ZipRecruiter

Log In

1

Associate Downstream Process Development Scientist Jobs in Malvern, PA

CEDENT

Process Scientist

Philadelphia, PA

... developed process to GMP manufacturing. A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical ...

next page

Showing results 1-20

All JobsAssociate Downstream Process Development Scientist JobsAssociate Downstream Process Development Scientist Jobs in Malvern, PA

Associate Downstream Process Development Scientist information

See Malvern, PA salary details

$18

$33

$48

How much do associate downstream process development scientist jobs pay per hour?

As of Sep 12, 2026, the average hourly pay for associate downstream process development scientist in Malvern, PA is $33.05, according to ZipRecruiter salary data. Most workers in this role earn between $27.12 and $40.58 per hour, depending on experience, location, and employer.

What is an associate downstream process development scientist?

An Associate Downstream Process Development Scientist is a professional who works in the biotechnology or pharmaceutical industry, focusing on developing and optimizing processes that purify biological products, such as proteins or antibodies, after they have been produced by cells. Their work is crucial for ensuring the final product meets quality and safety standards before it is used in research or clinical applications. They typically perform laboratory experiments, analyze data, and collaborate with other scientists and engineers to improve yield and efficiency. This role is often entry-level or early-career, providing hands-on experience in process development and technical troubleshooting.

What are some typical challenges faced by an associate downstream process development scientist, and how can they be addressed?

Associate Downstream Process Development Scientists often encounter challenges such as optimizing purification processes, troubleshooting equipment performance, and ensuring batch-to-batch consistency. These challenges can be addressed by maintaining meticulous documentation, collaborating closely with upstream and analytical teams, and staying current with best practices in chromatography and filtration. Proactively seeking feedback from experienced colleagues and participating in cross-functional meetings can also help in identifying solutions and improving process efficiency.

What are the key skills and qualifications needed to thrive as an associate downstream process development scientist, and why are they important?

To excel as an Associate Downstream Process Development Scientist, you need a solid understanding of biochemistry, chemical engineering, and downstream purification techniques, often supported by a bachelor's or master's degree in a life science or engineering discipline. Familiarity with chromatographic systems (such as AKTA), filtration equipment, and analytical tools, as well as knowledge of GMP/GLP regulations, is typically required. Strong problem-solving, attention to detail, and effective teamwork and communication skills help you navigate complex experiments and collaborate with cross-functional teams. These skills ensure efficient process optimization, compliance with regulatory standards, and successful development of biopharmaceutical products.

What is the difference between Associate Downstream Process Development Scientist vs Associate Upstream Process Development Scientist?

AspectAssociate Downstream Process Development ScientistAssociate Upstream Process Development Scientist
Primary FocusPurification and recovery of bioproductsCell culture and fermentation processes
Required SkillsProtein purification, chromatography, filtrationCell culture, bioreactor operation, media preparation
Work EnvironmentLaboratories, manufacturing facilitiesLaboratories, bioreactor labs
Common CertificationsBiotech or bioprocessing certificationsBiotech or bioprocessing certifications

Both roles are essential in biopharmaceutical development, focusing on different stages of the production process. The Associate Downstream Process Development Scientist specializes in purification techniques, while the Associate Upstream Process Development Scientist concentrates on cell growth and fermentation. Understanding these distinctions helps candidates target their skills and career paths effectively.

What cities near Malvern, PA are hiring for Associate Downstream Process Development Scientist jobs?

Cities near Malvern, PA with the most Associate Downstream Process Development Scientist job openings:

Associate Downstream Process Development Scientist jobs near you

Scientist - Lentiviral Vector Downstream Process Development

Spring House, PA • On-site

Jj
See more jobs at Jjexternal

Full-time

Posted 22 days ago

Key responsibilities

  • Design and execute downstream process development studies for lentiviral therapeutic products.

  • Conduct purification experiments including chromatography, filtration, UF/DF, and formulation, and automated high-throughput systems.

  • Support technology transfer to Johnson & Johnson's manufacturing sites and collaborate on process development and process optimization.

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more atjnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Scientist - Lentiviral Vector Downstream Process Development to be based in Spring House, PA.

Purpose:

The Scientist, Lentiviral Vector Downstream Process Development, will lead development, optimization, and characterization of scalable purification processes for cell therapy and CAR-T programs. This role will contribute to early- or clinical-stage process development, with emphasis on purification process strategy at varying scales and data-driven process understanding, platform knowledge and robustness, and optimization of downstream process technologies. This role will also support technology transfer to Johnson & Johnson's manufacturing sites, commercial manufacturing investigations and provide subject matter expert knowledge as part of life cycle management for cell therapy products in Johnson & Johnson's pipeline.

You will be responsible for:

  • Design and execute downstream process development studies for lentiviral therapeutic products under scientific guidance

  • Conduct purification experiments including chromatography, filtration, UF/DF, and formulation, and automated high-throughput systems

  • Contribute todevelopmentof lentiviral processes to continuously improve productivity, quality, and manufacturability.

  • Oversee operation and management of downstream equipment, including AKTA systems, TFF systems, and purification skids.

  • Perform technology transfer to and collaborate with Johnson & Johnson's manufacturing sites

  • Support existing and new commercial manufacturing investigations and provide subject matter expert knowledge as part of product life cycle management

  • Apply statistical experimental design, data analytics, and online monitoring and visualization tools to strengthen downstream process understanding.

  • Analyze and interpret process data using JMP,MiniTab, Python, Spotfire, or similar platforms.

  • Evaluate emerging novel downstream technologies that improve process robustness and development efficiency.

  • Collaborate closely with upstream, analytical, formulation, modeling, automation to align study design and deliverables

  • Author technical reports, development summaries, scientific presentations, protocols, and regulatory-supporting documentation.

Qualifications:

Required:

  • BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2-4 years of relevant industry experience; OR

  • Experience with process development of viral based products.

  • Experience in purification process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.

  • Hands-on experience with chromatography, clarification, depth filtration, UF/DF, sterile filtration, and process scale-up.

  • Strong data analysis, experimental design, and technical documentation skills.

  • Excellent written and verbal communication skills.

  • Ability to work effectively in cross-functional team environments.

  • Previous experience with technology transfer of a bioprocess to clinical or commercial GMP manufacturing is strongly preferred

  • Occasional weekend work may be required

  • Up to 10% domestic and international travel may be required

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

Required Skills:

Preferred Skills:

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Collaboration, Conducting Experiments, Data Quality, Drug Discovery Development, Molecular Diagnostics, Patent Applications, Pharmacogenetics, Report Writing, Research Documents, Scientific Research, Technologically Savvy, Written Expression

Apply