Chief Of Staff Project Management Jobs (NOW HIRING)

DefinedTalent is partnering with a rapidly growing, venture-backed AI company that is transforming how complex, highly regulated industries leverage automation, intelligence, and scalable technology.

Already working with enterprise clients and industry leaders, this organization is building innovative AI-driven solutions that have the potential to fundamentally reshape how critical business processes are executed. As they enter their next phase of growth, they are seeking a highly driven Chief of Staff to work directly alongside the CEO and executive leadership team.

This is not a traditional Chief of Staff role focused on coordination and administration. This is a builder and operator role designed for someone who thrives in fast-paced environments, enjoys solving complex challenges, and wants a front-row seat to scaling a category-defining company.

The Chief of Staff will serve as a strategic partner to the CEO, helping drive execution across company-wide initiatives, operations, growth strategy, fundraising efforts, partnerships, and organizational scaling.

The ideal candidate is equally comfortable in the boardroom and in the trenches, someone who can move seamlessly between strategic planning and hands-on execution while helping create the systems, processes, and alignment necessary for sustainable growth.

• Partner directly with the CEO on strategic initiatives and organizational priorities
• Drive execution of key business objectives across multiple functional areas
• Support company growth initiatives, operational planning, and scaling efforts
• Identify opportunities to improve efficiency, communication, and organizational effectiveness

• Prepare investor presentations, fundraising materials, and board reporting packages
• Assist with executive communications and strategic messaging
• Support leadership team planning, goal tracking, and accountability initiatives

• Coordinate high-priority projects across technical, operational, and commercial teams
• Ensure alignment and execution across multiple stakeholders and workstreams
• Remove roadblocks and drive projects from concept through completion

• Support strategic partnerships and enterprise customer relationships
• Assist in developing operational frameworks and scalable business processes
• Contribute to organizational planning and growth initiatives

• Partner with leadership on recruiting and talent acquisition efforts
• Help build and scale organizational infrastructure as the company grows
• Support initiatives that strengthen culture, communication, and team effectiveness

• Exceptional organizational and project management skills
• Strong executive communication and stakeholder management abilities
• Ability to operate effectively in ambiguous, fast-moving environments
• Highly proactive, resourceful, and execution-oriented mindset
• Comfortable balancing strategic thinking with hands-on execution
• Interest in emerging technologies, innovation, and high-growth environments

Experience in one or more of the following areas is highly valued:

• Startup or high-growth companies
• Management consulting
• Venture capital or private equity
• Healthcare, life sciences, or biotechnology
• Artificial Intelligence or technology organizations
• Business operations, strategy, or executive leadership support

This role offers a rare opportunity to work side-by-side with a founder and executive team, helping shape the future of a rapidly growing organization. For the right person, this is more than a Chief of Staff role, it's an opportunity to help build a company, influence key decisions, and create meaningful impact at a pivotal stage of growth.

Requirements

• 5+ years of relevant experience in Chief of Staff, operations, strategy & operations, business operations, or similar roles
• Prior experience working in a startup environment
• Experience owning and operating across hiring/recruiting, finance and budgeting, GTM and sales operations, and partnerships/vendor management
• Experience managing stakeholders including investors, board members, enterprise customers, clinical study partners, vendors, and internal team leads
• Authorized to work in the United States

• Bachelor's degree
• MBA

Benefits

• Comprehensive health insurance (medical, dental, vision)
• 401(k) retirement plan with company contribution
• Generous paid time off and holidays
• On-site office in Princeton, NJ with modern amenities
• Opportunities for rapid professional growth in a high-impact, scaling organization
• Collaborative, flat organizational culture with direct access to leadership
• Professional development and training support