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Downstream Process Jobs in Kentucky (NOW HIRING)

Piramal Pharma Limited

Process Engineer

Lexington, KY · On-site

... downstream manufacturing events. • Recommends, justifies, demonstrates and implements new ... Presents ideas and suggestions for product and/or process, equipment improvements, improved ...

Eurofins

DNA Synthesis Technician I/II

Louisville, KY · On-site

Perform downstream oligo processing, including pre-treatment and deprotection * Learn to perform basic troubleshooting and minor fixes on oligo synthesizers * Use our proprietary LIMS (Laboratory ...

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Downstream Process information

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How much do downstream process jobs pay per hour?

As of Jul 28, 2026, the average hourly pay for downstream process in Kentucky is $21.43, according to ZipRecruiter salary data. Most workers in this role earn between $17.12 and $24.42 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Kentucky? For Downstream Process jobs in Kentucky, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Kentucky look for? The top searched job categories for Downstream Process jobs in Kentucky are:
What cities in Kentucky are hiring for Downstream Process jobs? Cities in Kentucky with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Kentucky as of July 2026, with employment types broken down into 18% Locum Tenens, 72% Full Time, 6% Part Time, 3% Contract, and 1% Summer. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $44,572 per year, or $21.4 per hour.
Downstream Processing Operator

Downstream Processing Operator

Danimer Scientific

Winchester, KY • On-site

$16.50 - $20.75/hr

Full-time

Medical, Dental, Vision, Retirement

Posted 29 days ago

Job description

Benefits:
  • 401(k)
  • 401(k) matching
  • Bonus based on performance
  • Dental insurance
  • Health insurance
  • Training & development
  • Vision insurance
  • Wellness resources

NOW INTERVIEWING FOR FUTURE OPPORTUNITIES:
Downstream Processing (DSP) Operator
Winchester, KY | Biodegradable Plastics
Schedule: 12 Hour Shifts on a 2-2-3 pattern (Day or Night Availability Required)
Employment Type: Non-exempt | Full-time
At Danimer Scientific, we're building the future of sustainable materials-and that takes skilled operators who care about quality, safety, and doing things the right way. As a Downstream Processing (DSP) Operator, you'll play a hands-on role in producing advanced materials in a cGMP manufacturing environment while working with a collaborative, safety-focused team.
If you enjoy technical work, problem-solving, and being part of a process that truly matters, we'd love to meet you.
What You'll Do
Under the guidance of a Team Leader and Manufacturing Management, the DSP Operator is responsible for executing day-to-day production activities in the Downstream Processing area. This role is hands-on, detail-oriented, and critical to maintaining product quality and process reliability.
Key Responsibilities Include:
  • Operate and monitor downstream processing equipment and utilities
  • Start/stop pumps, open/close manual valves, collect samples, and respond to process alarms
  • Monitor process conditions and adjust parameters to maintain stability
  • Accurately complete batch records, logbooks, and production documentation in compliance with cGMP standards
  • Review production documentation for accuracy, completeness, and quality compliance
  • Add chemicals and process additives based on calculations and procedures
  • Troubleshoot process or equipment deviations and initiate corrective actions
  • Communicate production metrics, issues, and shift handoffs clearly
  • Maintain clean, organized, and audit-ready work areas per GMP standards
  • Participate in continuous improvement initiatives related to safety, quality, and efficiency
  • Train and support new or developing operators
  • Serve as a safety leader-stop production when a quality or safety concern is identified

What We're Looking For
Required Qualifications
  • High school diploma or GED
  • Minimum of 2 years of experience in a manufacturing or industrial environment
  • Ability to work independently and as part of a team
  • Strong attention to detail and commitment to documentation accuracy
  • Mechanically inclined with strong problem-solving skills
  • Comfortable working with automated systems and manual equipment
  • Proficient with basic computer systems (Microsoft Suite)

Preferred Qualifications
  • Associate degree in applied process technologies or related field
  • Prior experience in biotech, chemical, or cGMP manufacturing
  • Working knowledge of GMP, safety protocols, and quality systems

Work Schedule
  • Full-time, 12-hour shifts
  • Days or nights, including weekends, holidays, and overtime as required

Physical & Work Environment Requirements
  • Ability to stand, walk, bend, stoop, and perform repetitive tasks for extended periods
  • Ability to lift up to 50 lbs occasionally and climb ladders/stairs
  • Work in hot, cold, loud, and industrial manufacturing environments
  • Use of PPE including hearing protection in designated areas
  • Exposure to moving mechanical parts, vibration, fumes, and airborne particles

Why Danimer?
Mission-driven work (bye, plastic pollution)
Growth opportunity
Great pay + benefits
Team-first culture
Equal Opportunity Employer
Danimer Scientific provides equal employment opportunities to all employees and applicants without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other status protected by law. We comply with all federal, state, and local laws governing nondiscrimination in every location where we operate.
We strictly prohibit any form of workplace harassment or discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, or any other protected status.
Apply now and be part of something bigger
We're advancing the future of sustainable materials - and we're not alone!
Our commitment to replacing traditional plastics with biodegradable, compostable solutions is now backed by a strong, new partnership with - a global leader in material science. Together, we're turning shared vision and shared values into real-world impact.
Join us as we celebrate a partnership that moves sustainability forward!

Apply