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Clinical Database Programmer Jobs in Durham, NC (NOW HIRING)

Cardinal Health

Senior Data/AI Engineer

Raleigh, NC · Remote

$103K - $140K/yr

Specialty Networks solutions include population health management, patient engagement, clinical ... Job Summary The Senior Data/AI Engineer is a senior individual contributor on the Data & AI ...

Metasys Technologies

AI Engineer

Raleigh, NC · On-site

... clinical, and business operations in a regulated healthcare/life sciences environment. Key ... Build RAG-based applications using vector databases, embeddings, and semantic search. * Design AI ...

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Duke Clinical Research Institute

AI Engineer

Durham, NC · Hybrid

$110.60K - $132.90K/yr

AI Engineer Data Analytics Practice | Office of Information Technology Be You. The Office of ... Experience with retrieval-augmented generation (RAG) , embeddings, vector databases, and semantic ...

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Clinical Database Programmer information

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$63K

$107.8K

$192.1K

How much do clinical database programmer jobs pay per year?

As of May 28, 2026, the average yearly pay for clinical database programmer in Durham, NC is $107,788.00, according to ZipRecruiter salary data. Most workers in this role earn between $72,500.00 and $163,100.00 per year, depending on experience, location, and employer.

What is a Clinical Database Programmer job?

A Clinical Database Programmer is responsible for designing, developing, and maintaining databases used in clinical trials. They ensure that data is collected, stored, and managed efficiently while complying with regulatory standards such as CDISC and FDA guidelines. Their role involves creating database structures, writing validation checks, and supporting data analysis to ensure accurate and reliable clinical trial results. They often work with clinical data managers, biostatisticians, and regulatory teams.

What are the key skills and qualifications needed to thrive in the Clinical Database Programmer position, and why are they important?

To excel as a Clinical Database Programmer, you need a bachelor's degree in computer science or a related field, experience in database design, and a strong understanding of clinical data standards. Proficiency in database management systems (such as Oracle or SQL), knowledge of electronic data capture (EDC) tools like Medidata Rave, and familiarity with programming languages like SAS or SQL are commonly required, along with certifications such as CDISC or Medidata Solutions. Attention to detail, problem-solving ability, and strong communication skills are valuable soft skills for this role. Mastering these competencies is vital for ensuring high-quality, regulatory-compliant clinical trial data and effective collaboration within multidisciplinary research teams.

What are common responsibilities and team interactions for a Clinical Database Programmer in a typical workweek?

As a Clinical Database Programmer, your primary responsibilities usually include designing, building, and validating clinical trial databases, ensuring data is collected and managed in compliance with industry standards and regulatory requirements. You will frequently collaborate with clinical data managers, biostatisticians, and study coordinators to define data collection requirements and resolve data discrepancies. Team meetings and cross-functional communication are integral parts of the role, as you work together to maintain database integrity throughout the study lifecycle. This collaborative environment provides valuable experience in both technical problem-solving and teamwork, often paving the way for advancement into senior programming or data management positions.
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Clinical Database Programmer jobs near you
Infographic showing various Clinical Database Programmer job openings in Durham, NC as of May 2026, with employment types broken down into 3% As Needed, 89% Full Time, 1% Part Time, and 7% Contract. Highlights an 71% Physical, 6% Hybrid, and 23% Remote job distribution, with an average salary of $107,788 per year, or $51.8 per hour.

Freelance Principal Database Programmer

TFS HealthScience

Durham, NC • On-site, Remote

Contractor

Posted 24 days ago

Job description

Principal Database Programmer - 0.5 FTE FREELANCE (UK/POLAND/USA)
TFS HealthScience is a leading global mid-size Contract Research Organization (CRO) that partners with biotechnology and pharmaceutical companies throughout their entire clinical development journey. Our expertise includes full service-capabilities, resourcing and Functional Service (FSP) solutions.
Join Our Team as a Principal Database Programmer
About this role
As part of our CDS Ophthalmology team you will working alongside passionate and innovative professionals to ensure our customers achieve their goals.
The Principal Database Programmer is part of the Global Biometrics Department within Clinical Development and will work operationally on preparing, conducting and completing Clinical Data Management tasks on assigned Study Teams, according to company policies, SOPs and regulatory requirements.
Key Responsibilities:
• Provide training and mentoring to (Senior) Database Programmers related to CDMS systems and processes to be performed by Database Programmers
• Plan client deliverables and manage project budgets
• Act as programming lead for a study/ program
• Setup of study databases and ePRO/ IRT (if applicable) based on provided specifications (e.g. dummy CRF pages, study design specification, URS)
• May write or review the Database Validation Plan
• Perform database validation/ UAT in collaboration with CDM
• May review Data Validation Plan (DVP) with regards to feasibility of checks in CDMS
• Program edit checks within CDM systems and/ or SAS according to data validation plan
• May write or support CDM with creation of edit check test plan
• May perform or support CDM with import and export of data
• May write or support CDM with creation of data transfer specifications including liaising with vendors to facilitate connections between CDMS and other systems
• May perform or support CDM with validation of Data transfer programming
• Create and manage users incl. access rights (if applicable)
• Provide helpdesk for users in EDC studies
• Perform the execution of the database lock in collaboration with CDM
• File/ archive essential documents
• Responsible to escalate any issues on projects or the need for potential SOP deviations
• Perform system validation, create test scripts for system validation as well as perform UAT
• Actively contribute to the organization and development of processes to enhance the work at TFS (e.g. writing/ review of SOPs including related documents and perform training)
• Provide input into proposals which include Data Management and may attend Bid Defense meetings
Qualifications:
  • Bachelor's Degree, preferably in life science, computer science or equivalent
  • Minimum of 8 years relevant database programming experience in pharmaceutical or CRO industry, including 5 years as Senior Database Programmer
  • Familiarity with different CDMS systems and industry standards applicable for programming in GxP environment (e.g. 21 CFR part 11, GAMP)
  • Ability to handle multiple tasks to meet deadlines
  • Proven leadership skills
  • Excellent verbal and communication skills
  • Ability to deal effectively with sponsors and internal customers
  • Ability and willingness to travel on occasion

We provide a competitive compensation package, comprehensive benefits and the opportunity for personal and professional growth in a rewarding environment. You'll be joining a team that values collaboration, innovation, and making a difference in the lives of patients
A Bit More About Us
Our journey began over 30 years ago in Sweden, in the city of Lund. As a full-service, global Contract Research Organization (CRO), we build solution-driven teams working towards a healthier future. Bringing together over 600 professionals, TFS delivers tailored clinical research services in more than 50 countries with flexible clinical development and strategic resourcing solutions across key therapeutic areas including Dermatology, Neuroscience, Oncology and Ophthalmology.
Our core values of Trust, Quality, Passion, Flexibility, and Sustainability are our guiding light serving as the framework for decision-making at all levels of the organization. They assist us in attracting and retaining valuable talent who share our sentiments, resulting in high employee engagement and satisfaction. By aligning on these fundamental values, we cultivate a unified force, geared towards innovation and excellence. This collective effort propels us towards our shared goal and fosters a culture of mutual respect and collaboration.
Together we make a difference.
Department CDS Ophthalmology Locations Multiple locations Remote status Fully Remote Employment type Contract Work Arragement Remote REQ ID reqID483988

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