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The TerraPower Isotopes (TPI) division has been established to pursue medical isotopes development--advancing nuclear science for significant human health benefits. We seek to support revolutionary radiotherapies for treatments of various cancers through the supply of radioisotopes. TerraPower currently has unique access to a supply of thorium for the long-term production of actinium-225 in the growing alpha therapy market and intends to expand into other nuclear related medical treatments.

The TerraPower Isotopes program is an integral part of the Washington State based TerraPower team, a company working to raise living standards globally. In 2006, the company originated with Bill Gates and a group of like-minded visionaries who evaluated the fundamental challenges to raising living standards around the world. TerraPower's mission is to be a world leader in new nuclear technologies, while developing innovators and future leaders in the nuclear field.

TPI is seeking to hire highly motivated and forward-thinking professionals who are interested in focusing on advanced radiopharmaceutical applications and influencing change within nuclear medicine. TerraPower is an Equal Opportunity Employer. We do not discriminate in hiring on the basis of sex, gender identity, sexual orientation, race, color, religious creed, national origin, physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. 

TPI Radioisotopes Manufacturing Program Manager

TerraPower Isotopes is seeking a Radioisotopes Manufacturing Program Manager to lead all aspects of actinium 225 manufacturing as an API starting material precursor for targeted radiopharmaceutical therapies. This role provides full operational leadership for day to day production activities in GMP aligned hot cell and glovebox operations, ensuring safe, compliant, and efficient manufacturing performance.

The ideal candidate brings strong technical acumen, sound judgment, and proven leadership in regulated nuclear, radiopharmaceutical, or chemical manufacturing environments. Success in this role requires effective communication, cross functional collaboration, and a commitment to operational excellence, radiological safety, and product quality.

Responsibilities

     Operational Leadership

• Own end to end manufacturing performance, including production planning, throughput, yield, and resource allocation.
• Lead day to day operations within hot cell and glovebox environments while ensuring compliance with all GMP, radiological, and safety requirements.
• Oversee execution, review, and continuous improvement of production processes, batch documentation, and data integrity practices.
• Drive troubleshooting and technical issue resolution in coordination with radiochemists, engineers, radiation safety, quality, and industrial safety.
• Ensure operations comply with FDA expectations for API starting material production, NRC and DOT radioactive material requirements, and applicable state and OSHA regulations.
• Partner closely with Quality on deviations, CAPAs, nonconformances, change controls, and internal/external audits.
• Maintain validated processes and equipment, ensuring changes follow approved validation and change control pathways.

     Cross Functional Coordination

• Coordinate with the Everett Laboratory (EVL) Manager to align manufacturing needs with other project and facility activities.
• Work with Maintenance Engineering and Facility Maintenance to plan outages, maintain equipment readiness, and support maintenance activities.
• Collaborate with Logistics to maintain adequate inventories of consumables, chemicals, and production-support materials.
• Partner with Radiation Safety and Health Physics to manage radiological work planning, radioactive materials inventory, contamination control, and waste handling.

 Key Qualifications and Skills

• Bachelor's degree in chemical engineering, radiochemistry, pharmaceutical sciences, or related laboratory or engineering discipline.
• Minimum 8 years of experience working with radioactive materials under an established radiation protection program; alphaemitter experience preferred.
• Leadership or supervisory experience in a regulated manufacturing environment (radiopharmaceutical, nuclear pharmacy, GMP chemical manufacturing, or comparable field) preferred.
• Strong working knowledge of FDA regulations for pharmaceutical/API starting materials, NRC and DOT regulations for radioactive materials, and applicable state health and OSHA requirements.
• Demonstrated ability to lead technical teams, manage priorities, and coordinate crossfunctional work in a highhazard environment.
• Effective written and verbal communication skills in English.
• Military experience is a plus.

Job Functions:

Job Functions are physical actions and/or working conditions associated with the position. These functions may also constitute essential functions for the job which the employee must be able to fulfill, with or without accommodation.  Information provided below is to help describe the job so that the applicant has a reasonable understanding of the job duties/expectations.  An applicant's ability to perform and/or tolerate these actions and conditions will be discussed and workplace accommodations may be made on a case-by-case basis following an individualized assessment of the applicant and other considerations, including but not limited to any governing safety standards.

• Motor Abilities: Sitting for extended periods, bending/stooping, grasping/gripping, fine motor control (hands)
• Physical exertion and/or requirements: Minimal, with ability to safely lift up to 25 pounds.
• Repetitive work: Prolonged
• Special Senses: Visual and audio focused work
• Work Conditions: Stairs, typing/keyboard, standard and/or sitting working environment of >8 hours/day
• Travel required 0-10%

TerraPower Isotopes' technology is controlled for export by various agencies of the U.S. Government.  TerraPower Isotopes must evaluate applicants who are foreign nationals (other than asylees, refugees, or lawful permanent residents) in accordance with U.S. Government export control requirements.  To facilitate TerraPower's export control reviews, you will be asked as part of the application process to identify whether you are a U.S. Citizen or national, asylee, refugee, or lawful permanent resident of the United States.  Government export authorization approval times vary.  Based on the business needs for a particular position, TerraPower Isotopes may not consider a foreign national from a country if it is impracticable to obtain timely Government export approval.

Job details

Salary Range: $168,316 - $252,475 

*We typically place offers in the lower to middle portion of the range to maintain internal equity and allow room for growth. Any salary offered within the posted salary band is based on market data and commensurate with the selected individual's qualifications experience.  This range is specific to Washington State.

Benefits:

• Competitive Compensation
• Salary, eligible to participate in discretionary short-term incentive payments
• Comprehensive Medical and Wellness Benefits
  •   Medical
  •   Vision
  • Dental
  • Life and Disability
  • Gender Affirmation Benefits
• Parental Leave
• 401k Plan
• Generous Paid Time Off (PTO)
  • 21 days of annually accrued PTO
• Generous Holiday Schedule
  • 10 paid holidays
• Relocation Assistance
• Professional and Educational Support Opportunities

TerraPower Career and Benefits information: https://www.terrapower.com/careers/