This work will integrate cryo-electron microscopy (cryo-EM), biochemical and cell biology assays, and computational modeling to elucidate mechanisms of cell signaling and inform the development of ...
This work will integrate cryo-electron microscopy (cryo-EM), biochemical and cell biology assays, and computational modeling to elucidate mechanisms of cell signaling and inform the development of ...
Perform cryo-EM grid screening, optimization, data collection and refinement to enable high-quality structure determination. * Interact with interdisciplinary teams (including chemists, computational ...
Perform cryo-EM grid screening, optimization, data collection and refinement to enable high-quality structure determination. * Interact with interdisciplinary teams (including chemists, computational ...
Postdoctoral Research Associate - Structural Biology
Memphis, TN · On-site
$72.50K/yr
We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller ...
Postdoctoral Research Associate - Structural Biology
Memphis, TN · On-site
$72.50K/yr
We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller ...
Post-Doctoral Fellow
$49.80K - $67.60K/yr
By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...
Post-Doctoral Fellow
$49.80K - $67.60K/yr
By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...
Postdoctoral Fellow-MSH-30001-321
Manhattan, NY · On-site
$53.90K - $73.20K/yr
Gain hands-on experience with cutting-edge techniques like cryo-EM and X-ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their ...
Postdoctoral Fellow-MSH-30001-321
Manhattan, NY · On-site
$53.90K - $73.20K/yr
Gain hands-on experience with cutting-edge techniques like cryo-EM and X-ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their ...
Post-Doctoral Fellow
Aurora, CO · On-site
$49.80K - $67.60K/yr
By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...
Post-Doctoral Fellow
Aurora, CO · On-site
$49.80K - $67.60K/yr
By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...
Electron Microscopy Specialist
Hamilton, MT · On-site
$70K - $80K/yr
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
Electron Microscopy Specialist
Hamilton, MT · On-site
$70K - $80K/yr
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
Electron Microscopy Specialist
$70K - $80K/yr
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
Quick apply
Electron Microscopy Specialist
$70K - $80K/yr
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
If you have strong immuno-EM experience and are excited about learning and applying newer approaches like CLEM, FIB-SEM, and cryo-EM, this could be a great fit. What You'll Do * Prepare biological ...
Post-Doctoral Fellow
$49.80K - $67.60K/yr
Cryo-EM of large macromolecular assemblies * Biochemistry and molecular biology Current projects include: * Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange ...
Post-Doctoral Fellow
$49.80K - $67.60K/yr
Cryo-EM of large macromolecular assemblies * Biochemistry and molecular biology Current projects include: * Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange ...
Post Doctoral Associate (Ebright Lab)
Piscataway, NJ · On-site
$49.90K - $67.80K/yr
Uses cryo-ET, cryo-EM, and X-ray crystallography to define structures and structural transitions of transcription complexes and transcription-translation complexes and to identify and characterize ...
Post Doctoral Associate (Ebright Lab)
Piscataway, NJ · On-site
$49.90K - $67.80K/yr
Uses cryo-ET, cryo-EM, and X-ray crystallography to define structures and structural transitions of transcription complexes and transcription-translation complexes and to identify and characterize ...
Post Doctoral Associate (Ebright Lab)
$50.60K - $68.60K/yr
Uses cryo-ET, cryo-EM, and X-ray crystallography to define structures and structural transitions of transcription complexes and transcription-translation complexes and to identify and characterize ...
Post Doctoral Associate (Ebright Lab)
$50.60K - $68.60K/yr
Uses cryo-ET, cryo-EM, and X-ray crystallography to define structures and structural transitions of transcription complexes and transcription-translation complexes and to identify and characterize ...
Postdoctoral Research Associate - Structural Biology
Memphis, TN · On-site
$72.50K/yr
We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller ...
Postdoctoral Research Associate - Structural Biology
Memphis, TN · On-site
$72.50K/yr
We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller ...
Post-Doctoral Fellow
Aurora, CO · On-site
$49.80K - $67.60K/yr
Cryo-EM of large macromolecular assemblies * Biochemistry and molecular biology Current projects include: * Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange ...
Post-Doctoral Fellow
Aurora, CO · On-site
$49.80K - $67.60K/yr
Cryo-EM of large macromolecular assemblies * Biochemistry and molecular biology Current projects include: * Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange ...
Postdoctoral Associate - Structural Biology
Vestal, NY · On-site
$55K/yr
This research combines cryo-EM, biochemical and biophysical techniques, and cellular assays to investigate the structure and function of GPCRs (e.g. Nature Communications (2023), doi: 10.1038/s41467 ...
Postdoctoral Associate - Structural Biology
Vestal, NY · On-site
$55K/yr
This research combines cryo-EM, biochemical and biophysical techniques, and cellular assays to investigate the structure and function of GPCRs (e.g. Nature Communications (2023), doi: 10.1038/s41467 ...
Lab Specialist
Charlottesville, VA · On-site
Our lab uses a combination of biochemistry, mammalian and yeast cell systems, and advanced structural biology techniques such as cryo-EM and cryo-ET. The successful candidate will assist in: • ...
Lab Specialist
Charlottesville, VA · On-site
Our lab uses a combination of biochemistry, mammalian and yeast cell systems, and advanced structural biology techniques such as cryo-EM and cryo-ET. The successful candidate will assist in: • ...
Sr. Research Specialist II (Biophysics)
Baltimore, MD · On-site
$64.60K - $113.30K/yr
The Beckman Center for Cryo-EM is seeking a Sr. Research Specialist II who is an expert electron microscopist to support the center's operations in cryo-electron tomography (cryo-ET), focusing on ...
Sr. Research Specialist II (Biophysics)
Baltimore, MD · On-site
$64.60K - $113.30K/yr
The Beckman Center for Cryo-EM is seeking a Sr. Research Specialist II who is an expert electron microscopist to support the center's operations in cryo-electron tomography (cryo-ET), focusing on ...
These efforts combine cryo-EM and cryo-ET structural biology, biochemical and cellular assays, and mass spectrometry. The lab also explores bacterial defense mechanisms against bacteriophage ...
These efforts combine cryo-EM and cryo-ET structural biology, biochemical and cellular assays, and mass spectrometry. The lab also explores bacterial defense mechanisms against bacteriophage ...
Post Doctoral Scholar
Columbus, OH · On-site
Demonstrated expertise in cryo-electron microscopy (cryo-EM) and/or X-ray crystallography, supported by a strong publication record in peer-reviewed journals. Proven hands-on experience in ...
Post Doctoral Scholar
Columbus, OH · On-site
Demonstrated expertise in cryo-electron microscopy (cryo-EM) and/or X-ray crystallography, supported by a strong publication record in peer-reviewed journals. Proven hands-on experience in ...
Assistant Academic Research Scientist | School of Medicine - Pediatrics, Emory LOBP
Atlanta, GA · On-site
A central aspect of the role involves processing cryo-EM data to determine viral lattice structures and contribute to structural insights that inform antiviral strategies. KEY RESPONSIBILITIES:
Assistant Academic Research Scientist | School of Medicine - Pediatrics, Emory LOBP
Atlanta, GA · On-site
A central aspect of the role involves processing cryo-EM data to determine viral lattice structures and contribute to structural insights that inform antiviral strategies. KEY RESPONSIBILITIES:
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Postdoctoral Researcher - Pharmacology and Toxicology
Medical College of WisconsinMilwaukee, WI • On-site
Full-time
Medical, Dental, Vision, Retirement, PTO
Posted 17 days ago
Medical College Of Wisconsin rating
8.2
Based on 27 frontline employees who took The Breakroom Quiz
106th of 529 rated colleges and universities
Job description
A postdoctoral fellowship is available in the Zhu Lab at MCW to investigate the molecular mechanisms of membrane protein complexes, including their oligomerization, trafficking and cell signaling, using advanced structural biology approaches. The successful candidate will lead an independent research project focused on G protein-coupled receptors (GPCRs) and related membrane proteins, examining how receptor function is regulated by ligands, interacting partners, and the cellular environment. This work will integrate cryo-electron microscopy (cryo-EM), biochemical and cell biology assays, and computational modeling to elucidate mechanisms of cell signaling and inform the development of novel therapeutic strategies for human disease.
The laboratory provides a rich, interdisciplinary environment with established platforms including bacterial, insect, and mammalian protein expression systems; cryo-EM workflows; biochemical and cell biology techniques; and computational biology tools.
The postdoctoral fellow is strongly encouraged to apply for internal and external fellowship funding, including programs such as the MCW Cancer Center Postdoctoral and Clinical Fellowship Program and Postdoctoral Researcher Seed Grants. Continued support for this position will be based on annual performance review.
Characteristics of a postdoctoral appointment:
It is expected that postdocs at MCW, with the assistance of their supervisor, will:
- Transition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.
- Be supervised by at least one senior scholar who actively promotes the postdoc's professional development.
- Establish an individual development plan (IDP) that incorporates equally the postdoc's career and training goals and the mentor's research goals.
- Pursue basic or translational projects so long as effort is focused primarily on research.
- Publish results of the postdoc's research and scholarship during their appointment.
- The postdoctoral appointment is temporary by nature, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).
- As postdocs are important members of the host institution's community, appropriate levels of compensation, health care, and other benefits commensurate with their essential status should be afforded, independent of the postdoc's source of funding.
Primary Responsibilities
- Design, plan, and execute independent research projects on GPCRs and cell signaling.
- Perform membrane protein expression, purification, and structural studies using cryo-EM and/or crystallography.
- Apply computational modeling and integrate structural, biochemical, and cell biology data.
- Analyze and interpret experimental data; develop and optimize methodologies.
- Prepare manuscripts, reports, and presentations of research findings.
- Participate in lab meetings and collaborate with team members.
- Assist in grant writing and fellowship applications.
- Mentor and train junior lab members as appropriate.
- Maintain laboratory organization, supplies, and experimental workflows.
Knowledge - Skills - Abilities
Required Knowledge:
- Structural biology, biochemistry, biophysics, cell biology, computational biology, or related biomedical sciences
- Protein expression and purification techniques
- Data analysis, statistics, and scientific writing
- Complex problem solving and critical thinking
Preferred Skills and Abilities:
- Experience with cryo-EM single particle analysis and/or X-ray crystallography
- Familiarity with membrane protein biochemistry
- Computational modeling and structural analysis tools
- Strong organizational, communication, and collaboration skills
- Ability to work independently and manage multiple projects
Qualifications
Minimum Required Education: PhD in a scientific field
Minimum Required Experience: 0 years
Preferred Experience: Postdoc experiences in structural biology field is preferred.
Physical Requirements
Work requires occasionally lifting moderate weight materials, standing, or walking continuously.
Work Environment
Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.
Sensory Acuity
Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.
Why MCW?
- Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
- 403B Retirement Package
- Competitive Vacation and Paid Holidays offered
- Tuition Reimbursement
- Paid Parental Leave
- Employee & Family Assistance Program (EFAP)
- Pet Insurance
- On campus Fitness Facility, offering onsite classes
- Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.
For a brief overview of our benefits see: Benefits Overview
For a full list of positions see: MCW Careers
At MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring - Collaborative - Curiosity - Inclusive - Integrity - Respect. We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website.
MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination:
The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.
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About Medical College of Wisconsin
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The Medical College of Wisconsin (MCW) is an industry-leading educational institution located in Milwaukee, WI, US. Being part of the medical and health services sector, MCW's primary mission is to educate and train the next generation of healthcare professionals. MCW offers a wide array of degrees and programs within medical and health sciences, covering everything from medical, graduate, pharmacy and health sciences studies, to continuing professional developments and community engagement initiatives. Founded in 1893, MCW boasts a rich, well-entrenched history in shaping the medical education landscape locally and globally. The institution's core values of knowledge-changing life underline its dedication to incorporating innovative approaches in education and research, commitment to diversity and inclusion, service to the community, integrity, stewardship, and collaboration.
Industry
Health care and social assistance
Company size
5,001 - 10,000 Employees
Headquarters location
Milwaukee, WI, US
Year founded
1893