Associate Downstream Process Development Scientist Jobs in Colorado

Agilent inspires and supports discoveries that advance the quality of life. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables,applicationsandexpertise. Agilent enables customers to gain the answers and insights theyseek ---- so they can do what they do best: improve the world around us. Information about Agilent is available atwww.agilent.com.

Wantto take your knowledge and experience further? Ready to provide technical leadership and make key decisions? This is your opportunity - not only to join a committed, professional, and forward-thinking team but also to lead in the design and implementation of complex manufacturing processes and transform broad concepts into structured results-focused projects.

Join a growing team with this exciting new opportunity for an expert levelDownstreamProcess Engineer.Work onadynamic, fast-paced,large capacity oligonucleotide API production facilitydesign andconstructionproject.Contribute to the growing industry of oligonucleotide (DNA-RNA) based therapeutics.

Responsibilities may include but are not limited to:

• Technicalleadfor downstream processes and unit operations.Responsible for process modeling andconsulted on process fit and throughput assessments.

• Responsible for process design review for large capital projects, includinguserrequirements specifications development,P&IDs, layouts, and equipment selection.

• Responsible for equipment design and procurement support, includingequipment and instrumentation specification/selection, equipment procurement,FAT/SAT,installation, commissioning, qualification, andturn-overto manufacturing.

• Consulted on Automation/Controlsdesign, including instrumentationselection, equipment interface, and equipment module / phase design.

• SupportChemical Development inthe development,characterization, and scaleupof innovative Oligonucleotide production processes and technologies.

• Responsible for Building Information Model (BIM)review forprocess piping and equipment,cleanroom design,andgeneralspatial planning to achievemanufacturing requirements.

• Responsible forplanning,review, and execution ofprocess startup, commissioning, and qualification activities.

• Consultedonproject management aspects including project schedule, budget, and coordination of multi-disciplinary teams.

• Support EHS activities including PHA, PSSR, and PSM compliance.

REQUIRED:

Bachelor's orMaster's Degree in Chemical Engineeringor equivalent education/experience.

8+ years of combined experience in pharma/biopharma and fine chemicals industryto includeexperience with P&IDs, facility layouts, mass and energy balances, solvent handling, equipmentdesign, user requirement specifications (URS).

6+ years ofexperience with medium tolarge-sized projects through all phases, including design, design review, process hazard analysis, equipment procurement, installation, commissioning, and qualification.

DESIRED:

Familiarity with current ASME BPE sanitary piping and equipment design standards, electrical standards such as National Fire Protection Association / National Electrical Code (NFPA 70 / NEC), and International Fire and Building Code

Experience with Oligonucleotidemanufacturingdownstreamunit operations and processesincluding:

Column packing,preparativeliquidchromatography,bufferpreparation,reaction,ultrafiltration, evaporation, drying.

Experience with design of industrial control systems, including SCADA, PLCs, and BAS, and validation documentation, including installation, operational, and performance qualification (IQ/OQ/PQ) protocols.

Experienceand familiaritywithOSHA Process Safety Management (PSM) program requirements.

Engineering, communication, and organizational skills to support the safe, efficient, and compliantdesign, construction, and startup of an APImanufacturing facility.

Self-motivated, hands-on problem solver with the ability to work within multi-disciplinary teams, including process development, manufacturing, validation, quality, safety, and project management personnel.