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Biohub Jobs in California (NOW HIRING)

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies. Our Vision * We pursue large ...

Research Engineer, AI

Redwood City, CA · Hybrid

$214K - $375K/yr

Biohub operates one of the largest AI compute clusters dedicated to biology, spanning three frontier research institutes with some of the world's leading biologists. We're not a startup trying to ...

Research Engineer, AI

Redwood City, CA · On-site +1

$214K - $375K/yr

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Research Scientist, AI

Redwood City, CA · On-site +1

$214K - $375K/yr

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Research Scientist, AI

Redwood City, CA · Hybrid

$214K - $375K/yr

Biohub operates one of the largest AI compute clusters dedicated to biology, spanning three frontier research institutes with some of the world's leading biologists. We're not a startup trying to ...

Staff AI Infrastructure Engineer

Redwood City, CA · On-site +1

$131K - $172K/yr

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Lab Manager

Redwood City, CA · On-site

$106K - $133K/yr

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

The Opportunity CZ Biohub's mission is to cure or prevent all human disease. Achieving that requires training frontier-scale AI biology models, and that demands reliable, high-performance compute ...

Collaborate closely with scientists across Biohub to build safeguards that are robust to potential misuse, enabling our AI systems to be used for maximum societal benefit . * Gain direct access to a ...

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate ...

Lab Manager

Redwood City, CA · On-site

$106K - $133K/yr

Laboratory Operations is central to the research conducted at the Biohub, and we're looking for someone who is inspired to contribute to our mission. What You'll Do * Oversee and perform daily wet ...

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Biohub information

See California salary details

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How much do biohub jobs pay per hour?

As of Sep 8, 2026, the average hourly pay for biohub in California is $25.79, according to ZipRecruiter salary data. Most workers in this role earn between $14.83 and $30.13 per hour, depending on experience, location, and employer.

What is a Biohub?

A Biohub job typically refers to a role within a collaborative research institute that brings together scientists, engineers, and technologists to advance biomedical innovation. These jobs can span various disciplines, including biology, data science, and engineering, with a focus on accelerating discoveries in health and disease. Biohubs often foster interdisciplinary teamwork and use cutting-edge technologies to solve complex medical challenges.

What kinds of teams or professionals do Biohub employees typically collaborate with?

Biohub employees often work closely with a diverse range of professionals, including scientists, engineers, bioinformaticians, and clinical researchers. Collaboration is central to the role, as projects frequently involve cross-functional teams working together to solve complex biological problems and develop new technologies. Employees can expect regular meetings, interdisciplinary brainstorming sessions, and shared laboratory or research resources. This collaborative environment not only accelerates scientific discovery but also offers significant opportunities for professional learning and networking.

What are the key skills and qualifications needed to thrive in the Biohub position, and why are they important?

To excel in a Biohub position, strong expertise in biomedical research, molecular biology, and data analysis is typically required, often supported by an advanced degree in life sciences or related fields. Familiarity with high-throughput screening technologies, laboratory information management systems (LIMS), and specialized lab equipment is highly valued. Excellent collaboration, adaptability, and strong communication skills are crucial for thriving in fast-paced, multidisciplinary teams. These capabilities are vital for driving innovative research and ensuring the successful execution of cutting-edge bioscience projects.

What are popular job titles related to Biohub jobs in California?

For Biohub jobs in California, the most frequently searched job titles are:

What cities in California are hiring for Biohub jobs?

Cities in California with the most Biohub job openings:

Infographic showing various Biohub job openings in California as of August 2026, with employment types broken down into 100% Full Time. Highlights an 50% Physical, 4% Hybrid, and 46% Remote job distribution, with an average salary of $53,653 per year, or $25.8 per hour.

Scientist II, Scaling Lead

Biohub

San Francisco, CA • On-site

Full-time

Retirement, PTO

Posted 11 days ago


Job description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
  • We pursue large scientific challenges that cannot be pursued in conventional environments
  • We enable individual investigators to pursue their riskiest and most innovative ideas
  • The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
    Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

This position will work with the team of Dr. Loic Royer to build instruments, AI, and molecular tools to understand how cells self-organize to build, maintain, and repair tissues. The team designs and operates state-of-the-art light-sheet microscopes (including the DaXi platform), develops the Ultrack cell-tracking framework, and produces the Zebrahub atlas of vertebrate development.
The Opportunity
Biohub is seeking a Scientist II to lead the scaling of our imaging and data-generation pipeline. This role will set throughput targets, find the bottlenecks that matter most, and work hands-on with the sample-prep, imaging, and computation teams to remove them - at the bench, at the microscope, and at the keyboard.
We are looking for someone who is curious, dependable, and excited to work at the interface of biology, imaging technology, and collaborative platform science. The ideal candidate is proactive, learns quickly, communicates well across teams, and enjoys contributing to both established workflows and the development of new experimental approaches across a wide range of disciplines, from optics, microscopy, and image processing to developmental, cell, and molecular biology.
This position is well-suited for candidates who have already built a live-imaging pipeline in a developing organism from the ground up - instrument, reporter lines, sample handling, acquisition, and analysis - and are excited to take on the challenge of scaling that pipeline. The strongest candidates will have hands-on experience in microscope design, sample preparation, model-organism husbandry, imaging, and quantitative analysis, with a track record of making methods more robust and reproducible.
What You'll Do
  • Map the full sample-to-data pipeline, define quantitative throughput and quality targets, instrument each stage with metrics and dashboards, and maintain a living view of the true bottlenecks - so effort is always spent on the binding constraint.
  • Spend significant hands-on time alongside sample-prep, imaging, and computational scientists, diagnosing and fixing the concrete obstacles - protocol, hardware, software, or logistics - that limit data generation on any given week.
  • Increase the number of specimens prepared and imaged per session and reduce variability across the sample-handling workflow - staging, mounting, and quality control - in partnership with the Bioengineering and Zebrafish Transgenesis platforms.
  • Improve multi-specimen acquisition, instrument uptime, and cross-instrument reproducibility on the group's light-sheet microscopes, pushing sustained throughput toward the platform's practical limits.
  • Work with the computation team to keep the image-processing pipeline (denoising, registration, fusion, deconvolution, segmentation, tracking) keeping pace with acquisition, addressing I/O, compute throughput, storage, and data retention so that raw acquisitions become analysis-ready results without a growing backlog.
  • Establish reproducible SOPs, QC gates, and monitoring to ensure improvements persist as the team, instruments, and datasets scale - and to measure throughput, not assume it.
  • Serve as the connective tissue between the group and Biohub's shared platforms, removing cross-team bottlenecks and helping the group hit its shared throughput milestones.
  • Mentor and technically guide team members, translate scaling strategy into concrete engineering and experimental plans, and help recruit as the effort grows.
  • Document architectures, protocols, release methods, code, and data for the community, in keeping with Biohub's open-science ethos.
What You'll Bring
Essentials
  • Ph.D. plus postdoctoral experience in physics, biophysics, optics/photonics, bioengineering, or a related quantitative discipline, with a body of work developing and applying advanced live-imaging methods.
  • 5 years of proven experience of end-to-end ownership of a live-imaging pipeline in a developing organism - personally carrying a project from instrument and transgenic reporter lines through sample preparation, acquisition, and image analysis to quantitative, model-ready results. This is the single most important qualification for the role.
  • Hands-on design and construction of light-sheet (or comparable custom optical) microscopes - building, aligning, and maintaining instruments, not only operating them.
  • Direct experience imaging live embryos or other living specimens over extended time-lapse - ideally zebrafish - including sample preparation, mounting, and the husbandry that sustains long acquisitions.
  • Experience developing and working with transgenic reporter lines for live imaging.
  • Strong quantitative image processing and analysis, with scientific software development in Python - including building reusable, shareable analysis tools (e.g., segmentation, tracking, or spatial/neighborhood analysis).
  • Quantitative or physical-biology modeling that connects measurements to theory.
  • A demonstrated commitment to robustness, reproducibility, and scalability - a track record of making instruments or methods simpler, more reliable, more automated, or higher-throughput.
  • Systems thinking and hands-on, collaborative leadership - the ability to reason across optics, biology, and computation, locate the binding constraint, and work directly with colleagues to remove it; excellent written and oral communication; and a genuine commitment to interdisciplinary, open science.

Nice to have
  • Prior collaboration with the Royer Group, or familiarity with its instrument and software ecosystem (DaXi light-sheet, Ultrack, Zebrahub).
  • Experience quantifying fast transcriptional or signaling dynamics in living organisms, particularly in oscillatory systems such as the segmentation clock.
  • Authorship of open-source scientific software adopted beyond your own lab.
  • Fluorescent-protein, photoconvertible, or biosensor engineering.
  • Experience in increasing the throughput of acquisition or sample handling through automation (e.g., liquid handling or robotic sample handling).
  • Familiarity with high-performance / GPU computing and large-scale data and storage pipelines.
  • Experience with advanced or multimodal light-sheet imaging techniques.
  • A record of cross-institutional, multidisciplinary collaboration spanning optics, molecular biology, and computation.
Compensation
The San Francisco, CA base pay range for a new hire in this role is $138,000 - $172,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Benefits for the Whole You
We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
  • Provides a generous employer match on employee 401(k) contributions to support planning for the future.
  • Paid time off to volunteer at an organization of your choice.
  • Funding for select family-forming benefits.
  • Relocation support for employees who need assistance moving

If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
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