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Associate Downstream Processing Scientist Jobs in Raleigh, NC

KBI Biopharma, Inc.

Senior Director, MS&T

Durham, NC · On-site

... Scientists and will collaborate with Process Development, Quality, Supply Chain, Facilities ... Must have demonstrated biologics expertise in upstream or downstream processing and operations Must ...

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All JobsAssociate Downstream Processing Scientist JobsAssociate Downstream Processing Scientist Jobs in Raleigh, NC

Associate Downstream Processing Scientist information

See Raleigh, NC salary details

$18

$34

$55

How much do associate downstream processing scientist jobs pay per hour?

As of Sep 14, 2026, the average hourly pay for associate downstream processing scientist in Raleigh, NC is $34.92, according to ZipRecruiter salary data. Most workers in this role earn between $27.12 and $39.71 per hour, depending on experience, location, and employer.

What is the difference between Associate Downstream Processing Scientist vs Associate Upstream Processing Scientist?

AspectAssociate Downstream Processing ScientistAssociate Upstream Processing Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Skills & CertificationsProtein purification, chromatography, GMP complianceCell culture, bioreactor operation, aseptic techniques
Work EnvironmentLaboratories, manufacturing facilitiesBioreactors, cell culture labs
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical research and production

Both roles are essential in biopharmaceutical production, with the Associate Downstream Processing Scientist focusing on purification processes, while the Associate Upstream Processing Scientist handles cell growth and fermentation. They often collaborate within the same production pipeline, but their skill sets and daily tasks differ based on their specific focus areas.

What are popular job titles related to Associate Downstream Processing Scientist jobs in Raleigh, NC?

For Associate Downstream Processing Scientist jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Associate Downstream Processing Scientist jobs in Raleigh, NC look for?

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Associate Downstream Processing Scientist jobs near you
Infographic showing various Associate Downstream Processing Scientist job openings in Raleigh, NC as of September 2026, with employment types broken down into 1% As Needed, 71% Full Time, 25% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 96% Physical, 1% Hybrid, and 3% Remote job distribution, with an average salary of $72,637 per year, or $34.9 per hour.

Downstream Manufacturing Specialist

Morrisville, NC • On-site

Astrix Inc
Recruiting and Staffing Services • 1 - 5K employees
Learn more about Astrix Incexternal

$40 - $42/hr

Contractor, Other

Posted 19 days ago

Key responsibilities

  • Execute downstream manufacturing activities for gene therapy products in accordance with approved batch records, SOPs, protocols, and GMP requirements.

  • Perform and support downstream purification and processing operations, including clarification, filtration, centrifugation, chromatography, TFF, buffer and media preparation, ultrafiltration/diafiltration, product concentration and formulation, aseptic processing, and final bulk operations.

  • Operate, clean, sanitize, and maintain manufacturing equipment and associated systems, and document manufacturing activities accurately in batch records, logbooks, and electronic systems.

Job description

Pay Rate Low: 40 | Pay Rate High: 42
We are seeking a Downstream Manufacturing Specialist to support the manufacturing of gene therapy products in a GMP-regulated environment. This role will be responsible for executing and supporting downstream purification and processing activities, ensuring manufacturing operations are performed safely, efficiently, and in accordance with approved procedures and regulatory requirements.
The ideal candidate has hands-on experience with downstream bioprocessing, strong attention to detail, and a working knowledge of GMP manufacturing practices. This is a contract-to-hire opportunity for an individual who is interested in building a long-term career within a growing gene therapy organization.
Pay rate: $40-42/hr
Shift: 1st shift, with occasional 2nd shift
Key Responsibilities
  • Execute downstream manufacturing activities for gene therapy products in accordance with approved batch records, SOPs, protocols, and GMP requirements.
  • Perform and support downstream purification and processing operations, which may include:
    • Clarification and filtration
    • Centrifugation
    • Chromatography
    • Tangential flow filtration (TFF)
    • Buffer and media preparation
    • Ultrafiltration/diafiltration
    • Product concentration and formulation
    • Aseptic processing and final bulk operations
  • Operate, clean, sanitize, and maintain manufacturing equipment and associated systems.
  • Perform in-process sampling and coordinate with Quality Control for testing as required.
  • Accurately document manufacturing activities in batch records, logbooks, and electronic systems in accordance with Good Documentation Practices (GDP).
  • Identify process deviations, equipment issues, and manufacturing abnormalities and promptly escalate them to appropriate personnel.
  • Support deviation investigations, CAPAs, change controls, and other manufacturing quality initiatives.
  • Follow all applicable GMP, environmental health and safety (EHS), biosafety, and facility procedures.
  • Assist with equipment setup, line clearance, cleaning verification, and manufacturing area preparation.
  • Participate in process optimization, continuous improvement, and manufacturing scale-up activities.
  • Work closely with Manufacturing, Process Development, Quality Assurance, Quality Control, Engineering, and Facilities teams.
  • Support technology transfer and process validation activities as needed.
  • Maintain a clean, organized, and compliant manufacturing environment.
  • Participate in shift activities, overtime, and occasional weekend work based on manufacturing schedules.

Qualifications
Required
  • Bachelor's degree in Biology, Biochemistry, Chemical Engineering, Biotechnology, or a related scientific/engineering discipline, or equivalent relevant experience.
  • 2+ years of experience in biopharmaceutical, biologics, cell therapy, gene therapy, or related GMP manufacturing.
  • Hands-on experience with downstream bioprocessing and purification operations.
  • Understanding of GMP manufacturing principles and Good Documentation Practices.
  • Ability to follow detailed SOPs and batch records while maintaining a high level of accuracy.
  • Strong communication, organizational, and problem-solving skills.
  • Ability to work effectively in a cross-functional, team-oriented environment.
  • Ability to work on-site in a manufacturing environment and wear required PPE.

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