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Director Clinical Research Operations Jobs (NOW HIRING)

Temple University

$120K/yr

The Clinical Research Nurse Manager in the Lewis Katz School of Medicine's Department of Research Administration will assist the Senior Director, Clinical Research Operations, the Regulatory team and ...

UNC HEALTH

Director Clinical Research

Raleigh, NC · On-site

Provides strategic, operational, regulatory, financial, and program leadership for the Heart & Vascular clinical research portfolio. Directs program-level planning, workforce development, and ...

Phsorg

Research Operations Managers/Supervisors (as applicable); Clinical Research Coordinators and ... Direct research administration, quality assurance, compliance monitoring, education, and continuous ...

Insight

Associate Director Research Operations

Flint, MI · On-site

$140 - $190/hr

Flint, MI Job Id: 2496 # of Openings: 1 Insight Health System Clinical Research Associate Director, Research Operations Title: Associate Director - Research Operations Location: Michigan Reports To:

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How much do director clinical research operations jobs pay per year?

As of Sep 7, 2026, the average yearly pay for director clinical research operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What does a director clinical research operations do?

A Director of Clinical Research Operations oversees the planning, execution, and management of clinical research studies within an organization. They are responsible for ensuring compliance with regulatory requirements, managing budgets and timelines, and leading teams of clinical research professionals. Their role includes collaborating with cross-functional departments, optimizing operational efficiency, and maintaining high standards of data quality and patient safety throughout the clinical trial process.

What are the key skills and qualifications needed to thrive as a director clinical research operations?

To thrive as a Director of Clinical Research Operations, you need extensive knowledge of clinical trial management, regulatory compliance, and a background in life sciences or a related field, often supported by an advanced degree and significant industry experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications such as CCRA or CCRP are typically required. Strong leadership, strategic planning, and interpersonal skills distinguish top performers in this role. These skills ensure effective oversight of complex research projects, regulatory adherence, and successful collaboration across multidisciplinary teams.

What are some common challenges faced by a director clinical research operations, and how can they be effectively managed?

A Director of Clinical Research Operations often faces challenges such as balancing regulatory compliance with operational efficiency, managing cross-functional teams, and ensuring timely study delivery within budget constraints. To address these, it’s important to establish robust communication channels, develop standardized processes, and foster a collaborative environment with clinical staff, regulatory affairs, and sponsors. Staying updated on evolving regulations and investing in team training also help in proactively managing these complexities, ensuring both compliance and successful study outcomes.

What is the difference between Director Clinical Research Operations vs Clinical Research Manager?

AspectDirector Clinical Research OperationsClinical Research Manager
ResponsibilitiesOversees multiple clinical projects, strategic planning, and department leadershipManages daily clinical trial activities, site coordination, and team supervision
Required CredentialsBachelor's/Master's in life sciences, extensive experience, often certificationsBachelor's degree, relevant experience, certifications preferred
Work EnvironmentSenior leadership in pharmaceutical or biotech companiesOperational teams within clinical research sites or CROs
Industry UsageUsed in large organizations for strategic rolesCommon in mid-sized to large research organizations

The main difference is that the Director Clinical Research Operations focuses on strategic oversight and leadership of clinical research activities, while the Clinical Research Manager handles day-to-day trial management and site coordination. Both roles require relevant experience and certifications, but the director position involves broader organizational responsibilities.

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Director Clinical Research Operations jobs near you
Infographic showing various Director Clinical Research Operations job openings in the United States as of August 2026, with employment types broken down into 84% Full Time, 13% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Clinical Research Operations Manager

NextGen Research Group

Miami, FL • On-site

Full-time

Re-posted 25 days ago

Key responsibilities

  • Oversee the daily administrative and operational functions of the clinical research site.

  • Support study startup activities, including regulatory document collection, site qualification, and sponsor communications.

  • Coordinate clinical research studies by screening, enrolling, scheduling participants, and maintaining study documentation.

Job description

Description:

NextGen Research Group is seeking a bilingual (English/Spanish), highly organized, proactive, and experienced Clinical Research Operations Manager to oversee the daily operations of our growing clinical research site. This leadership role is responsible for ensuring the efficient management of office operations, supporting business development and study startup activities, maintaining regulatory compliance, and providing clinical research coordination support when needed. The ideal candidate is an experienced clinical researcher who enjoys building relationships with sponsors and CROs and can balance operational oversight with hands-on study coordination.


Responsibilities include, but are not limited to:

Research Operations

  • Oversee the day-to-day administrative and operational functions of the clinical research site.
  • Develop and maintain efficient workflows to support research operations.
  • Ensure compliance with FDA, GCP, HIPAA, IRB, and sponsor requirements.
  • Assist with the implementation and maintenance of Standard Operating Procedures (SOPs).
  • Monitor site performance and identify opportunities for operational improvements.
  • Coordinate office resources, vendors, supplies, and equipment to support research activities.


Study Startup & Business Development

  • Complete feasibility questionnaires and sponsor surveys.
  • Assist with study feasibility assessments and site selection activities.
  • Prepare and submit study applications to sponsors and CROs.
  • Support study startup activities, including regulatory document collection and essential document preparation.
  • Assist with site qualification, initiation, and monitoring visits.
  • Maintain positive relationships with sponsors, CROs, investigators, and research partners.
  • Attend local and national clinical research conferences, investigator meetings, and industry events to represent NextGen Research Group and cultivate relationships with sponsors, CROs, and research partners.


Clinical Research Coordination

  • Coordinate assigned clinical research studies as needed.
  • Screen, recruit, consent, enroll, and retain study participants.
  • Schedule participant visits and ensure protocol-required procedures are completed.
  • Maintain accurate source documentation, electronic case report forms (eCRFs), and regulatory files.
  • Ensure protocol compliance and timely resolution of data queries.
  • Conduct participant follow-up and maintain excellent participant engagement.
  • Serve as a liaison between investigators, sponsors, CROs, and study participants.


Leadership & Administrative Support

  • Assist with training and mentoring research staff.
  • Support investigators and leadership with operational planning and project management.
  • Track study milestones, enrollment goals, and startup timelines.
  • Participate in quality assurance activities and prepare for sponsor audits and regulatory inspections.
  • Maintain confidentiality of participant and study information.


Perform other duties as assigned.

Requirements:

Qualifications

  • Bilingual (English/Spanish) required.
  • Bachelor's degree preferred; equivalent clinical research experience will be considered.
  • Minimum of 2 years of clinical research experience, including experience coordinating clinical trials.
  • Experience with study startup activities, regulatory submissions, and sponsor/CRO communications preferred.
  • Thorough understanding of ICH-GCP, FDA regulations, HIPAA, and IRB requirements.
  • Experience maintaining regulatory documentation and study essential documents.
  • Strong organizational, project management, and problem-solving skills.
  • Excellent written and verbal communication skills.
  • Strong interpersonal skills with the ability to build relationships with sponsors, CROs, investigators, and participants.
  • Ability to manage multiple projects and priorities simultaneously while meeting deadlines.
  • Proficiency with Microsoft Office Suite and clinical research software (CTMS, eSource, eRegulatory, EDC systems preferred).
  • Ability to travel occasionally for industry conferences and sponsor meetings (~10%).
  • Must be able to pass a drug test and background screening. You may visit the Florida

Care Provider Background Screening Clearinghouse for more information.

We are a Drug-Free Workplace and are committed to providing equal employment opportunities to all applicants and employees without regard to age, disability, race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, national origin, veteran or military status, genetic information, or any other protected status under applicable federal, state, or local law.