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How much do downstream manufacturing lead jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for downstream manufacturing lead in the United States is $26.85, according to ZipRecruiter salary data. Most workers in this role earn between $20.91 and $29.81 per hour, depending on experience, location, and employer.

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Infographic showing various Downstream Manufacturing Lead job openings in the United States as of September 2026, with employment types broken down into 88% Full Time, 10% Part Time, and 2% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $55,858 per year, or $26.9 per hour.

Downstream Manufacturing Associate III - 3rd Shift

Milford, MA • On-site

JMD Technologies Inc.
See more jobs at JMD Technologies Inc.external

$35 - $44/hr

Other

Posted 9 days ago

Job description

Title: Downstream Manufacturing Associate III

Location: Milford, MA (Onsite, 3rd Shift)

Employment Type: Contract, 6+ Months

Status: Accepting Candidates

About the Role

Support GMP downstream manufacturing operations for clinical, development, validation, and commercial-scale activities, serving as a technical resource for purification processes, equipment operation, troubleshooting, and team training.

Key Responsibilities

  • Execute downstream manufacturing operations involving tangential flow filtration (TFF), chromatography, monoclonal antibody (mAb) purification, and disposable technologies.
  • Operate and troubleshoot manufacturing equipment and systems, including ÄKTA systems, XDUO buffer systems, process tanks, chromatography skids and columns, and related production equipment.
  • Monitor and document batch parameters, complete GMP/GDP documentation, perform calculations, and support deviations, investigations, event management, and batch-record revisions.
  • Train and oversee newer operators, serve as a subject matter expert, and support cross-functional teams and manufacturing stakeholders.
  • Lead or contribute to continuous improvement initiatives and process improvements while maintaining cleanroom, safety, and production requirements.

Qualifications

  • High school diploma with 6+ years of related experience, an associate degree in Life Sciences/Engineering with relevant experience, or a bachelor's degree with 4+ years of related experience; biotech certification preferred.
  • Demonstrated experience in cGMP downstream manufacturing, particularly TFF, chromatography, and mAb purification.
  • Experience operating and troubleshooting laboratory and pharmaceutical production equipment and applying structured problem-solving/root-cause analysis.
  • Strong technical documentation, communication, computer, and Microsoft Word/Excel skills, with the ability to author procedures and complete GMP records accurately.
  • Ability to work effectively in a cleanroom environment, follow hygiene and PPE requirements, and work the required overnight schedule, including weekends, holidays, and overtime as needed.

Compensation:

  • $35–$44/hr + 20% shift differential.
  • Final compensation within the posted range will depend on qualifications, experience, and interview results.


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