Vaxcyte
Vaxcyte

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Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health ...

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Infographic showing various job openings at Vaxcyte in the United States as of August 2026, with employment types broken down into 98% Full Time, and 2% Part Time. Highlights an 73% Physical, 8% Hybrid, and 19% Remote job distribution.

Engineer II, Conjugation Development and Manufacturing

Vaxcyte

San Carlos, CA • On-site

$146K - $171K/yr

Full-time

Re-posted 2 days ago


Job description

Summary:

Vaxcyte is seeking a highly motivated and technically proficient Engineer II to join the Conjugation Process Development and Manufacturing group within the CMC organization. This individual will contribute to the development, scale up, and manufacturing of Vaxcyte's multi valent polysaccharide based conjugate vaccines, which leverage a novel carrier protein produced through cell free synthesis. Conjugation-the covalent linkage of polysaccharide antigens to carrier proteins-is a critical component of Vaxcyte's vaccine platform, and this role will support both laboratory development and cGMP manufacturing activities.

The successful candidate will bring hands on laboratory experience, a solid understanding of bioprocess operations, and practical exposure to cGMP environments, ideally within late-stage development. This position requires close collaboration with cross functional CMC teams, active participation in production campaigns, and the ability to independently execute development experiments and document technical findings. The role offers a unique opportunity to contribute directly to the advancement of Vaxcyte's vaccine programs while developing deep expertise in conjugation process development and manufacturing.

Essential Functions:
  • Operation and maintenance of laboratory equipment, including chemical reactors, TFF systems, HPLCs, and plate readers.
  • Support the design and execution of development studies to optimize and characterize conjugation processes.
  • Provide technical oversight during cGMP production campaigns, including preparation, on floor support, troubleshooting, deviation assessment, and change control execution.
  • Review executed protocols and batch records for accuracy, completeness, and compliance.
  • Serve as a subject matter expert for conjugation related activities on project teams.
  • Contribute to facility and equipment design considerations to support process scale up and manufacturing readiness.
  • Participate in the development of conjugation processes for pipeline programs.
  • Maintain accurate and complete documentation in laboratory notebooks or electronic systems.
  • Engage in technical discussions and contribute to data interpretation and decision making.
  • Collaborate effectively within a team environment to support departmental and program objectives.
Requirements: 
  • PhD with 2-5, MS with minimum of 7, BS/BA with minimum of 10 years of experience in Chemical Engineering, Biochemical Engineering, Chemistry, Biology, or a related discipline
  • Practical experience with bioprocess operations at bench, pilot, or manufacturing scale.
  • Strong working knowledge of cGMP principles and their application in bioprocess environments.
  • Foundational understanding of engineering principles relevant to bioprocess development and scale up.
  • Proficiency with standard software tools, including Excel, Word, PowerPoint, Visio, and JMP.
  • Demonstrated ability to work in cross functional teams and manage multiple concurrent activities.
  • Excellent written and verbal communication skills.
Reports to: Staff Engineer, Conjugation Development and Manufacturing
 
Location: San Carlos, CA
 
Work Arrangement: Onsite 5 days per week
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $146,000 - $171,000 (SF Bay Area). Salary ranges for non-California locations may vary.

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About Vaxcyte

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

San Carlos, CA, US

Year founded

2013