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Weekend Clinical Trial Rn Jobs in Tyler, TX (NOW HIRING)

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Registered Nurse

Tyler, TX

$54K - $105K/yr

Night Shift: $4.50/hour * Weekend: $2.50/hour * All differentials are stackable Key ... At least 1 year of clinical experience preferred Relocation Assistance: Available to candidates ...

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Weekend Clinical Trial Rn information

See Tyler, TX salary details

$27

$58

$90

How much do weekend clinical trial rn jobs pay per hour?

As of Jul 28, 2026, the average hourly pay for weekend clinical trial rn in Tyler, TX is $58.91, according to ZipRecruiter salary data. Most workers in this role earn between $47.79 and $66.39 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Weekend Clinical Trial RN, and why are they important?

To thrive as a Weekend Clinical Trial RN, you need a current RN license, clinical nursing experience, and a solid understanding of Good Clinical Practice (GCP) guidelines. Familiarity with clinical trial management systems, electronic data capture (EDC) tools, and protocol documentation is typically required. Strong attention to detail, organizational skills, and effective communication are vital soft skills for coordinating with research teams and ensuring regulatory compliance. These skills and qualities are crucial for maintaining patient safety, data integrity, and adherence to study protocols during weekend trial operations.

What are some unique challenges of working as a Weekend Clinical Trial RN, and how can I prepare for them?

As a Weekend Clinical Trial RN, you may encounter challenges such as limited onsite support, managing urgent protocol issues, and balancing patient care with strict research timelines. Since weekends often have fewer staff members present, strong communication and problem-solving skills are essential. To prepare, familiarize yourself with study protocols in advance, establish clear lines of communication with the principal investigator and other team members, and ensure you are comfortable with electronic data capture systems. Being proactive and organized will help you provide excellent patient care while maintaining compliance with research requirements.

What are Weekend Clinical Trial RNs?

Weekend Clinical Trial RNs are registered nurses who work primarily on weekends to support clinical research studies. Their responsibilities include administering investigational treatments, monitoring patient safety, collecting data, and ensuring protocol compliance. They collaborate with research teams, patients, and other healthcare providers to facilitate trials and maintain high standards of care. This role is crucial for studies that require continuous patient oversight and data collection outside of standard weekday hours.

What is the difference between Weekend Clinical Trial Rn vs Weekend Research Nurse?

AspectWeekend Clinical Trial RnWeekend Research Nurse
CredentialsRegistered Nurse (RN) license, clinical trial trainingRegistered Nurse (RN) license, research-specific training
Work EnvironmentClinical trial sites, hospitals, research facilitiesResearch centers, hospitals, clinical research units
Employer & IndustryPharmaceutical companies, research organizationsAcademic institutions, research organizations
Work ScheduleWeekend shifts, flexible hoursWeekend shifts, flexible hours

Both roles involve RN credentials and work in research settings, often during weekends. The main difference lies in the focus: Weekend Clinical Trial Rns primarily support clinical trial protocols, while Weekend Research Nurses may be involved in broader research activities. Both roles are essential in advancing clinical research and typically require similar certifications and work environments.

What cities near Tyler, TX are hiring for Weekend Clinical Trial Rn jobs? Cities near Tyler, TX with the most Weekend Clinical Trial Rn job openings:
Weekend Clinical Trial Rn jobs near you
Infographic showing various Weekend Clinical Trial Rn job openings in Tyler, TX as of June 2026, with employment types broken down into 63% Full Time, 23% Part Time, and 14% Contract. Highlights an 77% Physical, 5% Hybrid, and 18% Remote job distribution, with an average salary of $122,535 per year, or $58.9 per hour.

Clinical Research Coordinator I - RN

Iterative Health

Tyler, TX • On-site

$65K - $81K/yr

Full-time

Posted 18 days ago

Job description

Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes.
We built a leading performance-driven network of 100+ sites across the US, Europe, India, and Australia, conducting research directly in the communities where care is delivered across gastrointestinal, hepatology, obesity, and cardiology. By combining deep clinical trial expertise with cutting-edge AI, we connect sponsors' scientific ambitions with high-performing research teams that expedite and expand access to novel therapeutics for patients in need. Today, Iterative Health is headquartered in Cambridge, Massachusetts, and New York City with 250+ employees world-wide.
A Clinical Research Coordinator I - RN at Iterative Health is an essential member of the site research team, supporting, facilitating, and coordinating the daily execution of clinical trials across our network. This role is at the heart of every study - managing patient interactions, ensuring protocol compliance, maintaining data integrity, and keeping the operational machinery of clinical research running smoothly.
The ideal candidate brings clinical research experience, a patient-first mindset, strong attention to detail, and the ability to thrive in a fast-paced, protocol-driven environment. This role provides a strong foundation for success while offering a clear path for professional growth within Iterative Health's expanding site network.
Where You'll Drive Impact
  • Administratively and clinically manage industry-sponsored clinical trials, including problem-solving, communication, and protocol management.
  • Schedule all patient research visits and procedures in accordance with protocol requirements.
  • Ensure relevant study and subject-specific information is entered into the CTMS on a regular basis.
  • Complete and maintain study documentation including consent forms, source documentation, progress notes, case report forms, and investigational accountability forms.
  • Complete and maintain case report forms per FDA guidelines, reviewing them against patient medical records for completeness and accuracy.
  • Schedule and prepare for monitor visits.
  • Maintain inventory of study equipment and supplies onsite at all times.
  • Lead patient recruitment activities including chart reviews, protocol discussions with patients, and verification of informed consent documentation.
  • Conduct patient visits as outlined within each study protocol.
  • Act as the primary point of contact for study participants throughout the course of the study.
  • Dispense study medication, collect vital signs, and perform ECGs per protocol.
  • Perform blood draws; process and ship specimens per study protocol and IATA regulations.
  • As assigned: place IVs, administer IV medications and fluids, give intramuscular and subcutaneous injections, monitor patients during infusion, and discharge patients in accordance with protocol and site policies.
  • Adhere to Research SOPs, Good Clinical Practice (GCP) guidelines, and study protocols at all times.
  • Assist with routine data verification and quality control, ensuring data integrity and consistency with prescribed study protocols.
  • Ensure all safety data is reviewed by the PI in a timely manner.
  • Cooperate with site compliance and monitoring efforts regarding the access, use, and disclosure of PHI; report instances of noncompliance to the appropriate compliance office.
  • Assist the study team in protecting the rights and welfare of all human research participants in accordance with federal regulations.
  • Maintain ongoing communication with the CRO, sponsor, research participants, Site Manager, and PI throughout the course of each study.
  • Actively participate in communication of status and results to management.
  • Perform job related duties as requested

What You Bring to the Team
  • Active Registered Nurse (RN) license required.
  • 1-2 years of clinical research experience strongly preferred .
  • Solid nursing background with a concentration in, or willingness to develop advanced knowledge of, GI specialty.
  • Ability to execute research tasks with guidance from experienced staff, PIs, and management.
  • Strong written and verbal communication skills.
  • Ability to read, interpret, and apply clinic policies and research protocols.
  • Proficiency in standard office software and CTMS platforms.
  • Highly organized with the ability to manage multiple priorities and meet deadlines.
  • Ability to work independently and collaboratively in a fast-paced environment.
Preferred Qualifications
  • Prior GI or hepatology clinical research experience.
  • Familiarity with GCP guidelines and FDA regulations governing clinical research.
  • Experience with CTMS, EDC, or eTMF platforms.
  • ACRP or SOCRA certification (CCRC or CCRP), or active pursuit of certification.

At Iterative Health, we're actively working towards creating an environment that is representative of the diversity of patients our technology serves. We are focused on building an equitable and inclusive culture, and by extension, hiring process. If you require any accommodations to make the application process or interviewing experience more accessible to you, please contact CandidateAccommodations@iterative.health.

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