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Weekend Science Jobs in California (NOW HIRING)

Adidev Technologies Inc

Data Science

San Francisco, CA · On-site

As a Data Scientist/Data Science Specialist for Adidev Technologies Inc., you will be enhancing and debugging large-scale applications for one of our well-known clients. Adidev Technologies is a ...

Adidev Technologies Inc

Data Science

San Francisco, CA · Remote

As a Data Scientist/Data Science Specialist for Adidev Technologies Inc., you will be enhancing and debugging large-scale applications for one of our well-known clients. Adidev Technologies is a ...

Adidev Technologies Inc

Data Science

San Francisco, CA · On-site

$110 - $170/hr

As a Data Scientist/Data Science Specialist for Adidev Technologies Inc., you will be enhancing and debugging large-scale applications for one of our well-known clients. Adidev Technologies is a ...

Mad Science

STEM Birthday/Event Performer

Hayward, CA · On-site

$50/hr

Must be available evenings and weekends * Knowledge of basic science (don't worry - we'll train the rest!) * Lots of ENERGY * All employees will be fingerprinted for criminal background check and TB ...

Mad Science

STEM Birthday/Event Performer

Burlingame, CA · On-site

$50/hr

Must be available evenings and weekends * Knowledge of basic science (don't worry - we'll train the rest!) * Lots of ENERGY * All employees will be fingerprinted for criminal background check and TB ...

Mad Science

STEM Birthday/Event Performer

Fremont, CA · On-site

$50/hr

Must be available evenings and weekends * Knowledge of basic science (don't worry - we'll train the rest!) * Lots of ENERGY * All employees will be fingerprinted for criminal background check and TB ...

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Weekend Science information

See California salary details

$28.1K

$54.5K

$89.8K

How much do weekend science jobs pay per year?

As of Sep 5, 2026, the average yearly pay for weekend science in California is $54,465.00, according to ZipRecruiter salary data. Most workers in this role earn between $41,000.00 and $64,100.00 per year, depending on experience, location, and employer.

What is a Weekend Science?

A Weekend Science job typically involves scientific research, laboratory work, or technical support that takes place on weekends. These roles are common in industries like healthcare, research institutions, and environmental monitoring, where experiments or operations continue beyond standard work hours. Responsibilities may include conducting experiments, analyzing data, maintaining equipment, or assisting with ongoing projects. Weekend Science jobs can be ideal for students, part-time workers, or professionals looking to supplement their income while contributing to scientific advancements.

What are the typical responsibilities and work schedules for someone in a Weekend Science position?

Weekend Science professionals are often responsible for conducting experiments, recording data, and maintaining laboratory equipment during weekend shifts. Schedules usually involve working part-time on Saturdays and Sundays, often as part of a rotating team to ensure research continuity. You may collaborate closely with weekday staff through detailed handover notes, so clear communication and documentation are important. This setup allows for extended research hours, supporting projects that require ongoing monitoring or time-sensitive work, and can be ideal for students or those seeking flexible employment in the sciences.

What are the key skills and qualifications needed to thrive in the Weekend Science position, and why are they important?

To excel in a Weekend Science role, candidates typically need a strong background in biological, chemical, or physical sciences, often supported by a relevant degree or laboratory experience. Familiarity with laboratory equipment, data analysis software, and common safety protocols is essential. Strong attention to detail, communication, and problem-solving skills are important soft skills for this position. These abilities ensure safe, efficient, and accurate completion of experiments and collaboration within the team during weekend shifts.

What are some fun weekend science jobs?

Weekend science jobs include roles such as science camp instructors, museum educators, or event demonstrators, which often involve engaging the public with hands-on experiments. These positions typically require strong communication skills, basic scientific knowledge, and sometimes certifications like CPR or safety training. They offer flexible schedules and opportunities to share science in informal settings.

What job should I get if I like science?

If you like science, you can pursue roles such as a laboratory technician, research scientist, or science teacher. These jobs often require strong knowledge of scientific principles, relevant degrees, and sometimes certifications or laboratory skills. They typically involve working in labs, educational settings, or research environments.

What are the most commonly searched types of Science jobs in California?

The most popular types of Science jobs in California are:

What cities in California are hiring for Weekend Science jobs?

Cities in California with the most Weekend Science job openings:

Weekend Science jobs near you
Infographic showing various Weekend Science job openings in California as of August 2026, with employment types broken down into 1% As Needed, 71% Full Time, 24% Part Time, and 4% Contract. Highlights an 74% Physical, 3% Hybrid, and 23% Remote job distribution, with an average salary of $54,465 per year, or $26.2 per hour.

Scientist / Sr Scientist

Aragen Life Sciences

Morgan Hill, CA • On-site

$130K - $175K/yr

Full-time

Posted 8 days ago

Job description

About Aragen Bioscience
Aragen Bioscience is a leading contract research organization (CRO) dedicated to accelerating biologics discovery and development. Our capabilities span antibody discovery, protein engineering, cell line development, process development, and analytical characterization. We partner with emerging biotechnology companies and global pharmaceutical organizations to advance innovative therapies from concept to clinic.
We are seeking a highly motivated Scientist/Senior Scientist, Protein Sciences & Biologics Development to lead client programs, mentor scientific staff, and drive the development of next-generation biologic therapeutics. This is a hands-on scientific leadership role combining technical excellence, client engagement, and people leadership in a fast-paced CRO environment.
Position Summary
The Senior Scientist will serve as a technical lead for client-sponsored biologics programs, overseeing activities from molecular design and protein engineering through expression, purification, characterization, and technology transfer. The successful candidate will provide scientific leadership to project teams, contribute to business growth through exceptional client delivery, and coach junior scientists while maintaining hands-on laboratory involvement.
This position requires extensive experience in protein sciences, molecular biology, protein engineering, and downstream process development, together with a demonstrated ability to lead multiple client programs simultaneously. Due to the time-sensitive nature of projects and critical experimental workflows, occasional evening and weekend work may be required.
Key Responsibilities
Scientific Leadership & Client Delivery
  • Lead and manage client-sponsored biologics development programs from concept through deliverable completion.
  • Serve as the primary scientific contact for assigned clients, providing technical guidance, project updates, risk assessment, and strategic recommendations.
  • Present scientific data, project milestones, and development strategies to internal and external stakeholders.
  • Mentor and develop scientists, research associates, and junior team members through technical coaching and career development support.
  • Drive project execution to ensure delivery of high-quality data packages, reports, and client deliverables within established timelines.
  • Author and review technical reports, SOPs, study protocols, technical transfer documentation, and regulatory-supporting data packages.
  • Collaborate with multidisciplinary teams to resolve complex scientific and operational challenges.
  • Contribute to department innovation, workflow improvements, and scientific best practices.
Biologics Discovery & Molecular Biology
  • Design and optimize expression constructs and mammalian expression vectors for recombinant protein production.
  • Utilize AI-enabled and computational tools to support protein engineering, sequence optimization, structural prediction, and developability assessments.
  • Perform and oversee molecular biology workflows including:
    • Gibson Assembly
    • Restriction enzyme cloning
    • Site-directed mutagenesis
    • Plasmid characterization
    • Sequence verification
  • Lead RNA and DNA analytical workflows, including qPCR and RT-qPCR applications.
  • Apply bioinformatics tools for sequence analysis, codon optimization, construct design, and genetic engineering strategies.
Protein Engineering & Developability
  • Lead protein engineering, sequence optimization, and developability assessments for therapeutic proteins.
  • Evaluate protein stability, aggregation propensity, solubility, manufacturability, and biophysical properties.
  • Support antibody engineering, Mult specific formats, fusion proteins, cytokines, protein scaffolds, and other next-generation biologic modalities.
  • Collaborate with clients to develop strategies for candidate optimization and risk mitigation.
Protein Expression & Purification
  • Design, execute, and optimize recombinant protein expression workflows.
  • Lead hands-on downstream purification activities utilizing automated FPLC systems such as ÄKTA Avant and ÄKTA Pure.
  • Develop and optimize purification processes using:
    • Affinity Chromatography
    • Ion Exchange Chromatography (IEX)
    • Size Exclusion Chromatography (SEC)
    • Hydrophobic Interaction Chromatography (HIC)
  • Support process development and scale-up activities including:
    • Depth filtration
    • Tangential Flow Filtration (TFF)
    • Ultrafiltration/Diafiltration (UF/DF)
  • Troubleshoot complex purification and expression challenges independently.

Requirements
Required Qualifications
Education & Experience
  • Ph.D. in Molecular Biology, Biochemistry, Protein Engineering, Biotechnology, Chemical Engineering, or a related scientific discipline with 7+ years of relevant industry experience, OR
  • M.S. in a related scientific discipline with 12+ years of relevant industry experience.
  • Demonstrated experience in a CRO, biotechnology, or pharmaceutical environment.
  • Proven track record of leading external client projects and delivering successful outcomes.
  • Minimum 2 years of direct people leadership, mentoring, or supervisory experience.
Technical Expertise
  • Strong expertise in molecular biology, cloning technologies, vector design, and recombinant protein expression.
  • Extensive experience in protein engineering, developability assessment, and sequence optimization.
  • Deep hands-on experience in downstream process development and protein purification using FPLC systems.
  • Strong understanding of protein characterization, stability, aggregation, and formulation considerations.
  • Familiarity with computational biology, structural modeling, or AI-enabled protein engineering tools.
  • Experience with electronic laboratory notebooks (ELNs), scientific data analysis, and laboratory automation platforms.
Leadership & Professional Skills
  • Exceptional written and verbal communication skills.
  • Strong client-facing presentation and relationship management capabilities.
  • Ability to manage multiple complex projects simultaneously in a deadline-driven environment.
  • Demonstrated strategic thinking, scientific problem-solving, and decision-making skills.
  • Strong mentoring, coaching, and team-development abilities.
Preferred Qualifications
  • Experience with antibody engineering, Mult specific antibodies, fusion proteins, cytokines, and alternative protein scaffolds.
  • Experience supporting technology transfer and manufacturing scale-up activities.
  • Familiarity with GMP environments and regulatory expectations.
  • Experience implementing AI-enabled scientific workflows for protein design and development.
Why Join Aragen?
  • Work with cutting-edge biologics programs across diverse therapeutic modalities.
  • Collaborate with innovative biotech startups and leading global pharmaceutical companies.
  • Shape the scientific direction of client programs while mentoring the next generation of scientists.
  • Join a collaborative and entrepreneurial environment focused on scientific excellence and client success.

Aragen Bioscience is an Equal Opportunity Employer.
Salary Description
130,000 to 175,000 (Depending on experience)

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