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What is a Cryo-EM postdoctoral position?

A Cryo-EM postdoctoral position is a research-focused role for individuals who have recently earned a Ph.D. and want to gain advanced experience using cryo-electron microscopy (Cryo-EM). These postdocs work in academic or research institutions to study the structure of biological molecules at near-atomic resolution. Responsibilities typically include sample preparation, data collection, image processing, and structural analysis. The goal is to contribute to scientific discoveries in fields such as structural biology, biochemistry, and drug development.

What are the key skills and qualifications needed to thrive as a Cryo-EM postdoctoral researcher?

To thrive as a Cryo-EM Postdoctoral Researcher, you need advanced knowledge in structural biology, electron microscopy techniques, and a PhD in a relevant field such as biochemistry or biophysics. Expertise in using cryo-electron microscopes, image processing software (e.g., RELION, CryoSPARC), and data analysis pipelines is typically required. Strong problem-solving abilities, attention to detail, and effective communication skills distinguish top candidates in this role. These qualifications are crucial for conducting high-quality research, collaborating across multidisciplinary teams, and advancing structural biology discoveries.

What are some common challenges faced by postdoctoral researchers working with Cryo-EM, and how can they be addressed?

Postdoctoral researchers in Cryo-Electron Microscopy (Cryo-EM) often face challenges such as optimizing sample preparation, handling large datasets, and troubleshooting instrument issues. Mastering the intricacies of sample vitrification and grid preparation is crucial, as poor samples can hinder data collection. Additionally, managing and processing extensive datasets requires familiarity with specialized software and computational resources. Collaborating closely with experienced lab members, attending relevant workshops, and staying updated with the latest protocols can help overcome these challenges and accelerate research progress.

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Cryo Em Postdoctoral Position jobs near you
Infographic showing various Cryo Em Postdoctoral Position job openings in California as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 13% Part Time, and 2% Contract. Highlights an 88% Physical, 2% Hybrid, and 10% Remote job distribution.

Postdoctoral Researcher - Zhou Lab

Buck Institute for Research on Aging

Novato, CA • On-site

$73K - $81K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 13 days ago

Job description

Ribosome Biogenesis and Function
Position Summary
The Buck Institute for Research on Aging is seeking a highly motivated Postdoctoral Researcher to investigate the mechanisms governing ribosome biogenesis, remodeling, and function. Projects may focus on cytosolic and/or mitochondrial ribosomes and address questions related to ribosome assembly, composition, structure, localization, and translational activity.
The successful candidate will develop a mechanistic research program using one or more complementary approaches, including biochemistry, quantitative imaging, cryo-electron microscopy, and cryo-electron tomography. Applicants are not expected to have expertise in all these areas. Candidates with deep experience in ribosomes are strongly encouraged to apply, and the project will be shaped around the candidate's scientific strengths, interests, and career goals.
Potential research directions include:
  • Defining ribosome assembly pathways, intermediates, and quality-control mechanisms.
  • Visualizing the spatial and temporal organization of ribosome biogenesis and function in living cells.
  • Linking genetic and biochemical perturbations to ribosome structure using cryo-EM and cryo-electron tomography.
  • Understanding how metabolism and stress remodel ribosomes.

About the Zhou Lab
The Zhou Lab studies how the cellular proteome changes its organization and function in response to environmental conditions, stress, and aging. We use model systems ranging from budding yeast to cultured human cells. The lab combines molecular and cell biology, biochemistry, quantitative proteomics, high-throughput screening, automated and super-resolution microscopy, cryo-EM/cryo-ET, computational analysis, and machine learning. Our multidisciplinary team includes researchers with backgrounds in biology, biophysics, and artificial intelligence.
The successful candidate will receive close scientific mentorship while being encouraged to develop intellectual independence. The Buck provides access to advanced core facilities, a highly collaborative aging-research community, and professional-development opportunities in scientific writing, fellowship applications, presentations, leadership, and career planning.
Required Qualifications
  • PhD completed by the start date in molecular cell biology, biochemistry, structural biology, biophysics, or a related field.
  • Strong research experience in relevant approach, such as biochemistry, quantitative imaging, cryo-EM/cryo-ET.
  • Evidence of rigorous and productive research, including first-author publications.
  • Ability to design and execute experiments, analyze quantitative data, and troubleshoot independently.
  • Ability to work collaboratively in a multidisciplinary environment and communicate effectively in written and spoken English.

Preferred Experience
  • Prior work on ribosomes, translation, proteostasis, or macromolecular-complex assembly.
  • Experience with budding yeast or mammalian cell culture, protein purification, ribosome profiling, quantitative proteomics, fluorescence microscopy, or single-particle cryo-EM.
  • Interest in learning complementary methods and in integrating mechanistic experiments across scales.

Selected Recent Publications
Zheng F, et al. Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis. Molecular Cell. 2025.
Liu Q, et al. Mitochondria-lysosome coupling contributes to lysosome acidification and aging. Molecular Cell. 2026.
Yoo S, et al. The spatiotemporal proteome landscape of aging: Structural determinants of age-sensitive proteome remodeling. bioRxiv. 2026. doi:10.64898/2026.02.26.708310.
Liu Q, et al. Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface. Proceedings of the National Academy of Sciences USA. 2023;120:e2300475120.
Compensation and Benefits
  • $73,760 - $81,440 annually, depending on qualifications and experience
  • Comprehensive benefits include medical, dental, and vision coverage; paid time off and parental leave; a 401(k) employer contribution; and a student-debt repayment option.

About the Buck Institute
The Buck Institute is the first independent biomedical research institute in the United States devoted solely to research on aging. Located in Novato, California, the Buck brings together scientists across disciplines to study the mechanisms of aging and age-related disease and to help people live better, longer.
The Buck Institute is an equal opportunity employer. We strongly encourage applications from candidates whose experiences and perspectives will contribute to the diversity and excellence of our community.
To Apply
Please submit the following through the Buck Institute careers portal:
  • A curriculum vitae
  • A cover letter describing your prior research, the ribosome questions or projects that most interest you, and how this position fits your future goals
  • Contact information for three professional references
  • Representative publications or other relevant research products, as appropriate.

Learn more about the Zhou Lab: www.buckinstitute.org/lab/zhou-lab/

Apply