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58 Bighat Jobs Hiring Near You

BigHat

Principal, Machine Learning Scientist

San Mateo, CA · On-site

$254 - $290/hr

At BigHat Biosciences our full-stack antibody drug development platform uses ML to drive every stage from discovery to optimization. Our roboticized high-throughput wet-lab continually adds to our ...

BigHat

Scientist II, Developability

San Mateo, CA · On-site

$145 - $165/hr

San Mateo, CA Description BigHat Biosciences is looking for a hands‑on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed ...

BigHat

Automation Engineer II

San Mateo, CA · On-site

$140 - $168/hr

BigHat Biosciences is seeking a hands‑on Automation Engineer to build, support, and sustain the automated workflows that power our high‑throughput antibody production and characterization ...

New

BigHat

$140 - $168/hr

BigHat Biosciences is seeking a hands‑on Automation Engineer to build, support, and sustain the automated workflows that power our high‑throughput antibody production and characterization ...

New

BigHat Biosciences

Automation Engineer II

San Mateo, CA · On-site

$150K - $168K/yr

BigHat Biosciences is seeking a hands-on Automation Engineer to build, support, and sustain the automated workflows that power our high-throughput antibody production and characterization platform.

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Senior Scientist II, Biomolecular Characterization

BigHat

San Mateo, CA • On-site

$145 - $165/hr

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Posted yesterday

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Job description

Scientist II, Biomolecular Characterization

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA


Description

The role: BigHat Biosciences is seeking an exceptional individual for a Scientist II or Senior Scientist I in Biomolecular Characterization* role to drive characterization of in vitro antibody-target binding behavior, develop new assay capabilities, and represent the team across BigHat’s programs.

*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.


Key Responsibilities
  • Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
  • Implement best practices for binding assay design across various bioanalytical assay formats.
  • Troubleshoot and diagnose assay issues, building foundational understanding of antibody/antigen interactions that stakeholders can act on.
  • Collaborate closely with BigHat’s science organization to accelerate hits from discovery through lead optimization and candidate nomination.
  • Effectively synthesize and communicate results and research activity to key decision makers and the broader BigHat team.
  • Partner with automation engineering, software engineering, and production teams to scale and productionize high-throughput kinetics assays.

Skills Knowledge and Expertise
  • Ph.D. 2-5 years, or M.Sc with 5+ years of independent research and development experience in an industry setting, including substantial experience with binding assays including BLI, SPR, ELISA/MSD and Flow Cytometry workflows (preferably across Carterra, Cytiva and Sartorius instrumentation).
  • Practical and theoretical fluency in bioanalytical science, biochemistry, biophysics, assay design and development (experience in both complex and buffered matrices preferred).
  • Experience with lab automation and working with automation engineers (preferred).
  • Strong data analysis and interpretation skills coupled to exceptional written, verbal, and visual communication skills.
  • Ability to educate and build consensus among diverse stakeholders regarding scientific direction.

Total Rewards

The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

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