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Director Clinical Operations Jobs in Spring, TX (NOW HIRING)

Immatics NV

Director, Clinical Operations Lead

Houston, TX · On-site

$215K - $260K/yr

The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs. Schedule ...

Immatics NV

Director, Clinical Operations Lead

Houston, TX · On-site

$215K - $260K/yr

The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs. Schedule ...

ChenMed

Associated Center Clinical Director

Houston, TX · On-site

$238K - $341K/yr

The Associate Clinical Director will directly supervise and train primary care providers (PCPs) in ... Partnering with Center Operations Director/Market General Manager to drive continued improvement of ...

ChenMed

Associated Center Clinical Director

Houston, TX · On-site

$238K - $341K/yr

The Associate Clinical Director will directly supervise and train primary care providers (PCPs) in ... Partnering with Center Operations Director/Market General Manager to drive continued improvement of ...

ChenMed

Associated Center Clinical Director

Houston, TX · On-site

$238K - $341K/yr

The Associate Clinical Director will directly supervise and train primary care providers (PCPs) in ... Partnering with Center Operations Director/Market General Manager to drive continued improvement of ...

ChenMed

Associated Center Clinical Director

Houston, TX · On-site

$238K - $341K/yr

The Associate Clinical Director will directly supervise and train primary care providers (PCPs) in ... Partnering with Center Operations Director/Market General Manager to drive continued improvement of ...

ChenMed

Associated Center Clinical Director

Houston, TX · On-site

$238K - $341K/yr

The Associate Clinical Director will directly supervise and train primary care providers (PCPs) in ... Partnering with Center Operations Director/Market General Manager to drive continued improvement of ...

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All JobsClinical Operations JobsDirector Clinical Operations JobsDirector Clinical Operations Jobs in Spring, TX

Director Clinical Operations information

See Spring, TX salary details

$53.4K

$129.9K

$251.4K

How much do director clinical operations jobs pay per year?

As of Jul 15, 2026, the average yearly pay for director clinical operations in Spring, TX is $129,897.00, according to ZipRecruiter salary data. Most workers in this role earn between $90,800.00 and $154,400.00 per year, depending on experience, location, and employer.

What Does a Director of Clinical Operations Do?

A director of clinical operations manages the daily operations of a healthcare facility or a specific department within a clinic or hospital. As a director of clinical operations, your responsibilities include scheduling staff to ensure proper coverage of patients and overseeing the productivity of your team to meet the organization's expectations. You define policies and procedures, facilitating further training when necessary. The director of clinical operations must also assess the performance of the medical team under your supervision regularly and mainstream processes when possible. Medical device manufacturers and pharmaceutical companies often hire a director of clinical operations to oversee research, lab, and testing operations.

What are the key skills and qualifications needed to thrive as a Director of Clinical Operations, and why are they important?

To thrive as a Director of Clinical Operations, you need a robust background in clinical management, regulatory compliance, and healthcare administration, often supported by a relevant degree and substantial leadership experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like PMP or CCRA are commonly required. Exceptional leadership, strategic thinking, and communication skills help drive teams, manage stakeholders, and oversee complex projects. These skills are critical for ensuring clinical programs run efficiently, meet regulatory standards, and deliver high-quality patient outcomes.

What is the difference between Director Clinical Operations vs Clinical Project Manager?

AspectDirector Clinical OperationsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MS, PhD) and extensive industry experienceUsually holds a bachelor's or master's degree in a related field, with relevant project management certifications
Work EnvironmentOversees multiple projects and teams across departments, strategic planningManages individual clinical trials, coordinates project activities, and timelines
Employer & Industry UsageUsed in pharmaceutical, biotech, and healthcare companies for senior leadership rolesCommonly employed in clinical research organizations and pharmaceutical companies for trial management

The main difference is that the Director Clinical Operations focuses on strategic oversight and leadership across multiple clinical trials, while the Clinical Project Manager handles the day-to-day management of specific clinical studies. Both roles require strong industry knowledge, but the director position involves broader responsibilities and higher-level decision-making.

What does a Director of Clinical Operations do?

A Director of Clinical Operations is responsible for overseeing the day-to-day management and strategic direction of clinical trials and research activities within healthcare organizations or pharmaceutical companies. They ensure that clinical studies are conducted efficiently, ethically, and in compliance with regulatory requirements. This role involves supervising teams, managing budgets, developing protocols, and liaising with stakeholders to ensure successful trial outcomes. Directors of Clinical Operations play a crucial role in bringing new medical treatments to market by ensuring studies run smoothly from start to finish.

How does a Director of Clinical Operations typically collaborate with cross-functional teams to ensure successful clinical trial execution?

A Director of Clinical Operations regularly collaborates with cross-functional teams such as regulatory affairs, data management, medical affairs, and biostatistics to ensure clinical trials are executed on time, within budget, and in compliance with regulations. This role involves leading team meetings, aligning project timelines, and facilitating communication between internal stakeholders and external partners like CROs and vendors. Strong coordination skills are essential, as the Director must balance diverse priorities and resolve any operational issues that arise, ensuring all teams work toward shared objectives.
More about Director Clinical Operations jobs
What are the most commonly searched types of Clinical Operations jobs in Spring, TX? The most popular types of Clinical Operations jobs in Spring, TX are:
What job categories do people searching Director Clinical Operations jobs in Spring, TX look for? The top searched job categories for Director Clinical Operations jobs in Spring, TX are:
What cities near Spring, TX are hiring for Director Clinical Operations jobs? Cities near Spring, TX with the most Director Clinical Operations job openings:
Director Clinical Operations jobs near you
Infographic showing various Director Clinical Operations job openings in Spring, TX as of July 2026, with employment types broken down into 100% Full Time. Highlights an 94% In-person, and 6% Hybrid job distribution, with an average salary of $129,897 per year, or $62.5 per hour.

Director, Clinical Operations Lead

Immatics NV

Houston, TX • On-site

$215K - $260K/yr

Full-time

Medical, Dental, Vision, Life, Retirement

This job post has expired today. Applications are no longer accepted.

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!
Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.
Why Join Us?
  • Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
  • Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
  • Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview
We are seeking a Director, Clinical Operations Lead to support our Clinical Operations team. The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs.
Schedule: 8:00 AM - 5:00 PM; Monday to Friday
Reports to: Vice President, Clinical Operations EU
Location: Fully Remote
Salary Range: $215,000.00 - $260,000.00
Basic Qualifications:
  • Bachelor's degree
  • 10+ years of demonstrated leadership of global clinical operations in the pharmaceutical or biotechnology industry including clinical trial oversight, vendor management, and cross-functional study leadership
  • Experience in oncology, cell and/or gene therapy, or other complex biologic clinical development programs

Preferred Qualifications:
  • Master's Degree, preferably in life science, nursing, or similar
  • Demonstrated ability to drive process improvements and operational excellence initiatives
  • Ability to understand and navigate complex clinical development processes and cross-functional interdependencies
  • Strong analytical and problem-solving skills with the ability to assess operational impact across broader cross-functional environments
  • Ability to operate effectively in a fast-paced and evolving clinical development environment

In this role you will:
  • Lead global clinical trial execution and operational delivery across internal and external stakeholders
  • Provide oversight of CROs, vendors, and clinical trial partners to ensure quality, compliance, timelines, and budget objectives are achieved
  • Drive risk identification, issue escalation, and mitigation planning across assigned studies
  • Support study start up, site feasibility, enrollment, and operational execution activities
  • Partner cross-functionally with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain, and external vendors
  • Contribute to SOP development, process optimization, inspection readiness, and operational excellence initiatives
  • Mentor junior Clinical Operations team members as applicable

Qualified candidates will participate in a structured interview process, which includes:
  • An initial recruiter phone screen (conducted via video)
  • A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)
  • A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX

What do we offer?
At Immatics, we believe in investing in our team's health, safety and well-being. Here's what you can expect if you join Immatics
Comprehensive Benefits:
  • Competitive rates for Health, Dental, and Vision Insurance
  • 4 weeks of vacation granted up front each year and prorated for first and last year of employment.
  • 12 company paid holidays
  • 7 days of sick time
  • 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars
  • 100% employer-paid short- and long-Term disability coverage
  • 401(k) with immediate eligibility and company match...
  • The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
  • Partially paid parental leave for eligible employees.
  • Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity
We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.
Reasonable Accommodations
We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at RecruitingUS@immatics.com.
Work Authorization
Applicants must be authorized to work in the United States without the need for current or future sponsorship. Visa sponsorships may be available for certain roles.
Pre-Employment Requirements
Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.

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