Director Hydra Jobs (NOW HIRING)

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Job Summary:
Lead the AI/ML innovation & deployment for oncology discovery. This role will architect and operationalize stateoftheart machine learning-including deep learning, foundation models, and LLMpowered applications-to accelerate target identification & validation, protein and antibody design, and multimodal data integration across our discovery pipeline. Partnering closely with biology, chemistry, translational sciences and data hub, you'll transform heterogeneous molecular and phenotypic data into actionable hypotheses, design in silico-to-in vitro loops, and deliver decisionquality insights that shape our discovery roadmap. This role also steers platformization efforts for in silico design & advancement of antibody, XDC development and nextgeneration data products that scale across programs.
Job Responsibilities:

• Innovate and execute the AI/ML strategy for discovery. Build a portfolio of models for target ID/validation, structure and sequencebased protein design (e.g., antibodies, conjugates), modeofaction inference, and biomarker discovery. Establish retrievalaugmented and agentic LLM workflows for knowledge mining (literature, patents, internal reports) and protocol/screen design assistance.

• Develop nextgen data integration platforms. Integrate bulk & singlecell transcriptomics, WES/WGS, proteomics, CRISPR screen data, imaging, functional readouts, and realworld knowledge graphs into unified modelready datasets. Drive ontology/harmonization, feature stores, and model registries for reproducibility and added value extraction.

• Advance computational protein & antibody design. Leverage transformerbased sequence models, diffusion/graph methods, and physicsinformed constraints for binder optimization, specificity, and developability; operationalize activelearning loops with design-make-test cycles. Lead antibody-siRNA conjugate design heuristics and predictive models for delivery and efficacy.

• Design & oversee experiments (dry & wet). Plan benchmarking and prospective validation; pair ML predictions with targeted assays and orthogonal analytics. Build feedback loops to refine models with experimental results and postmarket learnings.

• Crossfunctional impact & leadership. Partner with Biology/Chemistry/Translational/Clinical Biomarkers to convert insights into program decisions. Represent computational strategy in steering committees and external partnerships; publish/present at top venues. Mentor and grow a highperforming team (data scientists, ML engineers, bioinformaticians) with strong engineering and scientific rigor.

• Deliver robust, scalable ML systems. Own MLOps (data/feature pipelines, training/evaluation services, CI/CD, monitoring) on cloud (e.g., AWS) with containerization and orchestration (Docker/Kubernetes). Institute model governance: experiment tracking, versioning, bias/variance reporting, and validation SOPs.

• Foundational bioinformatics. Bestpractice omics analysis (RNA/DNAseq, singlecell, proteomics), QC, and statistical analysis. Ensure data integrity, FAIR practices, to advance oncology drug discovery programs.

Basic Requirements:

• PhD in Computer Science, Computational Biology, Bioinformatics, Statistics, Applied Math, or related STEM field.

• 5+ years of postdoctoral/industry experience delivering ML solutions in biotech/pharma or adjacent domains.

Preferred Requirements:

• Experience in leading teams and crossfunctional initiatives is preferred.

• Demonstrated impact applying deep learning to biological problems (e.g., transformers for protein/antibody sequence, structure prediction/refinement, graph learning, diffusion models, transfer learning, multimodal integration).

• Deep handson expertise with PyTorch (preferred) and/or JAX/TensorFlow; experience with Hugging Face (Transformers, Diffusers) and foundationmodel finetuning (LoRA/PEFT, adapters, RAG).

• Track record building LLM applications (prompt engineering, tool use/agents, vector databases, retrieval pipelines) for knowledge extraction, hypothesis generation, and protocol design in drug discovery.

• Strong software engineering skills: Python, ML tooling (PyTorch Lightning, Hydra, Weights & Biases/MLflow), Git/GitHub, code review, testing & productionizing models with Docker/Kubernetes, APIs, and AWS services (e.g., S3, Batch/EKS, Lambda, Step Functions, SageMaker or equivalent).

• Solid grounding in statistics/causal inference/experimental design; experience closing model-experiment loops.

• Evidence of scientific leadership: highquality publications, patents, opensource contributions, or conference talks.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

$193,500 - $283,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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