variety of end markets and applications that touch people’s lives, such as building and construction, fertilizers, plastics, solvents, packaging, paints, coatings, adhesives, and electronics. Our reliable and sustainable supply of quality products emerges from the vertically integrated value chain of our three U.S. based manufacturing facilities. AdvanSix strives to deliver best-in-class customer experiences and differentiated products in the industries of nylon solutions, chemical intermediates, and plant nutrients, guided by our core values of Safety, Integrity, Accountability and Respect.


Please view a short video about our company here, AdvanSix Video. For more information on AdvanSix, please visit our website at http://www.advansix.com


Why work at AdvanSix?

• We provide benefits that are industry competitive and focused on employee well-being

• Total Rewards program includes a competitive compensation, health, dental, vision & wellness programs, paid vacation, 401K with company matching, health savings programs, disability & life insurance, employee assistance program

• Tuition reimbursement for continued education, certifications, training, and development

• Work within a fast paced and innovative company, meeting passionate colleagues and partners with diverse backgrounds and experiences

Nylon Lead R&D Scientist (Polymer Chemistry & Process Technology Focus)

Position Summary

The Nylon Lead R&D Scientist serves as a technical leader driving polymer chemistry innovation and process technology advancement for nylon (polyamide) systems. This role is responsible for developing deep molecular-level understanding and translating it into robust, scalable process solutions that improve manufacturing performance, product quality, and cost competitiveness.

Secondary responsibilities include new product development (NPD) and commercialization aligned with business strategy, with a strong emphasis on accelerating research cycles through advanced data analytics and AI-enabled experimentation.


Core Responsibilities

1. Polymer Chemistry Leadership (Primary Focus)

  • Lead design and execution of polyamide synthesis reactions, including batch and continuous polymerization systems.
  • Develop deep understanding of structure–property relationships to tailor polymer performance for target applications.
  • Apply advanced analytical techniques (e.g., rheology, DSC, GPC, IR, NMR) to characterize materials and guide decision-making.
  • Drive innovation in polymer modification, copolymerization, and additive incorporation to enable differentiated products.
  • Serve as subject matter expert in polyamide chemistry, organic chemistry, and analytical chemistry across the organization.


2. Process Technology & Scale-Up (Primary Focus)

  • Lead development and optimization of polymerization and downstream processing technologies (extrusion, compounding, molding).
  • Translate laboratory discoveries into pilot and commercial-scale processes, ensuring consistency, yield, and cost efficiency.
  • Provide technical leadership in process modeling, troubleshooting, and process improvement initiatives.
  • Partner with plant, engineering, and production teams to:
  • Improve conversion efficiency, throughput, and energy intensity
  • Resolve process limitations and variability
  • Enable reliable and repeatable manufacturing performance
  • Apply statistical tools (Six Sigma, DOE) to drive process robustness and variability reduction.


3. AI-Enabled Experimental Design & Research Acceleration (Key Differentiator)

  • Leverage artificial intelligence (AI) and machine learning tools to:
  • Design optimized Designs of Experiments (DOE)
  • Identify critical variables and interactions faster than traditional approaches
  • Predict polymer properties and process outcomes
  • Develop and deploy data-driven experimentation frameworks to reduce research cycle time and increase success rates.
  • Integrate experimental data, process data, and analytical results into predictive models that guide decision-making.
  • Continuously improve R&D efficiency through:
  • Automated data analysis workflows
  • Digital lab tools and experiment tracking systems
  • Demonstrated history of using advanced analytics or AI methods to accelerate root cause analysis and experimental iteration cycles (aligned with structured DOE approaches observed internally).


4. New Product Development & Commercialization (Secondary Focus)

  • Lead development of new nylon materials and applications, from concept through commercialization.
  • Partner with marketing, commercial, and customer teams to translate voice-of-customer (VOC) into technical solutions.
  • Drive Stage-Gate execution for NPD projects, including:
  • Feasibility studies
  • Pilot validation
  • Scale-up and commercialization
  • Deliver differentiated products aligned with market needs and profitability targets.


5. Technical Leadership & Collaboration

  • Lead cross-functional teams across R&D, Process Engineering, Manufacturing, and Commercial organizations.
  • Mentor and develop scientists and engineers in polymer science and process technology disciplines.
  • Serve as a technical advisor for complex problem solving, including customer issues and plant challenges.
  • Contribute to intellectual property development, including patents and trade secrets.


Basic Qualifications

  • Ph.D. (preferred) or Master’s degree in Polymer Chemistry, Polymer Science, Materials Science, or Chemical Engineering.
  • 5+ years of experience in polymer R&D, with emphasis on polyamide (nylon) systems.
  • Demonstrated experience in:
  • Polymer synthesis and characterization
  • Process development and scale-up
  • Commercialization of new materials


Preferred Qualifications

  • Deep expertise in polyamide chemistry and polymerization processes.
  • Experience with polymer processing technologies (extrusion, compounding, molding).
  • Proven track record of leading successful R&D projects and delivering commercial outcomes.
  • Experience integrating AI/ML, advanced analytics, or digital tools into R&D workflows.
  • Six Sigma or statistical modeling experience for DOE and process optimization.
  • Strong communication and leadership skills with ability to influence stakeholders.


Success Profile

The ideal candidate will:

  • Lead with polymer chemistry depth and process technology rigor
  • Translate science into scalable, reliable manufacturing solutions
  • Use AI-driven experimentation to accelerate innovation cycles
  • Deliver measurable business impact through both process improvements and new product commercialization


The base salary range for this role is: $95,000 to $142,600 annually.


We offer a range of market-competitive total rewards that include periodic pay rate adjustments based on market competitiveness. Hired applicants will be eligible for paid holidays, paid time off including vacation, eligibility to purchase company stock, tuition reimbursement, and a 401K with a competitive company match. Certain roles may be eligible for discretionary financial benefits such as incentive pay, equity awards, and participation in a deferred compensation plan.

Hired applicants will be eligible for medical, dental and vision insurance, flexible spending and health savings account eligibility, employer-provided short term disability benefits, eligibility to purchase long term disability benefits, employer-provided basic life insurance and eligibility to purchase voluntary life coverages.


The pay range, incentives and benefits listed above are general guidelines only and not a guarantee of total compensation or benefits. The final offer will depend on multiple factors, including but not limited to, the responsibilities of the job, experience, education, knowledge, skills, and abilities, as well as the job location, applicability of a collective bargaining agreement, length of service, internal equity, and alignment with market data. The incentive pay is dependent on your role, business results and individual performance. All aspects of total rewards offered are subject to the terms and conditions of the specific plans.

At AdvanSix, we are dedicated to building a diverse, inclusive, and authentic workplace, so if you’re excited about this role but your past work experience doesn’t perfectly align with every qualification in the job posting, we encourage you to still apply. You may just be the right candidate for this or other roles.


AdvanSix is an equal opportunity employer. Qualified applicants will be considered without regard to age, race, creed, color, national origin, ancestry, marital status, affectional or sexual orientation, gender identity or expression, disability, nationality, sex, religion, veteran status, or any other protected classification.


To all agencies: Please, no phone calls or emails to any employee of AdvanSix about this opening. All resumes submitted by search firms/employment agencies to any employee at AdvanSix via-email, the internet or in any form and/or method will be deemed the sole property of AdvanSix, unless such search firms/employment agencies were engaged by AdvanSix for this position and a valid agreement with AdvanSix is in place. In the event a candidate who was submitted outside of the AdvanSix agency engagement process is hired, no fee or payment of any kind will be paid.


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