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Associate Scientist Process Chemistry Jobs in Wisconsin

CYNET SYSTEMS

Associate Scientist I

Madison, WI · On-site

$28/hr

... of chemistry, six semester hours of biology, and 12 semester hours of chemistry, biology, or ... Manage daily test processing needs along with project needs in a high quality, efficient and ...

CYNET SYSTEMS

Associate Scientist I

Madison, WI · On-site

$30/hr

... of chemistry, six semester hours of biology, and 12 semester hours of chemistry, biology, or ... Manage daily test processing needs along with project needs in a high quality, efficient and ...

CYNET SYSTEMS

Associate Scientist I

Madison, WI · On-site

$29/hr

... of chemistry, six semester hours of biology, and 12 semester hours of chemistry, biology, or ... Manage daily test processing needs along with project needs in a high quality, efficient and ...

CYNET SYSTEMS

Associate Scientist I

Madison, WI · On-site

$31/hr

... of chemistry, six semester hours of biology, and 12 semester hours of chemistry, biology, or ... Manage daily test processing needs along with project needs in a high quality, efficient and ...

CYNET SYSTEMS

Associate Scientist I

Madison, WI · On-site

$22 - $27/hr

The Clinical Laboratory Scientist I duties include, but are not limited to, processing of specimens ... of chemistry, six semester hours of biology, and 12 semester hours of chemistry, biology, or ...

Eurofins

Associate Scientist I

River Falls, WI · On-site

Knowledge and ability to conduct specific processes related to testing in Agrigenomics lab that may ... An Associate Scientist must also have a working knowledge of Microsoft Office and the ability to ...

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All JobsAssociate Scientist Process Chemistry JobsAssociate Scientist Process Chemistry Jobs in Wisconsin

Associate Scientist Process Chemistry information

What is the difference between Associate Scientist Process Chemistry vs Associate Scientist Formulation?

AspectAssociate Scientist Process ChemistryAssociate Scientist Formulation
Required CredentialsBachelor's or Master's in Chemistry, Chemical Engineering, or related fieldBachelor's or Master's in Chemistry, Pharmaceutical Sciences, or related field
Work EnvironmentLaboratories focused on chemical reactions, process development, and scale-upLaboratories and manufacturing settings focused on drug formulation and stability testing
Employer & Industry UsagePharmaceutical, biotech, chemical manufacturing companiesPharmaceutical, biotech, and contract manufacturing organizations

Associate Scientist Process Chemistry and Associate Scientist Formulation roles share similar educational backgrounds and work environments within the pharmaceutical industry. However, Process Chemistry focuses on developing and optimizing chemical processes, while Formulation concentrates on creating and testing drug formulations. Both roles are essential in drug development and often overlap in industry usage.

What are the most commonly searched types of Scientist Process Chemistry jobs in Wisconsin? The most popular types of Scientist Process Chemistry jobs in Wisconsin are:
What are popular job titles related to Associate Scientist Process Chemistry jobs in Wisconsin? For Associate Scientist Process Chemistry jobs in Wisconsin, the most frequently searched job titles are:
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What cities in Wisconsin are hiring for Associate Scientist Process Chemistry jobs? Cities in Wisconsin with the most Associate Scientist Process Chemistry job openings:
Associate Scientist Process Chemistry jobs near you

Scientist III, Process Chemistry (Antibody-siRNA Conjugates)

Arrowhead Pharmaceuticals

Madison, WI • On-site

$110K - $125K/yr

Full-time

Re-posted 14 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a motivated Scientist III to join our Process Chemistry team, focused on the development and scale-up of conjugated RNAi therapeutics. This role centers on process development for antibody-siRNA conjugates (AOCs/ARCs), a key expansion of Arrowhead's TRiM platform into targeted extrahepatic delivery. The successful candidate will span the full development continuum - taking discovery-stage conjugation protocols, optimizing them for robustness and reproducibility, and developing them into GMP, kilogram-scale manufacturing processes. This is a hands-on role at the bench combined with oversight of external CRO/CDMO partners.

Responsibilities

  • Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
  • Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
  • Work hands-on in the laboratory to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
  • Oversee and direct CROs/CDMOs executing process development and manufacturing activities, including setting technical direction, reviewing data, and ensuring timelines and quality standards are met.
  • Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using relevant analytical methods (e.g., HIC, SEC, IEX, LC-MS, AEX).
  • Lead technology transfer to internal and external manufacturing partners, authoring process descriptions, batch records, and development reports.
  • Troubleshoot process and analytical challenges; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
  • Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams

Requirements

  • PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or a related field; or a Bachelor's/Master's degree with commensurate hands-on industry experience.
  • Demonstrated hands-on experience in siRNA conjugation development is required.
  • Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
  • Familiarity with purification and analytical characterization of conjugates.
  • Strong problem-solving, documentation, and communication skills.

Preferred

  • Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
  • Experience developing and scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
  • Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
  • Experience with tech transfer and CMC/GMP environments.
Wisconsin pay range
$110,000—$125,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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