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Position Title: Scientist

Location: On-Site/Philadelphia, PA

Reports to: Jinmin Lee

Department: Cellular Immunology Preclinical

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio's headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients' own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We're proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work

About the Position:

Please provide a summary of the Position:

We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro, ex vivo, and in vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.

Responsibilities:

• Conduct hands-on laboratory experiments following established protocols to maintain and expand, bank, and manage various cell lines and generate CAR T cells.
• Perform and validate cytotoxicity and flow cytometry assays.
• Perform and validate ELISpot, ELISA, Luminex, MSD, or other assays as needed.
• Perform lab associated tasks in accordance with Cabaletta Bio lab safety policies and SOPs.
• Oversee in vivo mouse studies and perform related ex vivo assays as needed.
• Ensure proper maintenance and cleanliness of laboratory equipment and workspaces.
• Maintain accurate and well-organized records and electronic laboratory notebook.
• Analyze experimental data using basic statistical methods and software tools.
• Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions.
• Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.

Required Qualifications:

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0-2 years, or Master's degree with a minimum of 5 years, or Bachelor's degree with minimum of 10 years of experience.
• Hands-on experience with cell culture and basic molecular biology techniques.
• General lab skills, including aseptic techniques and human tissue handling required.
• Must have prior experience and be highly skilled at mammalian cell culture (aseptic techniques).
• Experience in primary cell husbandry, cytotoxicity assays, and flow cytometry.
• Prior involvement in animal studies or hands-on animal handling advantageous.
• Must be highly organized and able to work independently.
• A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise. 
• Strong team orientation and passion for continuous self-development.
• Strong organizational skills, attention to detail, and the ability to follow protocols accurately.
• Effective written and verbal communication skills to share experimental findings and collaborate with team members.

Preferred Qualifications:

• Extensive hands-on experience with primary immune cell cultures and assays advantageous.
• Experience working in a research or industry setting related to immunology and/or cell therapy.
• Experience in industry or in a startup industrial setting.
• Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.

Our name - Cabaletta - is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit  https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

#LI-ONSITE