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Analytical Method Development Jobs (NOW HIRING)

Living Proof Inc

Analytical Chemist

Boston, MA

$100K - $120K/yr

Responsibilities include analytical method development and validation, investigating complex analytical problems, supporting quality activities, and contributing to product claims substantiation. The ...

Granules

Scientist I, AR&D

Chantilly, VA · On-site

This includes performing the Assay Dissolution, analytical method development, and method validation including preparing analytical method validation and verification protocols . Additionally, you ...

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How much do analytical method development jobs pay per year?

As of May 31, 2026, the average yearly pay for analytical method development in the United States is $191,412.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,000.00 and $249,000.00 per year, depending on experience, location, and employer.

What is an Analytical Method Development job?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What are the key skills and qualifications needed to thrive in the Analytical Method Development position, and why are they important?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

What does a typical day look like for someone working in Analytical Method Development?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.
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Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in the United States as of May 2026, with employment types broken down into 95% Full Time, and 5% Part Time. Highlights an 70% Physical, 4% Hybrid, and 26% Remote job distribution, with an average salary of $191,412 per year, or $92 per hour.
Scientist II/Sr. Scientist I, Analytical Research and Development

Scientist II/Sr. Scientist I, Analytical Research and Development

Beam Therapeutics

Cambridge, MA

Other

Posted 23 days ago

Job description

Position Overview

We are seeking a Scientist II/ Senior Scientist I with handson experience in phaseappropriate analytical method development, optimization, qualification, and transfer to support the release, stability, and characterization of cell and gene therapy products. This role will mainly support Beam's in vivo lipid nanoparticle (LNP) based programs and will be based in a laboratory environment.

The ideal candidate will have experience in design and development of analytical methods for mRNA, gRNA, protein, protein conjugate, lipid, and LNP, experience working collaboratively with cross-functional research and CMC teams, and have a working knowledge of analytical ICH/USP guidelines.

Primary Responsibilities:

  • Lead early through late phase method development, optimization, and transfer for lot release, stability, and characterization of drug substances, critical materials, and drug products.
  • Establish technical leadership as subject matter expert in multiple analytical techniques during method development and transfer and provide technical troubleshooting support when needed.
  • Work with cross-functional groups including Research & Development, Quality Control, and Process Development teams to participate in various aspects of method development, transfer, characterization, comparability, and investigation.
  • Coordinate routine sample testing including requests from Research and Development groups and Process Development teams.
  • Author and review SOPs, technical reports, and assist in the preparation of CMC regulatory submissions.
  • Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance.
  • Maintaining detailed documentation of experiments in ELN system.
  • Adapting to a fast-paced, dynamic research environment.
  • Mentor and train junior scientists
  • Living Beam Therapeutics core values of being part of a community of fearless innovators, being rigorous and honest in our research, listening with open minds, and committed to each other.

Qualifications:

  • Degree in a relevant discipline (biochemistry, biotechnology, biological sciences, bioengineering, or related fields). Minimum PhD with 2+ years or BS/MS with 10-15 years (title based on experience) industry experience including biotech, biopharma, CRO, and CDMO.
  • Must have hand on experience on analytical method development, optimization, qualification, and testing at GMP or non-GMP environments, supporting clinical phase programs.
  • Experience with analysis of RNAs, proteins, protein conjugates, lipids, and lipid nanoparticles (LNPs) is highly desirable and will be key to success in this role.
  • Extensive experience with at least one or several of the analytical techniques is required: HPLC (RP, IPRP, SEC, IEX), capillary gel electrophoresis, ELISA. Experience with qPCR, DNA and RNA extraction, western blotting, UV spectrophotometry, DLS, MALS, mass spectrometry, and compendial testing will be a plus.
  • Experience with analytical CMC development, method transfer, and QC technical support is highly desirable.
  • A good understanding of ICH Q2 and Q14, with working knowledge on analytical Quality by Design concept.
  • CMC project management and people management experience will be a plus.
  • Familiarity with data analysis software such as Openlab, Chromeleon, and statistical software such as JMP.
  • Team player with excellent oral and written communication skills.
  • Independently motivated, detail-oriented scientist with excellent critical thinking and problem-solving abilities.
  • Excellent organizational skills towards multi-tasking in an extremely fast-paced environment with changing priorities.
  • Must be able to work onsite daily

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