ZipRecruiter

Log In

1

Bioinformatics Software Developer Jobs in California

Plasmidsaurus Inc

Bioinformatics Scientist

San Francisco, CA · On-site

$170K - $190K/yr

Position Overview You'll work on the bioinformatics engine powering that impact, wearing many hats ... Is curious about the intersection of biology, algorithms, and software engineering. * Gets excited ...

Roche

Sr. Manager, Bioinformatics

Santa Clara, CA · Hybrid

$170K - $316K/yr

You will lead an elite team of bioinformatics scientists and software engineers to create bespoke, high-impact solutions, resolve sophisticated technical roadblocks, and even engage in collaborative ...

Roche

Sr. Manager, Bioinformatics

San Diego, CA · Hybrid

$170K - $316K/yr

You will lead an elite team of bioinformatics scientists and software engineers to create bespoke, high-impact solutions, resolve sophisticated technical roadblocks, and even engage in collaborative ...

next page

Showing results 1-20

All JobsBioinformatics Software Developer JobsBioinformatics Software Developer Jobs in California

Bioinformatics Software Developer information

See California salary details

$5

$43

How much do bioinformatics software developer jobs pay per hour?

As of Jul 14, 2026, the average hourly pay for bioinformatics software developer in California is $42.23, according to ZipRecruiter salary data. Most workers in this role earn between $41.97 and $42.45 per hour, depending on experience, location, and employer.

What does a bioinformatics software developer do?

A bioinformatics software developer designs and implements software tools to analyze biological data, such as genetic sequences and molecular structures. They often use programming languages like Python or R, work with large datasets, and collaborate with scientists to create algorithms that support research and diagnostics.

What are some common challenges faced by Bioinformatics Software Developers in their daily work?

Bioinformatics Software Developers often work with large and complex biological datasets, which can present challenges in terms of data integration, processing efficiency, and scalability. Keeping up with rapidly evolving research methodologies and integrating new scientific findings into software solutions can also be demanding. Developers must collaborate closely with biologists, researchers, and other IT professionals to ensure that the tools they build meet scientific needs and are user-friendly. Strong problem-solving skills and adaptability help in overcoming technical and domain-specific obstacles, making this a dynamic and intellectually rewarding career choice.

What is a Bioinformatics Software Developer job?

A Bioinformatics Software Developer designs, implements, and optimizes software tools for analyzing biological data, such as genomic sequences or protein structures. They combine expertise in computer science, bioinformatics, and data science to develop algorithms, databases, and pipelines that support research and clinical applications. These developers often work with researchers to streamline data processing, improve efficiency, and enable new discoveries in the life sciences. Strong programming skills in languages like Python, Java, or R, along with knowledge of bioinformatics frameworks, are essential for this role.

What engineer makes $500,000 a year?

Highly experienced software engineers, especially those in specialized fields like machine learning, AI, or working at top tech companies, can earn $500,000 or more annually. These roles often require advanced skills, certifications, and a strong track record of innovation or leadership in the industry.

What is the salary of bioinformatic software developer?

The salary of a bioinformatics software developer typically ranges from $70,000 to $120,000 annually, depending on experience, education, location, and industry. Professionals with advanced skills in programming, data analysis, and familiarity with tools like Python, R, and Linux tend to earn higher salaries.

Is AI going to replace bioinformatics?

Bioinformatics software developers use AI and machine learning tools to analyze biological data, but AI is designed to augment rather than replace human expertise in interpreting complex biological information. AI can automate routine tasks and improve data analysis efficiency, but human oversight remains essential for developing algorithms, validating results, and making critical decisions in bioinformatics research.

What are the key skills and qualifications needed to thrive in the Bioinformatics Software Developer position, and why are they important?

To thrive as a Bioinformatics Software Developer, you need strong programming skills (especially in Python, R, or Java), a solid foundation in computational biology, and typically a degree in computer science, bioinformatics, or a related field. Familiarity with bioinformatics tools (such as BLAST, Bioconductor, or Galaxy), experience with version control systems like Git, and understanding databases and cloud platforms are commonly required. Collaboration, problem-solving abilities, and strong communication skills help facilitate effective teamwork across interdisciplinary scientific teams. These competencies are vital for developing robust software solutions that address complex biological data challenges encountered in research and healthcare settings.

What are popular job titles related to Bioinformatics Software Developer jobs in California? For Bioinformatics Software Developer jobs in California, the most frequently searched job titles are:
What job categories do people searching Bioinformatics Software Developer jobs in California look for? The top searched job categories for Bioinformatics Software Developer jobs in California are:
Bioinformatics Software Developer jobs near you
Infographic showing various Bioinformatics Software Developer job openings in California as of July 2026, with employment types broken down into 83% Full Time, 12% Part Time, 2% Temporary, 1% Contract, and 2% Nights. Highlights an 82% Physical, 2% Hybrid, and 16% Remote job distribution, with an average salary of $87,834 per year, or $42.2 per hour.
Staff Bioinformatics / Machine Learning Scientist

Staff Bioinformatics / Machine Learning Scientist

Exact Sciences

La Jolla, CA • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 3 days ago

Exact Sciences rating

8.5

Company rating: 8.5 out of 10

Based on 54 frontline employees who took The Breakroom Quiz

21st of 105 rated laboratories

Job description

Help us change lives
At Exact Sciences, we're helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you're working to help others.
Position Overview
Staff Bioinformatics and Machine Learning Scientist will lead the development and application of machine learning, statistical modeling, and bioinformatics for next-generation sequencing-based products. This individual will serve as a senior technical leader within Research and Development, working cross-functionally with bioinformatics, assay development, data engineering, software development, quality and product development teams.
The ideal candidate has deep experience analyzing large and complex biological datasets in an industry setting and has demonstrated successful development, validation and deployment of algorithms, statistical and machine learning models using principled and reproducible methodology.
This is a senior individual contributor role requiring strong scientific and technical leadership, and the ability to translate complex genomic data into insights and products.
Essential Duties
Include, but are not limited to, the following:
  • Lead the development, evaluation and optimization of machine learning and statistical models for high-dimensional NGS and genomics datasets.
  • Design and implement bioinformatics algorithms to support NGS assay development, analytical performance evaluation, quality control, signal detection, classification, or interpretation.
  • Collaborate with wet-lab scientists to design experiments, interpret results, identify technical issues, and recommend next steps.
  • Apply rigorous statistical and computational methods to evaluate assay performance, reproducibility, robustness, sensitivity, specificity, and sources of technical or biological variation.
  • Develop reproducible analysis workflows using modern bioinformatics, data science, and software engineering practices.
  • Work within cloud computing environments to process, analyze, and manage large-scale sequencing datasets.
  • Present and summarize complex technical findings effectively to cross-functional audiences.
  • Serve as subject matter expert for NGS bioinformatics, machine learning and statistical analysis.
  • Identify opportunities and build out proof of concept implementations for new state-of-the-art methodology across machine learning, bioinformatics and software engineering
  • Provide guidance and mentorship to junior team members.
  • Support development activities within a quality-managed or regulated environment.
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company's Quality Management System policies and procedures.
  • Maintain regular and reliable attendance.
  • Ability to act with an inclusion mindset and model these behaviors for the organization.
  • Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 90% of a typical working day.
  • Ability to work on a computer and phone simultaneously.
  • Ability to travel 10% of working time away from work location, may include overnight/weekend travel.

Minimum Qualifications
  • Ph.D. in bioinformatics, computational biology, computer science, mathematics, or related field; or Master's degree in bioinformatics, computational biology, computer science, mathematics, or related field plus 4 years of experience in lieu of a Ph.D.; or Bachelor's degree in bioinformatics, computational biology, computer science, mathematics, or related field plus 6 years of experience in lieu of Ph.D.
  • 8+ years of industry or academia experience in bioinformatics.
  • 6+ years of experience in medical device/IVD, biotech, life science or pharmaceutical industry.
  • Demonstrated experience in developing statistical and quantitative methods.
  • Deep knowledge and thorough understanding of molecular biology and/or biochemistry and/or next-generation sequencing (NGS) and genomics.
  • Demonstrated expertise in product/assay research, design, or development.
  • Basic computer skills to include Internet navigation, Email usage, and word processing. Proficient in Microsoft Office to include Excel, Word, and PowerPoint.
  • Demonstrated ability to perform the Essential Duties of the position with or without accommodation.

Preferred Qualifications
  • 10+ years of experience in medical device/IVD, biotech, life science or pharmaceutical industry.
  • Deep expertise in NGS bioinformatics and genomic data analysis.
  • Practical experience effectively leveraging AI in regulated environments
  • Experience with modern cloud-based MLOps systems
  • Experience developing and applying advanced linear and non-linear statistical learning methods on complex datasets, including but not limited to supervised and unsupervised machine learning techniques.
  • Familiarity with applying deep learning to high dimensional data.
  • Previous experience as a project lead for a team of scientists.
  • 2+ years of direct people leadership and management experience.
  • Experience in a pharmaceutical or biotech manufacturing environment, preferably in a GMP and/or ISO environment.
  • Previous industry experience in product development or technical support.
  • Previous experience working in molecular diagnostics.

#LI-CB1
Salary Range:
California Ranges: $154,400.00 - $231,600.00
The annual base salary shown is a national range for this position on a full-time basis and may differ by hiring location. In addition, this position is bonus eligible.
Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits.
Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here.
Not ready to apply? Join our Talent Community to stay updated on the latest news and opportunities at Exact Sciences.
We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to disability, protected veteran status, and any other status protected by applicable local, state, or federal law.
To view the Right to Work, E-Verify Employer, and Pay Transparency notices and Federal, Federal Contractor, and State employment law posters, visit our compliance hub. The documents summarize important details of the law and provide key points that you have a right to know.

What Exact Sciences employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom

Apply