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Downstream Process Development Jobs in Apex, NC (NOW HIRING)

Valspec

Process Validation Engineer

Raleigh, NC · On-site

$70 - $80/hr

Process Engineer -- Upstream / Downstream / Clean Utilities (Consultant) -- Contract Engagement ... Join a team where your contributions matter, your development is prioritized, and your success is ...

DivIHN

Lab Technician I

NC · On-site

$18.25 - $24.50/hr

... Downstream Support Activities - 20% • Clean and autoclave glassware, • Sanitize automated ... Process Development Associate Director/Director

Cree

Process Sustaining Engineer

Durham, NC

$88K - $108K/yr

Interacting with product design and development personnel to ensure that processes and designs are ... Collaborating with downstream departments, facilities, logistics and software teams to resolve ...

New

Valspec

Process Engineer Consultant

Raleigh, NC

Support commissioning, startup, and qualification activities for upstream and/or downstream ... Join a team where your contributions matter, your development is prioritized, and your success is ...

Vadum Inc

DSP Engineer

Raleigh, NC · On-site

$125K - $180K/yr

... downstream processor/memory resource utilization. * Participate in all phases of development life cycle (requirements, block diagrams, integration, evaluation, and test activities). * Work in a ...

Vadum Inc.

DSP Engineer with Security Clearance

Raleigh, NC · On-site

$127K - $149K/yr

... downstream processor/memory resource utilization. • Participate in all phases of development life cycle (requirements, block diagrams, integration, evaluation, and test activities). • Work in a ...

Vadum Inc

DSP Engineer

Raleigh, NC · On-site

$125K - $180K/yr

... and downstream processor/memory resource utilization. Participate in all phases of development life cycle (requirements, block diagrams, integration, evaluation, and test activities). Work in a ...

Vadum, Inc.

DSP Engineer

Raleigh, NC · On-site

$125K - $180K/yr

... downstream processor/memory resource utilization. • Participate in all phases of development life cycle (requirements, block diagrams, integration, evaluation, and test activities). • Work in a ...

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Downstream Process Development information

See Apex, NC salary details

$14

$25

$37

How much do downstream process development jobs pay per hour?

As of Aug 19, 2026, the average hourly pay for downstream process development in Apex, NC is $25.66, according to ZipRecruiter salary data. Most workers in this role earn between $21.06 and $31.49 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Apex, NC as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 18% Part Time, and 4% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $53,383 per year, or $25.7 per hour.

Process Engineer II

Asklepios BioPharmaceutical, Inc.

Durham, NC • On-site

Full-time

Posted 15 days ago

Job description

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson's disease, and Pompe disease. AskBio's gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:
  • Advance innovative science by pushing boundaries.
  • Bring transformative therapeutics to patients in need.
  • Provide an environment for employees to reach their fullest potential.

Our values:
  • Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
  • Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
  • Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
  • Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
  • Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.

Position Summary
AskBio is seeking a Process Engineer II to join our MSAT Process Engineering team and support current and future commercialization efforts. This position supports scale-up, technology transfer of AskBio's portfolio of gene therapy products into cGMP manufacturing for clinical production, process validation and commercial launch. The incumbent will onboard clinical programs into the MSAT laboratory, perform scale-up runs, and transfer programs to AskBio's contract manufacturing facility. Additionally, this position will be responsible for performing Phase III clinical enabling activities including scale-down model development and qualification, process characterization, and process control strategy definition to enable process performance qualification (PPQ) readiness for both drug substance and drug product manufacturing campaigns. This position is highly collaborative and will require internal and external team interactions to ensure successful process scale-up, technology transfers, and cGMP manufacturing operations to ensure continuity of supply while adhering to global regulations and standards.
This role is based on-site at our RTP (Research Triangle Park) Headquarters in NC and reports to an Associate Director, MSAT.
Job Responsibilities
  • Collaborate with cross-functional teams to transfer small-scale gene therapy processes from Process Development into the MSAT laboratory and subsequently perform scale-up and transfer to the cGMP manufacturing scale
  • Perform process characterization experiments to generate robustness data and define the process control strategy for PPQ manufacturing campaigns. Contribute to process characterization experimental design and data analysis
  • Develop and qualify small-scale models that are predictive of the cGMP manufacturing scale
  • Author technical protocols and reports to support experimental work and maintain clear, organized electronic laboratory notebooks
  • Provide effective communication of experimental results in technical presentations with internal stakeholders
  • Support investigations by contributing technical expertise to root-cause analyses and using a data-driven approaches for driving issue resolution
  • Ensure the laboratory is clean, organized and maintained in an efficient working order, includes scheduling routine preventative maintenance/calibration of instruments/equipment, securing supplies and materials for experiments, and proper scheduling of laboratory work

Minimum Requirements
  • Bachelor's Degree in a scientific discipline with 2+ years of Biopharmaceutical Experience; OR Master's Degree in a scientific discipline; OR High School Diploma with 6+ years of biopharmaceutical Experience
  • Hands-on upstream or downstream biomanufacturing laboratory experience
  • Excellent written and verbal communication skills, with experience interacting with a range of internal stakeholder groups
  • Proficiency in using Microsoft Office Suite (Word, Excel, PowerPoint)
  • Highly motivated, organized, and disciplined, with a strong desire to contribute as part of a best-in-class, collaborative tech transfer team
  • Adaptable and eager to learn, thriving in a fast-paced, highly interactive environment
  • Genuinely interested in building proficiency in upstream and downstream biomanufacturing operations, including process scale-up, technology transfer, process characterization, and process control strategy development
  • Continuous improvement-oriented, seeking opportunities to optimize process operations and performance through proactive problem solving
  • Open to domestic and international travel up to approximately 10%, as needed

Preferred Education, Experience and Skills
  • Prior downstream experience
  • Experience with viral vectors
  • Experience supporting cGMP manufacturing operations
  • Knowledge of the Design of Experiment (DOE) methodology with an ability to design, execute, and analyze experiments with oversight. JMP Statistical Software proficiency is highly preferred

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job-related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email at careers@askbio.com.
Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.

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