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Computer Systems Validation Jobs in California (NOW HIRING)

Nvidia

Systems Validation Engineer

Santa Clara, CA

We pioneered a supercharged form of computing loved by the most demanding computer users in the ... We are looking for a Systems Validation Engineer in the Datacenter Systems Engineering team. You'll ...

Apple

GNSS Systems Validation Engineer

Sunnyvale, CA · On-site

As a GNSS Systems Validation Engineer, you will be a key member of Apple's cellular team, driving ... MS or PhD in Electrical or Computer Engineering is a plus.Strong verbal and written communication ...

Apple

Wireless Systems Validation Engineer

Irvine, CA

$171K - $302K/yr

Description Join our Wireless Systems Design Validation Team, where we ensure cutting-edge wireless ... Preferred Qualifications Advanced degree in Electrical Engineering or Computer Engineering; Master ...

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Computer Systems Validation information

See California salary details

$10

$53

$84

How much do computer systems validation jobs pay per hour?

As of Jun 9, 2026, the average hourly pay for computer systems validation in California is $53.61, according to ZipRecruiter salary data. Most workers in this role earn between $41.30 and $63.56 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Computer Systems Validation, and why are they important?

To thrive in Computer Systems Validation, you need a solid understanding of regulatory requirements (such as FDA or EMA guidelines), software development life cycles, and risk management, often supported by a degree in life sciences, IT, or engineering. Experience with validation frameworks, documentation tools, and systems like GAMP 5 and knowledge of 21 CFR Part 11 compliance are typically required. Attention to detail, strong analytical thinking, and effective communication set professionals apart in this role. These skills and qualifications ensure validated systems are compliant, reliable, and support organizational quality and regulatory objectives.

What is the difference between Computer Systems Validation vs Quality Assurance Specialist?

AspectComputer Systems ValidationQuality Assurance Specialist
CertificationsGAMP, CSV-specific trainingISO 9001, Six Sigma
Work EnvironmentRegulated industries like pharma, biotechManufacturing, software, service sectors
Primary FocusEnsuring computer systems meet regulatory standardsEnsuring overall product/service quality
Common UsageValidation of software, hardware in complianceProcess audits, quality improvement

Computer Systems Validation and Quality Assurance Specialist roles overlap in ensuring compliance and quality. However, CSV focuses specifically on validating computer systems to meet regulatory standards, especially in pharma and biotech industries. Quality Assurance Specialists have a broader scope, overseeing overall quality processes across various sectors. Both roles require similar certifications and work environments but differ in their primary objectives and specific tasks.

What is computer systems validation?

Computer systems validation (CSV) is the process of ensuring that computer-based systems used in regulated industries, like pharmaceuticals and biotechnology, perform their intended functions consistently and reliably. This process involves documenting and testing systems to confirm they meet regulatory requirements, such as those set by the FDA. The goal is to ensure data integrity, product quality, and patient safety by minimizing the risk of system errors or failures. CSV typically includes activities like risk assessment, test planning, execution, and maintaining thorough records for audits.

What are some common challenges faced in a Computer Systems Validation (CSV) role, and how can they be addressed?

Professionals in Computer Systems Validation often encounter challenges such as keeping up with evolving regulatory requirements, managing documentation for multiple systems, and coordinating with cross-functional teams. Staying updated through regular training and industry resources helps address compliance changes. Clear communication and collaboration with IT, Quality Assurance, and business stakeholders are essential for efficient validation processes. Utilizing validation lifecycle management tools and standardized templates can also streamline documentation and reduce errors.
What are popular job titles related to Computer Systems Validation jobs in California? For Computer Systems Validation jobs in California, the most frequently searched job titles are:
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What cities in California are hiring for Computer Systems Validation jobs? Cities in California with the most Computer Systems Validation job openings:
Computer Systems Validation jobs near you
Infographic showing various Computer Systems Validation job openings in California as of June 2026, with employment types broken down into 1% As Needed, 79% Full Time, 13% Part Time, and 7% Contract. Highlights an 88% Physical, 4% Hybrid, and 8% Remote job distribution, with an average salary of $111,503 per year, or $53.6 per hour.
Senior Computer Systems Validation Engineer

Senior Computer Systems Validation Engineer

Vaxcyte

San Carlos, CA • Hybrid

$164K - $190K/yr

Other

Posted 14 days ago

Job description

Summary:

The Senior Computer Systems Validation (CSV) Engineer is responsible for leading validation activities for cloud based GxP systems to ensure they meet regulatory, quality, and operational requirements throughout the system lifecycle. The role focuses on traditional Computer System Validation with application of risk-based Computer Software Assurance (CSA) principles where appropriate.

The individual will work closely with IT and Quality teams to validate and maintain GxP systems across their lifecycle. Strong experience validating relational databases, cloud infrastructure, and integrated applications in regulated biotech or pharmaceutical environments is required.

This is a hands-on role requiring authoring and executing validation documents and protocols for GAMP 5 systems.

This is a hybrid role with minimum of 3 days a week onsite at San Carlos, CA location.

Essential Functions:
  • Hands-on lead full lifecycle Computer System Validation activities for cloud based GxP systems including databases, and applications.
  • Author, update, execute and maintain validation deliverables such as Validation Plans, User Requirements, Functional Specifications, Risk Assessments, Traceability Matrices, IQ, OQ, PQ protocols, and Summary Reports.
  • Perform risk assessments to define validation scope, testing strategy, and documentation requirements in alignment with CSA principles.
  • Define and execute validation strategies for data platforms and system components, ensuring systems meet defined functional, security, and data integrity requirements
  • Assess and validate end to end data flows between upstream source systems and downstream applications to ensure accuracy, completeness, and traceability.
  • Evaluate system changes for validation impact and ensure validated systems remain compliant through appropriate testing and documentation.
  • Ensure validation activities align with automated build and deployment pipelines, confirming that system releases maintain validated state and appropriate validation evidence is generated.
  • Support change control, deviation management, periodic review, and lifecycle management of validated systems.
  • Participate in internal audits and regulatory inspections, providing validation documentation and rationale as required.
  • Contribute to continuous improvement of validation procedures aligned with evolving CSA guidance and cloud delivery models.
Requirements: 
  • Bachelor's degree in Computer Science, Engineering, Life Sciences, or related field, or equivalent professional experience.
  • Minimum 7 years of experience in Computer System Validation within biotech manufacturing and lab data systems. Other combinations of education and/or experience may be considered.
  • Must have technical knowledge of IT infrastructure, software engineering, programming, databases and data integrations.
  • Experience working in modern system environments utilizing CI/CD pipelines or automated release processes.
  • Strong hands-on experience validating GAMP 5 systems for biotech manufacturing.
  • Deep understanding of FDA 21 CFR Part 11, Part 210, Part 211, Annex 11, data integrity requirements, and risk-based validation methodologies.
  • Strong technical writing skills and ability to create comprehensive validation documentation.
  • Ability to communicate validation risks and requirements clearly to IT and Quality stakeholders.

Other combinations of education and/or experience may be considered.

Preferred Qualifications:

  • Hands-on experience validating cloud based GxP systems, specifically Azure.
  • Familiarity with infrastructure as code frameworks like GitHub, Terraform etc.
  • Experience applying CSA principles to custom data applications in GxP cloud.
  • Microsoft Azure or similar technical certifications.
Reports to: Senior Manager, Data Systems
 
Location: San Carlos, CA
 
Work Arrangement: Hybrid (minimum of 3 days per week)
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $164,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary.
 
Relocation: 
This role is not eligible for relocation assistance. 
 
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About Vaxcyte

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

San Carlos, CA, US

Year founded

2013

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