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Commission Downstream Process Development Jobs (NOW HIRING)

Legend Biotech USA, Inc.

Role OverviewThe Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for ...

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As of May 31, 2026, the average hourly pay for commission downstream process development in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.
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Infographic showing various Commission Downstream Process Development job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 79% Full Time, 19% Part Time, and 1% Contract. Highlights an 93% Physical, and 7% Remote job distribution, with an average salary of $70,060 per year, or $33.7 per hour.

Associate Scientist, Downstream Process Development

Epicrispr Biotechnologies

South San Francisco, CA • On-site

$118K - $124K/yr

Other

Posted 3 days ago

Job description

Title: Associate Scientist, Downstream Process Development

Location: South San Francisco, CA

Opportunity:

We are seeking a highly motivated and detail-oriented Associate Scientist to join the Downstream Process Development team focused on adeno-associated virus (AAV) gene therapy therapeutics. This role will support the development, optimization, and scale-up of purification processes for AAV vectors from early research through clinical manufacturing.

Responsibilities:

  • Design, execute, and analyze downstream purification experiments for AAV vectors for process steps including clarification, sterile filtration, tangential flow filtration (TFF), chromatography (affinity, ion exchange, size exclusion, mixed mode), and ultracentrifugation.
  • Perform small-scale studies for development of downstream AAV processes, process optimization, process characterization, and assessment of process robustness.
  • Support process development activities from bench scale through pilot scale and tech transfer to GMP manufacturing.
  • Present data and project updates in team meetings and cross-functional forums.
  • Maintain accurate and timely documentation in electronic lab notebooks and technical reports.
  • Collaborate cross-functionally with upstream process development and analytical development and other functions.
  • Stay current with advancements in AAV purification technologies, regulatory expectations, and industry best practices.

Qualifications:
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

  • B.S. degree in Biochemical Engineering, Chemical Engineering, Molecular Biology, Biotechnology, Biochemistry, or related discipline with 5+ years of relevant industry experience (or M.S. with 3+ years or Ph.D.)
  • Required experience with AKTA purification
  • Strong working knowledge of chromatography and filtration technologies
  • Hands-on experience with viral vector purification, preferably AAV
  • Experience with analytical techniques for AAV characterization such as Refeyn, qPCR/dPCR/ddPCR, ELISA, alkaline gel, CE-SDS, SEC-HPLC, AUC and other similar analytical assays
  • Familiarity with Design of Experiments (DOE) and JMP are a plus
  • Strong organizational, analytical, and problem-solving skills
  • Excellent written and verbal communication skills

Compensation: The salary range for this position is $118,000 to $124,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location. 

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