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Weekend Infusion Rn Jobs in Saint Louis, MO (NOW HIRING)

LUX Infusion

Home Infusion Nurse

Saint Louis, MO · On-site

$36 - $47.75/hr

We're looking for a Per Diem Home Infusion Registered Nurse who wants their work to mean something - someone who brings clinical skill, compassion, and accountability to every patient interaction.

LUX Infusion

Home Infusion Nurse

Saint Louis, MO · On-site

$36 - $47.75/hr

We're looking for a Per Diem Home Infusion Registered Nurse who wants their work to mean something - someone who brings clinical skill, compassion, and accountability to every patient interaction.

LUX Infusion

Home Infusion Nurse

Saint Louis, MO

$45 - $60/hr

We're looking for a Per Diem Home Infusion Registered Nurse who wants their work to mean something -- someone who brings clinical skill, compassion, and accountability to every patient interaction.

ATULO HEALTH INC

PRN Home Infusion RN

Edwardsville, IL · On-site

Home Infusion RN - Per Diem Company: Atulo Health About Atulo Health: Atulo Health is a multi-state provider of home infusion services. We deliver high-quality, patient-centered care using smart ...

ATULO HEALTH INC

PRN Home Infusion RN

Belleville, IL · On-site

Home Infusion RN - Per Diem Company: Atulo Health About Atulo Health: Atulo Health is a multi-state provider of home infusion services. We deliver high-quality, patient-centered care using smart ...

ATULO HEALTH INC

PRN Home Infusion RN

Belleville, IL · On-site

Home Infusion RN - Per Diem Company: Atulo Health About Atulo Health: Atulo Health is a multi-state provider of home infusion services. We deliver high-quality, patient-centered care using smart ...

TNAA TotalMed RN

Travel Oncology RN

Saint Louis, MO · On-site

$2.0K - $2.8K/wk

Travel As an RN Infusion/PICC Nurse, you will provide specialized nursing care to patients requiring infusion therapy and/or PICC line management. With a focus on patient safety, comfort, and ...

TNAA TotalMed RN

Travel Oncology RN

Saint Louis, MO · On-site

$2.0K - $2.8K/wk

Travel As an RN Infusion/PICC Nurse, you will provide specialized nursing care to patients requiring infusion therapy and/or PICC line management. With a focus on patient safety, comfort, and ...

LUX Infusion

Home Infusion Nurse

Saint Louis, MO · On-site

$45 - $60/hr

We're looking for a Per Diem Home Infusion Registered Nurse who wants their work to mean something - someone who brings clinical skill, compassion, and accountability to every patient interaction.

LUX Infusion

Home Infusion Nurse

Saint Louis, MO · On-site

$45 - $60/hr

We're looking for a Per Diem Home Infusion Registered Nurse who wants their work to mean something - someone who brings clinical skill, compassion, and accountability to every patient interaction.

LUX Infusion

Infusion Nurse

Saint Louis, MO · On-site

$36 - $47.75/hr

We're looking for an Infusion Suite Nurse who wants their work to mean something - a licensed Registered Nurse who brings clinical excellence, empathy, and purpose to every patient interaction. Why ...

LUX Infusion

Ambulatory Infusion Clinic Nurse

Saint Louis, MO · On-site

$36 - $47.75/hr

We're seeking an experienced Infusion Nurse (RN) to support patients in an infusion suite and other care settings as needed. This is a Part-time role. Schedule and location may vary based on business ...

LUX Infusion

Infusion Nurse

Saint Louis, MO · On-site

$48 - $55/hr

We're looking for an Infusion Suite Nurse who wants their work to mean something - a licensed Registered Nurse who brings clinical excellence, empathy, and purpose to every patient interaction. Why ...

LUX Infusion

Infusion Nurse

Saint Louis, MO

$48 - $55/hr

We're looking for an Infusion Suite Nurse who wants their work to mean something -- a licensed Registered Nurse who brings clinical excellence, empathy, and purpose to every patient interaction. Why ...

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All JobsInfusion Rn JobsWeekend Infusion Rn JobsWeekend Infusion Rn Jobs in Saint Louis, MO

Weekend Infusion Rn information

See Saint Louis, MO salary details

$11

$44

$80

How much do weekend infusion rn jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for weekend infusion rn in Saint Louis, MO is $44.69, according to ZipRecruiter salary data. Most workers in this role earn between $35.29 and $48.85 per hour, depending on experience, location, and employer.

What is a Weekend Infusion RN?

A Weekend Infusion RN is a registered nurse who administers intravenous (IV) therapies, medications, and treatments to patients during weekends. They work in outpatient clinics, hospitals, or home health settings, ensuring safe and effective infusion therapy. Responsibilities include monitoring patients for reactions, maintaining IV access, and educating patients about their treatments. This role requires strong IV skills, attention to detail, and the ability to work independently. It is ideal for nurses seeking flexible weekend hours while providing critical care to patients requiring infusion services.

What are the typical responsibilities and work environment for a Weekend Infusion RN?

As a Weekend Infusion RN, you will primarily administer intravenous medications, monitor patients for side effects, and educate them about their treatment plans—often in outpatient clinics, specialty centers, or sometimes patients' homes. The work environment is usually focused and patient-centered, with collaboration between RNs, pharmacists, and physicians, especially for complex cases. Since the role is concentrated on weekends, you may work more independently and manage a smaller, more specialized patient load. This schedule offers flexibility and the opportunity to focus on building relationships with patients receiving ongoing infusion therapy.

What are the key skills and qualifications needed to thrive in the Weekend Infusion RN position, and why are they important?

Weekend Infusion RNs require a current RN license, strong IV therapy skills, and experience in administering infusion medications safely. Familiarity with infusion pumps, electronic health records (EHR), and up-to-date certifications like Basic Life Support (BLS) or Advanced Cardiac Life Support (ACLS) are typically expected. Excellent organizational skills, compassionate bedside manner, and the ability to work independently are valuable soft skills in this setting. Mastery of these competencies ensures reliable, high-quality patient care during weekends when resources may be limited.

Do infusion nurses get paid more?

Infusion nurses often earn higher wages compared to general nursing roles due to specialized skills in administering IV therapies and managing complex patient needs. Their compensation can also increase with experience, certifications, and working in high-demand settings or during overtime and weekend shifts. However, pay varies based on location, employer, and individual qualifications.

What are the most commonly searched types of Infusion Rn jobs in Saint Louis, MO?

The most popular types of Infusion Rn jobs in Saint Louis, MO are:

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For Weekend Infusion Rn jobs in Saint Louis, MO, the most frequently searched job titles are:

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What cities near Saint Louis, MO are hiring for Weekend Infusion Rn jobs?

Cities near Saint Louis, MO with the most Weekend Infusion Rn job openings:

Weekend Infusion Rn jobs near you
Infographic showing various Weekend Infusion Rn job openings in Saint Louis, MO as of August 2026, with employment types broken down into 1% As Needed, 66% Full Time, 29% Part Time, 3% Contract, and 1% Nights. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution, with an average salary of $92,951 per year, or $44.7 per hour.

IV Infusion Registered Nurse (PRN) - Southern, IL/St. Louis, MO

Dript IV Therapy

Saint Louis, MO • On-site

$48/hr

Per diem

PTO

This job post has expired 1 day ago. Applications are no longer accepted.

Job description

IV Infusion Registered Nurse (PRN) - Southern, IL/St. Louis, MO
Pay: $48 per hour
At Vitaline, we don't just talk about culture, we live it. Join a rapidly growing, compliance focused IV therapy company that's empowering wellness and elevating lives, one patient at a time.
We are currently hiring a PRN IV Infusion Registered Nurse (RN) to serve patients throughout the Southern, IL/St. Louis, MO area. Candidates must reside within a 30 minute commute of either our Swansea, IL office or St. Louis, MO office. This is a mobile infusion RN role serving skilled nursing facilities and long-term care centers. This role is ideal for experienced, compassionate nurses seeking flexible PRN work who are confident in IV therapy, comfortable working independently, and enjoy patient interaction in a mobile setting.
Why You'll Love Working with Us:
  • Vehicle Stipend
  • PTO Plan
  • No nights, weekends, or holidays
  • Supportive, empowering culture rooted in growth and respect

About the Role:
As a mobile IV infusion RN, you'll travel to skilled nursing facilities and long-term care centers to administer IV hydration and medication therapy to geriatric patients, many of whom are "hard sticks." Our patients depend on you to be accurate, skilled, and compassionate.
This is an excellent opportunity for hospital nurses, emergency room (ER) nurses, IV specialists, and Registered Nurses with long-term care experience who are seeking a PRN role with increased autonomy, flexible weekday scheduling, and the ability to step away from traditional hospital environments while continuing to make a meaningful clinical impact.
Travel Expectations:
  • Submit a minimum of six available weekdays per month by the 20th of the prior month
  • Daily travel to skilled nursing facilities and nursing homes required
  • Comfortable driving up to 1.5 hours one way (home every night!)
  • Many facilities are closer, but flexibility is key

Responsibilities/Qualifications:
  • Active RN Multi-State/Compact License with the ability to practice in both Missouri and Illinois (Required).
  • Administer intravenous (IV) infusions and medications
  • Assess patients and monitor vital signs
  • Maintain detailed and accurate patient records
  • Communicate effectively with physicians and facility staff
  • Ensure the safety, comfort, and dignity of all patients
  • Work independently and as part of a collaborative care team
  • Minimum 2 years of IV therapy experience
  • Reliable transportation and smartphone

Vitaline is on a mission to revolutionize patient-centered care by merging science, technology, and human compassion. We celebrate diversity and believe every team member brings unique value to our mission.
If you are looking for flexible PRN work, weekday-only scheduling, and the opportunity to grow with a mission driven clinical team, we encourage you to apply today.

Apply