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Clinical Research Line Manager information

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$49K

$107.3K

$189K

How much do clinical research line manager jobs pay per year?

As of Sep 14, 2026, the average yearly pay for clinical research line manager in the United States is $107,336.00, according to ZipRecruiter salary data. Most workers in this role earn between $81,000.00 and $122,500.00 per year, depending on experience, location, and employer.

What does a clinical research line manager do?

A Clinical Research Line Manager oversees a team of clinical research professionals, such as clinical research associates (CRAs) or coordinators, ensuring that clinical trials are conducted in compliance with regulatory standards and company protocols. They are responsible for mentoring, training, and evaluating staff performance, as well as managing workloads and supporting career development. Additionally, they may collaborate with project managers and other stakeholders to allocate resources and resolve operational challenges.

What are some common challenges clinical research line managers face when balancing project deadlines with team workloads?

Clinical Research Line Managers often navigate tight study timelines while ensuring their teams aren’t overwhelmed. One common challenge is balancing resource allocation so that multiple projects progress smoothly without overburdening staff or compromising data quality. Managers must regularly communicate with clinical research associates, project managers, and sponsors to adjust priorities and address unexpected issues such as protocol amendments or staffing changes. Effective time management, proactive problem-solving, and fostering open communication are key to overcoming these challenges.

What are the key skills and qualifications needed to thrive as a clinical research line manager, and why are they important?

To thrive as a Clinical Research Line Manager, you need a strong background in clinical research processes, regulatory compliance, and team leadership, typically supported by a degree in life sciences or a related field. Familiarity with clinical trial management systems (CTMS), Good Clinical Practice (GCP) guidelines, and, often, certifications like ACRP or SOCRA are important. Excellent communication, organizational, and conflict resolution skills help you effectively lead teams and coordinate with stakeholders. These skills ensure studies are conducted efficiently, ethically, and in accordance with regulatory standards, which is critical for successful clinical research outcomes.

What is the difference between Clinical Research Line Manager vs Clinical Research Associate?

AspectClinical Research Line ManagerClinical Research Associate
CredentialsBachelor's or higher in life sciences, often with project management experienceBachelor's in life sciences or related field, often with clinical research certifications
Work EnvironmentOversees multiple projects, manages teams, and coordinates with stakeholdersMonitors clinical trials at sites, ensures protocol compliance, and collects data
Employer & Industry UsagePharmaceutical companies, CROs, biotech firmsClinical trial sites, CROs, pharmaceutical companies

The Clinical Research Line Manager focuses on overseeing multiple clinical projects and managing teams, while the Clinical Research Associate primarily monitors individual trial sites to ensure compliance. Both roles require relevant certifications and are integral to the clinical research process, but they differ in scope and responsibilities.

What are popular job titles related to Clinical Research Line Manager jobs?

For Clinical Research Line Manager jobs, the most frequently searched job titles are:

Infographic showing various Clinical Research Line Manager job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 69% Full Time, 20% Part Time, 1% Temporary, and 9% Contract. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $107,336 per year, or $51.6 per hour.

Clinical Research Systems Manager

Phoenix, AZ • On-site

Arizona Arthritis & Rheumatology Associates
See more jobs at Arizona Arthritis & Rheumatology Associatesexternal

Full-time

Posted 25 days ago

Job description

Arizona Arthritis & Rheumatology Associates, P.C. is the largest private Rheumatology practice in the United States. The practice has over 60 providers, 15 sites and over 400 employees providing assessments and treatments for our rheumatology patients. Our providers work together to keep patients healthy and are recognized for excellence in medicine and for being pioneers in new treatments, ably supported by our Research department.
We are an equal employment opportunity employer and will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability.
Our vision is to provide the best Rheumatology care, anywhere and to balance sustainable operation with the highest possible level of patient care.
We are seeking an ambitious, friendly, positive, and compassionate Clinical Research Systems Manager to join our Team.
The Clinical Research Systems Manager reports to the Director of Clinical Research and is responsible for leading the research technology team and overseeing the design, implementation, maintenance, and quality of all clinical research technology systems across AARA Clinical Research.
RESPONSIBILITIES
  • First-line manager (direct, supervise, and evaluate) for the Research Systems Administrator, Research Systems Quality Specialist, and Data Developer
  • Conduct training, mentorship, and professional development of research technology staff, ensuring their success
  • Assign tasks, projects, and priorities to ensure balanced workloads and timely deliverables across the team
  • Meet with direct reports regularly to review metrics, conduct team huddles, and provide ongoing performance feedback
  • Perform HR responsibilities including interviews, reviews, reprimands, and terminations
  • Maintain a professional, courteous, and supportive communication style with all team members, stakeholders, and end users, fostering a positive and collaborative work environment
  • Define and execute the strategic vision for clinical research technology systems, aligning with organizational goals and growth
  • Oversee the design, implementation, and maintenance of enterprise clinical research technology systems including Advarra eSource/EDC, CTMS (Clinical Conductor), eRegulatory (Veeva SiteVault), Microsoft 365, Monday.com, and related platforms
  • Manage system quality, security, and privacy risks while ensuring ongoing compliance with protocols, SOPs, ICH-GCP, FDA requirements, contractual obligations, privacy laws, and HIPAA
  • Ensure all system builds, configurations, and integrations meet quality, security, and compliance standards before release
  • Ensure all analytics systems perform as expected, including metrics, dashboards, and operational reporting systems using SQL, Power Query, Power BI, and related analytics tools
  • Promote data integrity and quality standards among all system end users
  • Collaborate with clinical, operational, regulatory, and administrative teams to translate organizational needs into easy-to-use technology solutions
  • Identify system gaps and inefficiencies, perform root cause analysis, and implement solutions to improve overall organizational performance
  • Ensure ongoing provision of accurate training materials, guides, SOPs, and documentation for all electronic systems
  • Serve as the systems escalation point for customers, vendors, and internal stakeholders
  • Support audits, inspections, and monitoring activities related to electronic systems and data management
  • Stay current with emerging clinical research technologies, AI/automation tools, local and federal laws, internal policies, and industry best practices to drive innovation
  • Perform additional duties as assigned by the Director of Clinical Research

Learn more about AARA on our website at http://azarthritis.com
Requirements
Essential
  • Bachelor's Degree or equivalent; preferably in Computer Science, Information Technology, Health Informatics, or related field
  • Minimum of 3 years of experience in clinical research technology systems management or administration
  • Minimum of 2 years of supervisory or team leadership experience
  • Strong knowledge of clinical trial protocols, electronic source, CTMS, regulatory, and project management systems architecture
  • Familiarity with FDA regulations, ICH-GCP guidelines, network security, and HIPAA compliance
  • Excellent leadership, project management and communication skills
  • Able to travel up to 20% domestically

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