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How much do downstream process development jobs pay per hour?

As of May 30, 2026, the average hourly pay for downstream process development in Redmond, WA is $37.72, according to ZipRecruiter salary data. Most workers in this role earn between $30.96 and $46.30 per hour, depending on experience, location, and employer.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.
More about Downstream Process Development jobs
What are popular job titles related to Downstream Process Development jobs in Redmond, WA? For Downstream Process Development jobs in Redmond, WA, the most frequently searched job titles are:
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What cities near Redmond, WA are hiring for Downstream Process Development jobs? Cities near Redmond, WA with the most Downstream Process Development job openings:
Downstream Process Development jobs near you

Associate Director, Downstream Process Development

Zymeworks

Bellevue, WA • On-site

$146.25K - $224.25K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 28 days ago

Job description

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biotechnology company developing a diverse pipeline of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases, including cancer, inflammation, and autoimmune disease. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop antibody-based therapeutic candidates. We are a global company headquartered in Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, and Singapore.
Why Work With Us
Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.
This role will be located in Bellevue, WA and is hybrid with a minimum of 3 days per week onsite.
What You'll Do
  • Serves as a strategic manager for the company's downstream process development and production operations to drive program timelines.
  • Directs the strategic planning of downstream process development and manufacturing in support of all phases of clinical development including support of late clinical phase filings.
  • Collaborates within cross-functional teams (Research, Development, Clinical, Quality, Regulatory), to define and execute development strategies for novel biotherapeutics and ADCs.
  • Leads project-specific efforts in process development, scale-up, production and tech transfer of processes within and between CMOs.
  • Participates in the development of RFP's to solicit project specific bids from CMOs/CROs.
  • Develops SOWs defining work to be performed and provide subsequent oversight of experiments and activities conducted at the CMO/CRO.
  • Develops highly productive manufacturing processes in a timely manner for novel antibody, multispecific and ADC therapeutics. Brings issues to the attention of appropriate personnel as necessary.
  • Designs, manages and supports process characterization studies and develops control strategies for process validation.
  • Authors technical documents and deliver presentations to technical and project groups.
  • Contributes to the preparation and submission of CMC portions of regulatory submissions and updates (IND and BLA).
  • Works directly with Analytic Sciences, Manufacturing Sciences and Technology and Quality teams to plan and implement execution of downstream process development and manufacturing operations.
  • Ensures that all developed processes are compatible with quality requirements including regulations, policies, applicable guidelines and procedures.
  • Serves as primary point of contact with contract manufacturing organizations (CMOs) and performs person-in-plant duties as needed to provide technical support for ongoing manufacturing.
  • Provides technical support for all CMC activities, including investigations, CAPAs, Change Controls, technology transfers, operation and lifecycle management of pre-clinical and cGMP manufacturing processes, ensuring all product delivery schedules are met.
  • Authors and reviews technical CMC documentation, including protocols, technical reports, manufacturing batch records, SOPs, change controls and deviations.
  • Drives timely decisions and facilitates active communication and information flow between CMOs and Zymeworks team members.
  • Fosters strong, long-lasting cross-functional working relationships with internal and external CMC, Quality Assurance, Project Management, Clinical Operations, and external manufacturing entities to ensure successful development and manufacture of all products.
  • Promotes a culture of continuous improvement in product quality and productivity.
  • Works closely with all internal and external resources to ensure DS supply availability.

What You'll Bring
  • University degree in science or engineering and a minimum of 8 years related experience in biopharmaceutical process development and GMP operations or an equivalent combination of education and experience.
  • Experience working with contract manufacturing organizations.
  • Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional team. Ability to establish and maintain effective working relationships.
  • Excellent organizational skills and the ability to work effectively in a high paced, fast changing environment.
  • Consistent analytical reasoning ability.
  • Familiarity with QbD and Control Strategy Development or multivariate analysis and DoE approaches to process development a plus.
  • Strong background in the regulatory compliance requirements for the cGMP production of biologicals for clinical and commercial use.
  • Working knowledge of regulatory guidelines and expertise in CMC, PK or toxicology for the advancement of therapeutics through different phases of development.
  • Proficiency with cGMP and ICH guidelines.

Total Rewards
We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.
The base salary range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position in the location for which the job is posted and does not include bonus, equity, or benefits. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate's location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).
Our total rewards package that includes:
  • Industry leading vacation and paid time off
  • Exceptional medical, dental and vision benefits by country
  • Zymelife health and wellness benefits
  • Matching RRSP / 401K / Pension program
  • Employee Share Purchase Program
  • Employee Equity Program
  • Paid time off to volunteer in your community

This role is not eligible for relocation or immigration support.
All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.
NOTE TO AGENCIES: Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.
The pay range for this role is:
146,250 - 224,250 USD per year (US)

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