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Vp Infrastructure Jobs in California (NOW HIRING)

Ionis

Vice President, Compliance

Carlsbad, CA · On-site +1

$129K - $174K/yr

VICE PRESIDENT, COMPLIANCE SUMMARY The Vice President, Compliance is the senior leader responsible ... scaled compliance infrastructure; oversee governance, compliance risk assessment, and ...

AppJaxx

VP of Operations

San Francisco, CA · On-site

Position Overview The VP of Operations will oversee and optimize all day-to-day operations while building scalable infrastructure to support rapid growth. This role is critical in ensuring alignment ...

Eleven Recruiting

VP of Infrastructure

Pasadena, CA · On-site

Their client, a wealth management firm, is seeking a VP of Infrastructure to oversee and enhance infrastructure systems, lead the transition to cloud solutions, and manage multiple infrastructure ...

Digital NEST

Vice President of Development

San Jose, CA · On-site

$140K - $155K/yr

The VP will be responsible for developing and executing fundraising strategies that support the ... Development Operations & Infrastructure (15%) * Build and strengthen development systems, processes ...

Digital NEST

Vice President of Development

San Jose, CA · On-site

$140K - $155K/yr

The VP will be responsible for developing and executing fundraising strategies that support the ... Development Operations & Infrastructure (15%) * Build and strengthen development systems, processes ...

Hp

Vice President, Reliability

Palo Alto, CA · On-site

$211K - $272K/yr

Vice President, Reliability Description - HP is a technology company founded on the belief that ... AI, security, infrastructure, reliability and device software, as well as software stacks for ...

Druva

Vice President, Finance

Santa Clara, CA · On-site

As a key steward of financial performance, the VP of Finance will also lead improvements in financial infrastructure, support communications with the board, and help shape the future of the business ...

Skyryse

Vice President, Operations

El Segundo, CA · On-site

$200K - $280K/yr

VICE PRESIDENT, OPERATIONS - EL SEGUNDO, CA We are seeking a highly skilled and experienced Vice ... Direct IT strategy and infrastructure, including ERP/MRP and business systems, end-user support ...

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Showing results 21-40

All JobsVp Infrastructure JobsVp Infrastructure Jobs in California

Vp Infrastructure information

See California salary details

$69.1K

$151.7K

$224.5K

How much do vp infrastructure jobs pay per year?

As of Sep 8, 2026, the average yearly pay for vp infrastructure in California is $151,669.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,000.00 and $185,000.00 per year, depending on experience, location, and employer.

What does a VP of Infrastructure do?

As a VP of infrastructure, you manage the systems that a company or organization uses for operations. In some businesses, your duties focus on developing, testing, and improving all aspects of an organization's IT systems. In addition to the management of current infrastructure, you also oversee long-term planning and development. Your responsibilities include ensuring that the company has the technical tools and equipment needed to meet operational needs at the current time and in the future.

What does a VP of Infrastructure do?

A VP of Infrastructure oversees the planning, implementation, and maintenance of an organization’s technology infrastructure, including networks, servers, data centers, and cloud services. They develop strategies to ensure system reliability, scalability, and security, while managing teams of IT professionals. This role also involves budgeting, vendor management, and aligning IT infrastructure with the company's business objectives to support growth and innovation.

What are the key skills and qualifications needed to thrive as a VP Infrastructure, and why are they important?

To thrive as a VP Infrastructure, you need deep expertise in IT infrastructure management, strategic planning, and a relevant degree—often supported by experience in large-scale system design and leadership. Familiarity with platforms like AWS, Azure, VMware, as well as ITIL or PMP certifications, is typically required to oversee complex technology environments. Strong leadership, communication, and problem-solving skills distinguish top performers in this role. These capabilities are crucial for ensuring robust, scalable, and secure infrastructure that aligns with business objectives.

How does a VP of Infrastructure typically collaborate with other departments to ensure seamless IT operations?

A VP of Infrastructure regularly works cross-functionally with teams such as security, application development, and business operations to align infrastructure strategies with organizational goals. This role often leads discussions around resource allocation, risk mitigation, and project prioritization to ensure that infrastructure supports both current and future business needs. Effective collaboration is essential for integrating new technologies, maintaining uptime, and responding to incidents quickly. Strong communication and leadership skills are crucial, as the VP is often tasked with translating technical requirements into business value for executive stakeholders.
More about Vp Infrastructure jobs

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What are popular job titles related to Vp Infrastructure jobs in California?

For Vp Infrastructure jobs in California, the most frequently searched job titles are:

What job categories do people searching Vp Infrastructure jobs in California look for?

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What cities in California are hiring for Vp Infrastructure jobs?

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Vp Infrastructure jobs near you
Infographic showing various Vp Infrastructure job openings in California as of August 2026, with employment types broken down into 84% Full Time, 11% Part Time, and 5% Contract. Highlights an 82% Physical, 5% Hybrid, and 13% Remote job distribution, with an average salary of $151,669 per year, or $72.9 per hour.

Vice President, Compliance

Ionis

Carlsbad, CA • On-site, Remote

$129K - $174K/yr

Full-time

Re-posted 9 days ago

Job description

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
VICE PRESIDENT, COMPLIANCE
SUMMARY
The Vice President, Compliance is the senior leader responsible for the strategy, execution, and effectiveness of Ionis' corporate compliance program. Reporting to the Senior Vice President, Chief Compliance & Quality Assurance Officer, the Vice President, Compliance directly manages Compliance Counsel and compliance professionals and sets the function's priorities, operating plan, resources, and talent agenda within delegated authority.
As Ionis expands commercialization and prepares for future product launches, this leader will build and maintain a risk-based, appropriately scaled compliance infrastructure; oversee governance, compliance risk assessment, and investigations; and provide clear recommendations and escalation to executive leadership and relevant governance committees. The Vice President, Compliance will help play a critical role fostering a culture in which employees raise concerns early, leaders act with integrity, and Compliance is a trusted, pragmatic partner to the business.
Success in this role requires strategic judgment, executive presence, programmatic expertise, and the ability to influence across a complex matrix while developing a high-performing Compliance organization.
WORK LOCATION: Carlsbad, CA (Preferred)
RESPONSIBILITIES
  • Lead the Company's Executive Compliance Committee and substantively support the Commercial Operations and Compliance Oversight Committee of the Board of Directors in its operations.
  • Serve as a key subject matter expert and strategic advisor on healthcare compliance matters, overseeing the development and ongoing enhancement of compliance policies, procedures, business practices, and guidelines that reflect applicable laws, regulations, guidance, codes, and industry standards.
  • Partner with executive leadership, the Chief Compliance Officer, the Chief Legal Officer, and the Commercial Operations and Compliance Oversight Committee to establish and reinforce a strong tone from the top and embed ethical conduct into leadership communications, business operations, strategic initiatives, and organizational culture.
  • Actively engage with Commercial, Medical, Clinical, Regulatory, and other business partners to provide proactive, practical compliance guidance on strategic and tactical initiatives, including product launch and commercialization activities.
  • Drive the implementation, maintenance, and continuous improvement of a robust and effective healthcare compliance program that is aligned to Ionis' corporate strategy, commercialization plans, and risk profile.
  • Oversee and conduct compliance investigations into allegations of violations of applicable laws, regulations, or Company policies, and ensure appropriate corrective and preventive actions are implemented.
  • Oversee Compliance representation on Ionis' promotional and medical review committees, assuring consistent advice and guidance, as applicable.
  • Advise on key areas of engagement with healthcare professionals, including grants and sponsorships, donations, advisory boards, speaker programs, third-party due diligence, and other key risk areas.
  • Manage, coach, and develop Compliance Counsel and compliance professionals, including setting clear expectations, providing timely feedback, conducting performance reviews, and addressing performance issues.
  • Conduct ongoing compliance risk assessments and regularly evaluate ethics and compliance issues, trends, regulatory developments, and the effectiveness of the Company's compliance culture; recommend enhancements based on business needs, emerging risks, and regulatory expectations.
  • Foster a safe and open environment in which employees feel comfortable speaking up and raising concerns, and in which Compliance is viewed as a trusted strategic partner.
  • Collaborate with Compliance Operations on the compliance training and communications strategy, translating legal and regulatory requirements into engaging, practical, and business-relevant guidance.
  • Develop and manage the functional budget and workforce plan, including headcount, external counsel, vendors, technology, and other resources required to deliver the Compliance program effectively.
  • Support other responsibilities in service of the Compliance team, functional, and/or corporate strategies and goals.

REQUIREMENTS
  • Juris Doctor (J.D.) degree from accredited United States law school required.
  • Minimum of 15 years of relevant healthcare compliance experience in the biotechnology, pharmaceutical, medical device, and/or life sciences industry, with demonstrated experience designing, implementing, and enhancing comprehensive compliance programs.
  • Experience supporting one or more U.S. biopharmaceutical product launches and/or commercial-stage operations preferred.
  • Demonstrated commitment to ethics, integrity, values-based leadership, and the highest standards of quality.
  • Deep knowledge of U.S. healthcare compliance laws, regulations, guidance, and industry best practices, including requirements relating to product advertising and promotion, healthcare professional interactions, grants and sponsorships, transparency reporting, training, investigations, and policy development.
  • Proven ability to serve as a strategic advisor within a complex, matrixed organization; influence and engage stakeholders at all levels, including executive leadership; and provide pragmatic advice while navigating ambiguity.
  • Excellent leadership, project management, analytical, and problem-solving skills, with the ability to manage multiple priorities simultaneously and consistently deliver high-quality results in a fast-paced and rapidly evolving environment.
  • Exceptional oral, written, and presentation skills, with professionalism, judgment, and discretion to handle highly confidential and sensitive matters.
  • A resilient, adaptable, hands-on leader who is willing to engage at all levels of activity within a growing and dynamic company environment.
  • A positive, respectful, inclusive, and collaborative individual who fosters trust, encourages others, and strengthens organizational agility.
  • Excited by Ionis' patient-centric mission to improve the lives of patients living with serious diseases.
  • Ability to travel approximately 15-20% of the time.

Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition #IONIS004092
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
Full Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits
The pay scale for this position is $280,000 to $325,000
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws.
For further information, please review the Know Your Rights notice from the Department of Labor.

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