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Downstream Process Development Jobs in Seattle, WA

SystImmune, Inc

Senior Scientist, Cell Science

Redmond, WA · On-site

$90K - $140K/yr

Collaborate with project teams and downstream process development scientists to execute protocols, experimental plans, critical production batches, and technology transfers. * Manage and prioritize ...

Syner-G

Vice President, Biologics

Seattle, WA · Remote

Provide expert guidance across biologics development including upstream and downstream process development, analytical characterization, drug substance and drug product manufacturing, and CMC ...

Meta

Supplier Development Engineer, Robotics

Redmond, WA · On-site

$173K/yr

... downstream integration (FATP). You will take ownership of the technical and operational ... Manufacturing Process Development: Develop optimized, scalable manufacturing processes for robotics ...

Meta

Supplier Development Engineer, Robotics

Redmond, WA · On-site

$173K - $245K/yr

... downstream integration (FATP). You will take ownership of the technical and operational ... Responsibilities Manufacturing Process Development: Develop optimized, scalable manufacturing ...

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Downstream Process Development information

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How much do downstream process development jobs pay per hour?

As of Sep 10, 2026, the average hourly pay for downstream process development in Seattle, WA is $38.33, according to ZipRecruiter salary data. Most workers in this role earn between $31.44 and $47.07 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What job categories do people searching Downstream Process Development jobs in Seattle, WA look for?

The top searched job categories for Downstream Process Development jobs in Seattle, WA are:

What cities near Seattle, WA are hiring for Downstream Process Development jobs?

Cities near Seattle, WA with the most Downstream Process Development job openings:

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Seattle, WA as of September 2026, with employment types broken down into 95% Full Time, and 5% Contract. Highlights an 66% In-person, 5% Hybrid, and 29% Remote job distribution, with an average salary of $79,731 per year, or $38.3 per hour.

Senior Scientist, Cell Science

Redmond, WA • On-site

SystImmune, Inc
Biotechnology Research and Development • 1 - 10 employees
Learn more about SystImmune, Incexternal

$90K - $140K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 15 days ago

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
The Senior Scientist in the Cell Science Department is responsible for the development and optimization of CHO-based processes for the production of biotherapeutics. This role requires broad expertise and the ability to contribute to both drug discovery and development projects. A strong interest in bench work and hands-on experience with mammalian cell culture is essential.
This position requires a full-time onsite presence at our Redmond, WA location.
Responsibilities:
  • Design and execute cell line development workflows, including vector design, transfection, clone screening, and selection for stable expression.
  • Perform cell culture experiments involving mammalian cells (e.g., CHO cells) under sterile, aseptic conditions.
  • Develop and optimize expression systems, including promoters, selection markers, and gene amplification strategies for high-yield production.
  • Screen and characterize clones for productivity, stability, growth characteristics, and product quality attributes using molecular and biochemical assays.
  • Collaborate with project teams and downstream process development scientists to execute protocols, experimental plans, critical production batches, and technology transfers.
  • Manage and prioritize multiple projects while supporting and coordinating with other departments to advance company objectives and develop scalable, robust culture processes.
  • Write and review Standard Operating Procedures (SOPs) and technical reports for regulatory filings.
  • Prepare process transfer documents and cGMP documentation to support the successful implementation of process technologies in clinical and commercial manufacturing operations.
  • Collaborate with R&D and the manufacturing team in China, participating in meetings and providing technical support as needed.
  • Availability to work weekend and holiday shifts, as required.
  • Perform other duties as assigned.

Qualifications:
  • Ph.D. in Cell Biology or a related field, with 5+ years of relevant experience in the pharmaceutical or biotechnology industry.
  • Strong scientific background in recombinant protein expression, cell line development, cellular metabolism, and media optimization.
  • Experience in both early- and late-stage bioreactor operations, mammalian stable cell line development, and upstream process development is preferred.
  • Demonstrated expertise in advanced technologies for cell line development, with a focus on antibody production.
  • Strong knowledge of FDA regulations and other global health authority requirements related to Investigational New Drug (IND) applications, particularly those concerning single stable clone selection and characterization.
  • Excellent written, verbal, and interpersonal communication skills.
  • Proven ability to perform effectively under pressure, meet tight deadlines, and adapt to shifting project priorities and requirements.
  • Experience with high-throughput automated workstations for clone selection is highly desirable.
Compensation and Benefits:
The expected base salary range for this position is $90,000 - $140,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

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