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Director Bioinformatics Jobs in California (NOW HIRING)

Tempus AI, Inc.

Bioinformatics Scientist

Redwood City, CA · On-site

$100 - $175/hr

We are seeking a highly motivated and capable Bioinformatics Scientist to join our Liquid Biopsy ... Work closely with wet-lab assay development scientists, medical directors, clinical scientists ...

Tempus

Bioinformatics Scientist

Redwood City, CA · On-site

We are seeking a highly motivated and capable Bioinformatics Scientist to join our Liquid Biopsy ... Work closely with wet-lab assay development scientists, medical directors, clinical scientists ...

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All JobsBioinformatics JobsDirector Bioinformatics JobsDirector Bioinformatics Jobs in California

Director Bioinformatics information

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$28.6K

$104.2K

$172.2K

How much do director bioinformatics jobs pay per year?

As of Aug 26, 2026, the average yearly pay for director bioinformatics in California is $104,229.00, according to ZipRecruiter salary data. Most workers in this role earn between $72,000.00 and $128,800.00 per year, depending on experience, location, and employer.

What is a director bioinformatics?

A Director of Bioinformatics leads teams that analyze complex biological data using computational tools and techniques. They oversee the development of algorithms, manage bioinformatics projects, and collaborate with scientists to interpret genomic and molecular data. Their role involves strategic planning, managing research initiatives, and ensuring that bioinformatics solutions align with organizational goals. Typically, they work in biotech, pharmaceutical, or academic settings, driving innovation through data-driven insights. Strong leadership, expertise in bioinformatics tools, and an understanding of biology and programming are essential for this role.

What are the key skills and qualifications needed to thrive as a director bioinformatics?

To thrive as a Director of Bioinformatics, you need advanced expertise in computational biology, data analytics, genomics, and a graduate degree in bioinformatics, computational biology, or a related field. Proficiency with tools like Python, R, SQL, cloud-based platforms, and bioinformatics pipelines, as well as leadership certifications, is highly valued. Outstanding candidates possess strategic thinking, excellent communication, team leadership, and project management abilities. These skills are vital for leading multidisciplinary teams, driving cutting-edge research, and delivering actionable insights in fast-evolving scientific environments.

What are some typical challenges faced by a director bioinformatics, and how can they be addressed?

A Director of Bioinformatics often faces the challenge of managing large, complex datasets and integrating diverse types of biological data from multiple sources. Balancing the needs of scientific research teams with company or institutional goals requires strong leadership and strategic prioritization. Effective collaboration with scientists, clinicians, and IT staff is essential to ensure data accuracy, platform scalability, and actionable results. Staying updated with rapidly evolving bioinformatics tools and methodologies also presents a continuous learning opportunity. Proactively investing in team training, establishing robust data management practices, and fostering open communication can help address these challenges.

What are the most commonly searched types of Bioinformatics jobs in California?

The most popular types of Bioinformatics jobs in California are:

What are popular job titles related to Director Bioinformatics jobs in California?

For Director Bioinformatics jobs in California, the most frequently searched job titles are:

What job categories do people searching Director Bioinformatics jobs in California look for?

The top searched job categories for Director Bioinformatics jobs in California are:

What cities in California are hiring for Director Bioinformatics jobs?

Cities in California with the most Director Bioinformatics job openings:

Director Bioinformatics jobs near you
Infographic showing various Director Bioinformatics job openings in California as of August 2026, with employment types broken down into 2% As Needed, 85% Full Time, 10% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $104,229 per year, or $50.1 per hour.

Senior Director, Bioinformatics

Palo Alto, CA

Summit Therapeutics
See more jobs at Summit Therapeuticsexternal

Full-time

Posted 16 days ago

Job description

Overview of Role: 

The Senior Director of Bioinformatics will provide scientific, strategic, and operational leadership for bioinformatics and computational biology activities supporting discovery, translational research, clinical development, and biomarker programs. This individual will work with a multidisciplinary team responsible for the analysis and interpretation of genomic, transcriptomic, proteomic, spatial, pathology, imaging, molecular modeling and clinical datasets to enable target identification, patient stratification, biomarker discovery, companion diagnostic development, and data-driven decision-making across the company's pipeline. 

The successful candidate will serve as a key partner to Translational Medicine/Research, Biomarkers and Clinical Development teams and will help shape the organization's long-term data and computational strategy. 

Role and Responsibilities: 

Translational Research and Biomarker Development 

  • Lead analyses supporting biomarker discovery, patient selection, pharmacodynamic assessments, and mechanisms of response and resistance. 
  • Direct integration of multiomic datasets including:  
  • Whole exome sequencing (WES) 
  • Whole genome sequencing (WGS) 
  • RNA sequencing 
  • Single-cell sequencing 
  • Spatial transcriptomics 
  • Proteomics 
  • ctDNA 
  • Digital pathology and imaging data 
  • Collaborate with translational scientists and clinicians to generate biologically meaningful insights that influence clinical development strategy. 
  • Support companion diagnostic (CDx) development and regulatory submissions. 
  • Molecular modeling of protein-protein interactions 

Strategic Leadership 

  • Develop and execute the company's bioinformatics and computational biology strategy across discovery, translational, and clinical programs. 
  • Interface with high-performing team of biochemists, computational biologists, and data scientists. 
  • Establish scientific priorities, resource plans, and technology roadmaps aligned with corporate objectives. 
  • Evaluate emerging technologies in AI/ML, multiomics, digital pathology, spatial biology, and real-world data analytics. 

Data Science and AI 

  • Drive implementation of machine learning and AI-based approaches for biomarker identification and predictive modeling. 
  • Establish computational methods for integrating molecular and clinical data. 
  • Partner with digital pathology and imaging teams on AI-enabled analyses. 
  • Evaluate and implement cloud-based analytics platforms and scalable computational infrastructure. 

Scientific Collaboration 

  • Partner closely with:  
  • Discovery Research 
  • Translational Medicine 
  • Clinical Development 
  • Biostatistics 
  • Companion Diagnostics 
  • Manage external collaborations with academic institutions, CROs, technology providers, and diagnostic partners. 

Operational Excellence 

  • Establish best practices for data governance, reproducibility, quality control, and regulatory compliance. 
  • Oversee bioinformatics infrastructure, cloud computing resources, and data management processes. 
  • Ensure timely delivery of analyses supporting key development milestones. 
  • All other duties as assigned 

 
Experience, Education and Specialized Knowledge and Skills: 

  • PhD in Bioinformatics, Computational Biology, Genetics, Genomics, Computer Science, Statistics, Systems Biology, or related field. 
  • Minimum of 15+ years of relevant experience in biotechnology, pharmaceutical, diagnostics, or related industries. 
  • Strong track record supporting oncology, inflammation, or other therapeutic development programs. 
  • Experience with biomarker strategies across multiple stages of drug development. 
  • Experience supporting IND, BLA, NDA, PMA, or companion diagnostic submissions preferred. 
  • Demonstrated expertise in: 
  • NGS analysis pipelines 
  • Multiomics data integration 
  • Statistical genomics 
  • Clinical biomarker analysis 
  • Single-cell and spatial biology analytics 
  • Machine learning and predictive modeling 
  • Cloud computing platforms (AWS, Azure, GCP) 
  • Programming languages such as R and Python 
  • Data visualization and scientific communication 
  • Preferred Qualifications 
  • Oncology drug development experience strongly preferred. 
  • Experience supporting companion diagnostic development and precision medicine strategies. 
  • Understanding of FDA, EMA, and global regulatory expectations for biomarker data. 
  • Experience with AI-powered pathology platforms and image analysis. 
  • History of scientific publications in high-impact journals. 
  • Experience working in cross-functional teams in a matrixed environment. 

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