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Clinical Research Operations Manager Jobs in Missouri

Washington University of St. Louis

Direct the day-to-day operations of the Clinical Trials Office, including the direct supervision, mentorship, and performance evaluation of the Clinical Research Manager. * Oversee cross-functional ...

Washington University of St. Louis

$60K - $99K/yr

Clinical Research, Clinical Research Coordination, Clinical Research Management, Clinical Research Methods, Clinical Research Operations, Clinical Techniques, Critical Thinking, Database Management ...

Washington University of St. Louis

$60K - $99K/yr

Clinical Research, Clinical Research Coordination, Clinical Research Management, Clinical Research Methods, Clinical Research Operations, Clinical Techniques, Critical Thinking, Database Management ...

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$32.8K

$92K

$174.9K

How much do clinical research operations manager jobs pay per year?

As of Aug 29, 2026, the average yearly pay for clinical research operations manager in Missouri is $91,961.00, according to ZipRecruiter salary data. Most workers in this role earn between $68,000.00 and $106,500.00 per year, depending on experience, location, and employer.

What does a clinical research operations manager do?

A Clinical Research Operations Manager oversees the daily operations of clinical trials to ensure they are conducted efficiently, ethically, and in compliance with regulatory standards. They coordinate between research staff, sponsors, and regulatory bodies, manage budgets and timelines, and ensure proper documentation and reporting. Their role is essential in maintaining the quality and integrity of clinical studies from start to finish.

How does a clinical research operations manager collaborate with cross-functional teams during a study?

As a Clinical Research Operations Manager, you will work closely with cross-functional teams including clinical trial coordinators, data managers, regulatory affairs specialists, and principal investigators. Your role involves facilitating clear communication between departments, ensuring that study milestones are met, and resolving operational issues as they arise. Regular meetings and status updates are common, and you'll often act as a liaison to keep all stakeholders aligned on study objectives, timelines, and compliance requirements. This collaborative approach is crucial for maintaining study integrity and ensuring successful trial outcomes.

What are the key skills and qualifications needed to thrive as a clinical research operations manager, and why are they important?

To thrive as a Clinical Research Operations Manager, you need a solid background in clinical research, regulatory compliance, and project management, often supported by a degree in life sciences or a related field. Familiarity with clinical trial management systems (CTMS), Good Clinical Practice (GCP) guidelines, and certifications such as ACRP or SOCRA are highly valuable. Leadership, problem-solving, and excellent organizational and communication skills help you manage teams and collaborate effectively with stakeholders. These skills and qualities are crucial for ensuring the successful execution of clinical trials while maintaining regulatory standards and operational efficiency.

What are popular job titles related to Clinical Research Operations Manager jobs in Missouri?

For Clinical Research Operations Manager jobs in Missouri, the most frequently searched job titles are:

What job categories do people searching Clinical Research Operations Manager jobs in Missouri look for?

The top searched job categories for Clinical Research Operations Manager jobs in Missouri are:

What cities in Missouri are hiring for Clinical Research Operations Manager jobs?

Cities in Missouri with the most Clinical Research Operations Manager job openings:

Clinical Research Operations Manager jobs near you
Infographic showing various Clinical Research Operations Manager job openings in Missouri as of August 2026, with employment types broken down into 88% Full Time, 9% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $91,961 per year, or $44.2 per hour.

Clinical Research Coordinator

Forefront Dermatology

Wentzville, MO • On-site

$23.25 - $31/hr

Full-time

Posted yesterday

New

Forefront Dermatology rating

5.7

Company rating: 5.7 out of 10

Based on 83 frontline employees who took The Breakroom Quiz

791st of 895 rated healthcare providers

Job description

Overview

The Clinical Research Coordinator drives clinical research strategy and execution across assigned studies and programs. Responsible for directing study operations, ensuring regulatory compliance, and delivering performance outcomes related to enrollment, data quality, and protocol execution. Engages directly with research participants and exercises independent judgment in identifying risks and implementing strategies that impact study success and organizational research objectives across sites.

Please note that this is a 100% on-site position in St. Peters, Missouri. Relocation assistance is not available for this role.


Responsibilities
  • Direct Clinical Research Operations across assigned protocols. Establish workflows, coordinate protocol-specific deliverables, and ensure studies execute in accordance with protocol requirements, regulatory standards, and organizational expectations.
  • Manage Regulatory Compliance and Data Integrity. Direct preparation and submission of regulatory documentation, oversee safety reporting obligations, and implement corrective actions to maintain audit readiness.
  • Lead Enrollment and Participant Engagement. Drive participant recruitment strategy, optimize screening and enrollment workflows, and meet study performance targets while ensuring positive participant experience and retention.
  • Own and Direct External Research Partnerships. Serve as the primary point of contact for sponsors, investigators, and CROs, driving study feasibility, site selection decisions, and resolution of operational issues.
  • Support and Develop the Research Enterprise. Mentor research team members, reinforce protocol standards across sites, and contribute to the operational growth and consistency of the broader research business unit.
  • Lead Protocol Planning and Feasibility Assessments. Evaluate new study opportunities, assess site capabilities and resource requirements, and provide strategic recommendations that inform protocol development and research program growth.

Qualifications
  • Advanced knowledge of clinical research regulations, quality management principles, and documentation standards, with ability to interpret and apply requirements to maintain compliance and audit readiness.
  • Demonstrated ability to exercise independent judgment in managing multiple studies, establishing priorities, and driving performance outcomes across research operations.
  • Ability to analyze study performance metrics, identify improvement opportunities, and implement operational enhancements that impact enrollment, compliance, and data quality.
  • Effective communication and interpersonal skills for interaction with sponsors, CROs, investigators, participants, and organizational leadership.

Required Education: Bachelor's Degree

Other Licensures or Certifications not Listed: Professional certification through the Association of Clinical Research Professionals or Society of Clinical Research Associates preferred

Minimum Years Related Experience: 4-6 Years

Physical Demands

  • Sitting for extended periods
  • Manual dexterity for typing and computer use
  • Visual acuity for reading screens and documents
  • Verbal communication via phone or in person
Forefront Dermatology is committed to providing equal employment opportunity and maintaining a workplace for employees and applicants that is free from discrimination based upon age, race, religion, color, disability, marital status, sex (including pregnancy), national origin, ancestry, ethnicity, sexual orientation, gender identity or expression, genetic information, veteran or military status, or any other status protected by applicable federal, state, or local law. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, please contact hr@forefrontderm.com to let us know the nature of your request and your contact information.Qualifications:
  • Advanced knowledge of clinical research regulations, quality management principles, and documentation standards, with ability to interpret and apply requirements to maintain compliance and audit readiness.
  • Demonstrated ability to exercise independent judgment in managing multiple studies, establishing priorities, and driving performance outcomes across research operations.
  • Ability to analyze study performance metrics, identify improvement opportunities, and implement operational enhancements that impact enrollment, compliance, and data quality.
  • Effective communication and interpersonal skills for interaction with sponsors, CROs, investigators, participants, and organizational leadership.

Required Education: Bachelor's Degree

Other Licensures or Certifications not Listed: Professional certification through the Association of Clinical Research Professionals or Society of Clinical Research Associates preferred

Minimum Years Related Experience: 4-6 Years

Physical Demands

  • Sitting for extended periods
  • Manual dexterity for typing and computer use
  • Visual acuity for reading screens and documents
  • Verbal communication via phone or in person
Education:UNAVAILABLEEmployment Type: FULL_TIME

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