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Downstream Process Development Jobs in Boston, MA

Amgen

Process Development Associate

Cambridge, MA · On-site

Process Development Associate What you will do Let's do this. Let's change the world. In this vital ... and downstream manufacturing processes supporting Ph II/III clinical trials to marketing ...

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

Managed Staffing

Purification Scientist

Boston, MA · On-site

$44 - $46/hr

Monday-Friday | 8:00 AM-5:00 PM (40 hrs/week Position Summary Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will ...

AT Process Technologies

Process Chemist

Waltham, MA · On-site

$130K - $200K/yr

Summary We are seeking a process development chemist to own and execute the research, development ... Develop and optimize core synthesis and downstream processing, evaluating competing technical ...

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All JobsDownstream Process Development JobsDownstream Process Development Jobs in Boston, MA

Downstream Process Development information

See Boston, MA salary details

$20

$36

$53

How much do downstream process development jobs pay per hour?

As of Sep 10, 2026, the average hourly pay for downstream process development in Boston, MA is $36.59, according to ZipRecruiter salary data. Most workers in this role earn between $30.05 and $44.90 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Boston, MA as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 85% Full Time, 11% Part Time, and 2% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $76,114 per year, or $36.6 per hour.

Director, Process Development

Lexington, MA • On-site, Remote

Keros Therapeutics
Biotechnology Research and Development • 1 - 10 employees
Learn more about Keros Therapeuticsexternal

$200K - $230K/yr

Full-time

Re-posted 19 days ago

Job description

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.
Job Summary
This role is responsible for providing overall management of the Process Development group with a focus on biologics. The position will lead a group of Process Scientists and Engineers in the development and tech transfer of processes for different stages of multiple biologics programs. The candidate will also coordinate with multiple internal teams to support successful, early program transition from Research to Development, internal process development studies, and production of material for toxicology studies.
Primary Responsibilities
  • Serves as Process Development department head overseeing planning, execution, and project delivery in a fast-paced environment
  • Manage, mentor and facilitate the development of the staff in Upstream and Downstream Process Development
  • Strong working knowledge of upstream and downstream process technologies
  • Provide hands-on expertise and strategic guidance for bench-scale to pilot-scale bioreactor operations, ensuring scalable and robust processes
  • Design and execute studies to evaluate critical culture conditions (e.g., pH, DO, feeding profiles, shear stress) to optimize growth, viability, and product quality
  • Drive innovation and development of process technologies that can result in significant increases in efficiency and purity
  • Partner closely with downstream teams to ensure seamless interface between cell culture harvest and purification steps
  • Operate within a cross-functional project team environment and coordinate efforts with all relevant internal functional areas including Quality, Manufacturing, Analytical Development, Program Management, Formulation Development, Research, non-Clinical (Tox)
  • Lead group in successful operations for supply of material for use by other groups (Bioanalytical, Tox, etc) and process development studies
  • Have direct experience with establishing production processes for biologics in cGMP manufacturing settings
  • Determine areas for gaining efficiency, coordinates with individual groups and ensure harmonized implementation of best practices
  • Support the development and maintenance of budgets, manpower and capital requirements for process development group
  • Actively provides career path and development for team members
  • Execution of process development studies, review of the data, and documentation of all activities according to the appropriate laboratory procedure
  • Experience throughout the biopharmaceutical product life-cycle including process characterization studies, in-process control strategy and process validation is preferred but not required

Preferred Skills
  • Management experience must include managing a team of at least 5
  • Experience reviewing and/or authoring CMC sections for regulatory submissions
  • Demonstrated ability to work cross functionally to achieve goals
  • Knowledge of upstream and downstream process development for biologics
  • Proven track record of running, programming, and scaling bench-to-pilot scale bioreactor systems
  • Ability to multi-task and handle successful execution of multiple parallel programs
  • Knowledge of cGMP and manufacturing operations
  • Knowledge of tech transfer
  • Knowledge of good lab practices including hands-on implementation
  • Knowledge of regulatory guidelines, particularly those for IND filing

Education Requirements
  • Minimum requirement is a Bachelor of Science degree in a scientific discipline with a minimum of 10 years of technical management experience; a Master's degree with 8 years or a Doctorate degree in a scientific or biochemical engineering area (or equivalent. Additionally, at least 5 years' experience serving in a relevant managerial capacity required

This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors.
Potential base pay range
$200,000-$230,000 USD
Our Diversity, Equity & Inclusion Mission Statement:Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.
Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.
Recruitment & Staffing Agencies:Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.

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