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Downstream Process Development Jobs in Boston, MA

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Downstream Process Development information

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How much do downstream process development jobs pay per hour?

As of Jun 9, 2026, the average hourly pay for downstream process development in Boston, MA is $36.59, according to ZipRecruiter salary data. Most workers in this role earn between $30.05 and $44.90 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Process Development position, and why are they important?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What is a Downstream Process Development job?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What are typical daily responsibilities for someone in Downstream Process Development?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are popular job titles related to Downstream Process Development jobs in Boston, MA? For Downstream Process Development jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Downstream Process Development jobs in Boston, MA look for? The top searched job categories for Downstream Process Development jobs in Boston, MA are:
Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Boston, MA as of May 2026, with employment types broken down into 3% Locum Tenens, 3% As Needed, 36% Full Time, 52% Part Time, 3% Temporary, and 3% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $76,114 per year, or $36.6 per hour.
Engineer - E2E Pivotal Drug Substance Development (JP13969)

Engineer - E2E Pivotal Drug Substance Development (JP13969)

3 Key Consulting

Cambridge, MA

$36 - $41/hr

Other

Posted 28 days ago

Job description

Job Title: Engineer - E2E Pivotal Drug Substance Development (JP13969)
Location: Cambridge, CA. 02138
Employment Type: Contract
Business Unit: AMA Pilot Plant
Duration: 1+ years (with likely extensions and/or conversion to permanent)
Rate: $36 - $41/ hour
Posting Date: 04/19/25
Notes: Only qualified LOCAL candidates need apply. Must have lab or relevant industry experience and at least one year working on similar projects*
3 Key Consulting is hiring an Engineer for a consulting engagement with our direct client, a leading global biopharmaceutical company.
Job Description:
*** The candidate must have lab or relevant industry experience and at least one year working on similar projects
*** Ideal Candidate: B.S. graduate with some work experience. Around 1+ YOE is ideal.
Nice to have: Maintenance background; hands-on experience with equipment support and troubleshooting.
The Pivotal Drug Substance Technologies organization at our client is seeking a skilled Engineer to join their team. This lab-based position that involves developing, characterizing, and supporting clinical drug substance manufacturing processes for late-stage programs in their product portfolio. The Pivotal Drug Substance Technologies organization at our client develops, characterizes and supports clinical drug substance manufacturing processes for all late-stage programs in their product portfolio.
This lab-based position is located at our Cambridge, MA site. The successful candidate will be responsible for the development, characterization and scale-up of upstream and downstream processes to enable clinical advancement of programs. The candidate will also be responsible for equipment maintenance and reliability. This role will include project-based work managed by the candidate.
This role is in an integrated bioprocess development group in which cell culture and purification scientists work together to advance client's rich, exciting and dynamic pipeline. With their approach, the position provides the unique opportunity to work on multiple modalities including antibodies, BiTEs, and bispecifics.
The successful candidate will design and execute experiments spanning the end-to-end drug substance process, including both cell culture and purification operations. The candidate will apply established platform approaches and utilize problem-solving skills to rapidly solve day-to-day experimental challenges. Additionally, the candidate will utilize out-of-the-box thinking to contribute to laboratory operations, technology development, and process automation. Finally, the candidate will also expand and develop skills in both cell culture and purification, thereby further contributing to the integrated group.
Top Must Have Skills:
  • Organized project work
  • Proactive troubleshooting
  • Collaborative project experience
  • Asset management experience

Day to Day Responsibilities:
  • Ensure preventative maintenance is performed on equipment
  • Coordinate and organize project work
  • Support continuous improvement projects
  • Cell Culture and Bioreactor Management: Culturing mammalian cells, maintaining bench-scale bioreactors, and sampling bioreactors.
  • Process Analytical Technologies (PAT): Utilizing PAT for process monitoring, optimization, and control.
  • Data Analysis: Compiling and analyzing experimental data to support process development and optimization.
  • Equipment Maintenance: Ensuring equipment reliability and performing routine maintenance.
  • Project Management: Managing project-based work and collaborating with cross-functional teams.
  • Experiment Design and Execution: Designing and executing experiments spanning cell culture and purification operations, applying established platform approaches, and solving day-to-day experimental challenges.
  • Innovation and Technology Development: Contributing to laboratory operations, technology development, and process automation through innovative thinking.

Basic Qualifications:
Master degree OR Bachelor degree and 2 years of experience OR Associate degree and 6 years of experience OR High school diploma / GED and 8 years of experience
Preferred Qualifications:
  • Master's degree in Chemical Engineering, Biochemical Engineering, Life Sciences, or other relevant sciences with a demonstrated record of excellence.
  • Ability to identify, develop and implement solutions to practical problems through application of fundamental scientific and engineering principles, preferably in a process development environment.
  • Prior experience with high throughput systems (such as the AMBR) or PAT.
  • Prior experience with project management.
  • Motivated self-starter with excellent interpersonal and organizational skills. Team player with the ability to successfully work within a diverse team in a dynamic, cross-functional environment.
  • Familiarity with design of experiments and statistical analysis of data desirable.
  • Prior experience with data analytical tools (Excel, Spotfire, Python etc.)

Red Flags:
  • Low GPA. Non-scientific major / experience.
  • Candidates must be willing to grow and develop.
  • Job hopping.

Interview process:
MS teams screen followed by in-person panel interviews.
We invite qualified candidates to sendyour resume toresumes@3keyconsulting.com. Ifyou decide that you're not interested in pursuing this particular position, please feel free to take a look at the other positions on our websitewww.3keyconsulting.com/careers. You are also welcome to sharethis opportunity withanyone you think might be interested in applying for this role.

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