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Downstream Process Jobs in Delaware (NOW HIRING)

CAI

Validation Engineer

Wilmington, DE

$72.80K - $80.10K/yr

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

CAI

Validation Engineer

Wilmington, DE

... downstream processing - Purification, recovery - Building automation - Pharmaceutical manufacturing processes Critical Competencies Influence Strategy - Pursues initiatives aligned with ...

Computer Task Group, Inc

Software Engineer III

Wilmington, DE · On-site

$55.75 - $75/hr

... and downstream systems • Build and refactor REST/SOAP/file-based integrations (SFTP, batch processing) • Replace legacy SQL-based integrations with API-driven solutions • Develop modular ...

Capital One

Accounting Manager

Wilmington, DE

Throughout this project, you will have the ability to understand our current and future systems along with upstream and downstream processes that will impact these systems including line of business ...

Computer Task Group, Inc

Software Engineer III

Wilmington, DE · On-site

$55.75 - $75/hr

... and downstream systems • Build and refactor REST/SOAP/file-based integrations (SFTP, batch processing) • Replace legacy SQL-based integrations with API-driven solutions • Develop modular ...

Dlapiper

Data Engineer

Wilmington, DE · On-site

$111.10K - $133.40K/yr

... processes that translate raw data into trusted, usable datasets for analytics, reporting, and downstream solutions. The role focuses on operationalizing pipelines with governance and service ...

Valueprosite

senior java developer

Wilmington, DE

$55.50 - $70.75/hr

Designs, develops, codes, and troubleshoots with consideration of upstream and downstream systems ... Demonstrated knowledge of software applications and technical processes within a technical ...

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Downstream Process information

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Delaware? For Downstream Process jobs in Delaware, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Delaware look for? The top searched job categories for Downstream Process jobs in Delaware are:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Delaware as of May 2026, with employment types broken down into 2% Internship, 90% Full Time, 2% Temporary, 4% Contract, and 2% Nights. Highlights an 96% In-person, and 4% Remote job distribution.
Downstream Operations Scientist

Downstream Operations Scientist

University of Delaware

Newark, DE • On-site

Full-time

Posted 23 days ago

University Of Delaware rating

5.9

Company rating: 5.9 out of 10

Based on 18 frontline employees who took The Breakroom Quiz

486th of 530 rated colleges and universities

Job description

Downstream Operations Scientist
Job no: 502528
College / VP Area: Research Office
Work type: Staff
Location: Newark, DE
Categories: Research & Laboratory, Full Time
Curious about the full value of working at UD? In addition to salary, our Total Rewards benefits and Compensation Estimator give you a clear view of the complete package.
Pay Grade: 33E
Context of the Job:
The Downstream Operations Scientist is responsible for leading downstream purification unit operations for materials from bioreactors and shake flasks with culture volumes ranging from 250mL to 50L in scale at the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The work will involve 21CFR58 compliant downstream operations and data analysis, including utilizing automation systems. The scientist will also collaborate with bioreactor specialists and an analytical team.
Among other activities, NIIMBL executes technical projects that advance the readiness levels of relevant technologies, assays, and methods. The scopes of scientific projects generally include many organizations as partners and collaborators such as scientists from several large and small companies, a scientist from a Federal agency, and a scientist from a University. Many of these projects will be hosted at the University of Delaware in a state-of-the-art laboratory facility purpose-built for such studies. These projects will involve a diverse set of technologies and approaches and address drug substance, drug product, and analytical needs by the industry appropriate to several types of biopharmaceuticals: vaccines, therapeutic proteins and antibodies, antibody-drug conjugates, bispecific antibodies, gene therapy vectors, and cell therapies, among others.
Major Responsibilities
  • Serve as a lead technical scientist on multiple projects involving downstream purification unit operations for the manufacture of industrially relevant products and related activities.
  • Adhere to 21CFR58 GxP guidelines in execution of work.
  • Set-up, operate, troubleshoot, maintain, and clean downstream bioprocessing equipment.
  • Use manufacturing experience to identify process parameters and define their setpoints.
  • Perform DoE studies to confirm the impact of process parameters on impurity levels, product recovery, and potency.
  • Characterize performance of existing purification and formulation unit operations, including column chromatography (e.g., ProA, SEC, CEX, AEX), filtration, TFF, and bulk filling.
  • Develop new primary recovery unit operations such as centrifugation, homogenization, flocculation, tangential-flow filtration (TFF), and depth filtration.
  • Develop new chromatography unit operations, from screening and characterization to optimization and initial scale-up.
  • Optimize buffer compositions to improve the stability and solubility of target molecules.
  • Collaborate with an analytical team to adapt and troubleshoot research analytical methods such as HPLC, SDS-PAGE, enzyme activity and endotoxin assays to quantify yield, activity, and purity at various stages of the manufacturing process.
  • Document all work and analyses in an electronic lab notebook. Perform tracking and trend analysis of method performance.
  • Analyze process performance trends, perform statistical data analysis, and present data to teams.
  • Partner with Informatics Infrastructure team on deploying structured data capture systems.
  • Draft and revise SOPs and batch records.
  • Maintain detailed documentation of lab activities and tabulation of data.
  • Compile data generated to present and discuss at team meetings.
  • Author, review and edit technical reports and manuscripts intended for publication.
  • Stay current with relevant technologies and scientific literature.
  • Perform other job-related duties as assigned.

Qualifications:
  • A Masters in chemical engineering or relevant life science discipline and 5 years of industrially relevant downstream purification experience is required with preference for experience in a 21CFR58-compliant GxP environment, or a PhD in chemical engineering or relevant life science discipline and 2 years of industrially relevant downstream purification experience is required with preference for experience in a 21CFR58-compliant GxP environment.
  • Hands-on experience with a range of downstream unit operations and control systems, experience with DeltaV preferred.
  • Operates chromatography skids and other bioprocess equipment for purification of industrially relevant materials.
  • Knowledge of biotech manufacturing process and equipment including cell culture, depth and tangential flow filtration, column chromatography, protein purification and formulation and/or buffer and media operations.
  • Possess a contribution mindset fueled by an inner drive to take initiative without being directed.
  • Excellent interpersonal and managing skills with the desire to work collaboratively and effectively in a team environment.
  • Ability to demonstrate effective leadership through communication, respect, influence, persuasion, and trust.
  • Excellent problem solving and critical thinking skills.
  • Excellent writing, communication, and presentation skills.
  • Strong MS Excel, PowerPoint, and Word skills. Microsoft Project skills.
  • Excellent organization and planning skills.
  • Strong attention to detail and ability to adhere to standards procedures.
  • Ability to function in a rapidly changing environment.

Notice of Non-Discrimination and Equal Opportunity
The University of Delaware does not discriminate against any person on the basis of race, color, national origin, sex, gender identity or expression, sexual orientation, genetic information, marital status, disability, religion, age, veteran status or any other characteristic protected by applicable law in its employment, educational programs and activities, admissions policies, and scholarship and loan programs as required by Title IX of the Educational Amendments of 1972, the Americans with Disabilities Act of 1990, Section 504 of the Rehabilitation Act of 1973, Title VII of the Civil Rights Act of 1964, and other applicable statutes and University policies. The University of Delaware also prohibits unlawful harassment including sexual harassment and sexual violence.
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