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Downstream Process Development Jobs in Boston, MA

JobRx, Inc.

Global Head of Drug Substance

Cambridge, MA · On-site

$230 - $360/hr

Broad experience across the full process development cycle, including synthetic route scouting, salt selection, upstream and downstream process optimization, and evaluation of process alternatives ...

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Downstream Process Development information

See Boston, MA salary details

$20

$36

$53

How much do downstream process development jobs pay per hour?

As of Aug 19, 2026, the average hourly pay for downstream process development in Boston, MA is $36.59, according to ZipRecruiter salary data. Most workers in this role earn between $30.05 and $44.90 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What job categories do people searching Downstream Process Development jobs in Boston, MA look for?

The top searched job categories for Downstream Process Development jobs in Boston, MA are:

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 82% Full Time, 14% Part Time, and 3% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $76,114 per year, or $36.6 per hour.

Biologics Drug Product Process Development Scientist (Contract)

Vertex Pharmaceuticals Incorporated

Boston, MA • On-site

$55/hr

Full-time

Re-posted 28 days ago

Vertex Pharmaceuticals rating

6.5

Company rating: 6.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

78th of 86 rated pharmaceutical

Job description


Vertex is seeking a Scientist to join our Process Development team to support the development and manufacturing of biologics drug products for our growing pipeline. The Vertex Process Development team offers a dynamic, fast-paced, and highly collaborative environment with a tremendous impact on our programs and for our patients. Our team focuses on bringing together the best process design, scale-up and cutting-edge manufacturing technologies to enable the successful implementation of Biologics, Cell and Genetic therapeutics.
The successful candidate will support the development and manufacturing of biologics drug products. The responsibilities include formulation development, primary container development, fill-finish process development, and technology transfer of manufacturing processes to CDMOs to support our clinical pipeline.
Key Duties and Responsibilities:
  • Support drug product development, process transfer, and scale-up activities.
  • Assess molecule developability and determine formulation screening strategies for biologics, ADCs and other biologics modalities.
  • Develop robust fill-finish manufacturing processes for liquid and lyophilized drug products in vials, pre-filled syringes and other novel primary packaging formats.
  • Establish preclinical and clinical dose preparation and administration protocols for drug products.
  • Analyze and trend stability data to understand product degradation pathways and inform development strategy.
  • Author and/or review technical protocols, reports, and documentaiton to support development activities and technology transfer.
  • Perform wet-lab activities as needed to support program objectives.
  • Located on-site at our Boston Seaport location.

Required Education:
  • Master's or PhD in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, or a related discipline, with 3-5 years of industry experience, or equivalent years of education and experience; a PhD with 1-2 years of industry experience, or equivalent years of education and experience.
  • Direct industry experience in biologics drug product development.

Required Experience and Skills:
  • Hands-on experience in formulation development for recombinant proteins, including antibodies, ADCs, and fusion proteins.
  • Experience developing stable, high-concentration liquid formulations and dosage forms for biologics.
  • Experience developing aseptic fill-finish manufacturing processes for biologic drug products in vial, pre-filled syringe, and cartridge formats.
  • Experience using analytical techniques to characterize physical and chemical properties of biologics.
  • Knowledge of cGMPs and regulatory guidelines for biologics.
  • Familiarity with biologics upstream and downstream processes.
  • Strong data analysis, technical writing, and scientific communication skills

Contract Length: 6 months with the chance to extend
Pay Range
$55/hr. - $60/hr.
Shift/Hours
Monday - Friday
Requisition Disclaimer
This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals ("Vertex"). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements
By applying for this position, you agree to the Atrium Terms and Conditions and you direct Atrium to share your application materials, which may include your CV/Resume, email address or phone number, with Vertex. For more information on how Vertex handles your personal data related to your job application, please see Vertex's Careers Privacy Notice. Agreeing to the Atrium Terms and Conditions, includes permission to use the email address and mobile phone number you provide during the application process or throughout the duration of your prospective or actual employment to notify you of job openings, profiles, articles, news, and other employment-related information, as well as to notify you of special promotions or additional products and services offered by us or our affiliates and partners
(collectively, "Atrium Alerts"). Atrium Alerts may be sent by email, phone, or text message. Your personal information will be safely stored within the Atrium & Vertex databases. Atrium does not sell your personal information to third parties. Text message and data rates may apply. To OPT OUT of text messaging or to modify your communication preferences for Atrium Alerts at any time, please contact Atrium at privacyadministrator@atriumstaff.com.
If you do not agree with the Atrium Terms and Conditions, you can still complete your application for this position by emailing your resume to our team at tempstaffing@vrtx.com. Please include the job title in the subject of your email.
No C2C or Third-Party Vendors

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