ZipRecruiter

Log In

1

Downstream Process Development Jobs in Apex, NC (NOW HIRING)

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

Must have demonstrated biologics expertise in upstream or downstream processing and operations * Must have experience in collaborating with process development, quality, supply chain, engineering and ...

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC

Must have demonstrated biologics expertise in upstream or downstream processing and operations * Must have experience in collaborating with process development, quality, supply chain, engineering and ...

AskBio

Process Engineer II

Durham, NC · On-site

... and downstream biomanufacturing operations, including process scale-up, technology transfer, process characterization, and process control strategy development * Continuous improvement-oriented ...

AskBio

Process Engineer II

Durham, NC · On-site

... upstream and downstream biomanufacturing operations, including process scaleup, technology transfer, process characterization, and process control strategy development * Continuous ...

previous pagenext page

Showing results 21-40

All JobsDownstream Process Development JobsDownstream Process Development Jobs in Apex, NC

Downstream Process Development information

See Apex, NC salary details

$14

$25

$37

How much do downstream process development jobs pay per hour?

As of Aug 19, 2026, the average hourly pay for downstream process development in Apex, NC is $25.66, according to ZipRecruiter salary data. Most workers in this role earn between $21.06 and $31.49 per hour, depending on experience, location, and employer.

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in Apex, NC as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 18% Part Time, and 4% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $53,383 per year, or $25.7 per hour.

Senior Director, MS&T

KBI Biopharma, Inc.

Durham, NC • On-site

Full-time

Posted 20 days ago

KBI Biopharma rating

6.5

Company rating: 6.5 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

JOB SUMMARY
The Manufacturing Science and Technology (MS&T) Director or Senior Director is responsible for establishing and directing the execution, resources, business processes and best practices for tech transfer, process validation, and support laboratory activities for the MS&T department at the Durham Patriot Park Manufacturing site. The Director or Senior Director will manage a multi-disciplinary team of Engineers and Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities, Engineering, and Manufacturing to ensure projects are executed efficiently and in a timely manner. The Director or Senior Director should demonstrate proven technical expertise in upstream or downstream biologics and have strong knowledge of industry best practices.
The scope of this role includes:
  • Drive new commercial product introduction and process validation from Stage 2 PPQ through Stage 3 CPV Process Validation and Pre-Approval Inspection (PAI)
  • Drive new clinical product introduction to ensure successful tech transfer through collaboration with Process Development
  • Establish and maintain the procedures, business processes and tools/systems for tech transfer to ensure that the business
  • Drive standards and industry best practices to ensure organizational efforts are scalable and sustainable across sites
  • Establish plans and strategies to ensure successful cGMP production by actively collaborating with manufacturing operations, quality and supply chain
  • Drive activities of department resources to facilitate revenue growth and risk mitigation for manufacturing organization.
  • Recruit and retain talent within organization.
  • Represent the department during audits, client meetings and multi-disciplinary meetings with boards of health and upper management.
  • Lead multi-disciplinary projects and strategic oversight for robust manufacturing operations, facility designs, new technology implementation, production revenue growth, cost of goods optimization and streamlined practices.
  • Perform a wide range of managerial duties pertaining to employees including hiring, on-the-job training, career development, appraising performance, promotion and disciplinary effort. Identify opportunities and provide the means for employees to pursue career growth.

JOB RESPONSIBILITIES
The candidate must apply sound judgment and effective decision making to drive the strategic objectives of the department and influence the broader business as a whole. In addition, the candidate is required to apply sound technical and management principles in order to drive tech transfer, process validation, process engineering and execution of support laboratory efforts and facilitate project execution and department performance within defined timelines. The ability to manage multiple projects and resources is required.
The candidate should have the ability to drive direction and have excellent communication skills in order to influence company objectives.
  • Leads multi-disciplinary cross-functional projects
  • Provides technical guidance to tech transfer, process validation, process engineering and laboratory efforts
  • Oversees and maintains the procedures, business processes and tools for downstream tech transfer.
  • Represents department in various technical and projects team meetings with client, board of health and upper management.

MINIMUM REQUIREMENTS
  • BS in Science or Engineering with minimum of 18 years industry experience, Masters with 16 years industry experience or PhD with 14 years industry experience.
  • Must have demonstrated biologics expertise in upstream or downstream processing and operations
  • Must have experience in collaborating with process development, quality, supply chain, engineering and manufacturing.
  • Demonstrated expertise in technical transfer, process validation, process engineering and optimization/scale up of biological processes is required
  • Demonstrated knowledge of industry best practices, boards of health guidelines, cGMP compliance and engineering standards is required
  • Experience with cGMP production operations is required
  • Experience working in a cGMP manufacturing environment is a plus

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.
I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.
I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

What KBI Biopharma employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom

Apply