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33 Substack Data Scientist Jobs Hiring Near You

Navan

Economist

San Francisco, CA

As part of our broader Data Science and Analytics function, you will... * Perform complex ... Substack or X. * A collaborative and approachable style, with a proven ability to build ...

Navan

Economist

San Francisco, CA · On-site

$172K - $265K/yr

As part of our broader Data Science and Analytics function, you will... * Perform complex ... Substack or X. * A collaborative and approachable style, with a proven ability to build ...

Navan

Economist

San Francisco, CA · On-site

Required : • 5-7 years experience with an advanced degree in Economics, Statistics, Data Science ... Substack or X. Company : Navan provides travel, expense, and corporate card management to automate ...

Higher People

Software Engineer

San Francisco, CA · On-site

$150K - $300K/yr

We're trusted by teams like ClickUp, Substack, and Alloy, and backed by top-tier investors ... data sources that we do not yet support. Is this you? * Strong fundamentals in computer science

a16z

Editorial Intern, Crypto

... our website, newsletter on Substack, videos on YouTube, and more. The team is composed of ... Help produce special series and projects, from data reports to op-eds to other media packages

Artie Technologies Inc

Product Engineer

San Francisco, CA · On-site

$150K - $215K/yr

We make high-volume data replication simple, reliable, and scalable for engineering teams. Our ... We're trusted by teams like ClickUp, Substack, and Alloy, and backed by top-tier investors ...

a16z

OR

... our website, newsletter on Substack, videos on YouTube, and more. The team is composed of ... Help produce special series and projects, from data reports to op-eds to other media packages

Modal

Forward Deployed Engineer - Systems

New York, NY · On-site

The FDE team today includes world-class software engineers, computational scientists, ML engineers ... Familiarity with distributed systems architecture, data pipelines, and Infrastructure as Code ...

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Infographic showing various Data Scientist job openings at Substack in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 55% Physical, and 45% Remote job distribution.

Machine Learning Scientist

Variational AI

Vancouver, BC • Remote

Full-time

Posted 25 days ago

Job description

Salary: $150K-200K Annually Compensation varies by experience, skills and location

VANCOUVER, BC (OR REMOTE*) / 2+ YRS PROFESSIONAL EXPERIENCE


Small molecule drug discovery is one of the most exciting open problems in machine learning. Traditional approaches require over ten years and two billion dollars to develop a new pharmaceutical, and their reliance on trial-and-error calls out for better predictive and generative models. The existent datasets are large enough to benefit from sophisticated deep learning architectures, but small enough that ML models can be trained in a few days, facilitating rapid experimentation and innovation. Nevertheless, the current industry standard has progressed little beyond shallow ML techniques such as random forests and support vector machines, largely due to the difficulty of integrating world-class machine learning research with chemistry and pharmacology expertise.


Variational AI is searching for a machine learning scientist to join us in our quest to radically accelerate the development of new drugs through machine learning excellence. For over six years, we have beenadvancing the state-of-the-art, and delivering projects to customers including Merck, Rakovina Therapeutics, and ImmVue Therapeutics.


You will help design, implement, test, and refine novel elements of a machine learning architecture built from the ground up to optimize the properties of small molecule drugs; continually improve the robustness of our existing code base; and apply our pipeline to new drug targets. Experience developing novel ML algorithms in domains such as diffusion models, Transformers, graph neural networks, uncertainty quantification, and Bayesian optimization is required, but we can provide all necessary background in chemistry, pharmacology, and biology.


Here is the background were looking for:

  • Ph.D. in CS, applied mathematics, statistics, physics, or related discipline;
  • Expertise with machine learning techniques, including diffusion models, Transformers, and Bayesian optimization, demonstrated through first-author publications in conferences like NeurIPS, ICLR, and ICML;
  • Two or more years experience developing robust code on larger projects, including code review, refactoring, unit testing, version control, etc.;
  • Mastery of Python and PyTorch; and
  • Intellectual curiosity and drive to excel.


We are an equal opportunity employer and enthusiastically welcome applications from women, BIPOC, and members of underrepresented communities and groups. Compensation is a competitive mix of cash and options. We prioritize expertise and passion over where you decide to live and work; however, for collaboration across our team, applicants must be based in *North American time zones.


To learn more about us, you can find some of our recent work at variationalai.substack.com