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Upstream Process Development Jobs in Hyattsville, MD

ProSidian Consulting

Geophysicist

Washington, DC · On-site +1

... Upstream Oil & Gas (Exploration and production | Reservoir development | Drilling programs ... Business Management - Coordinating people, processes, and resources to achieve strategic objectives ...

ProSidian Consulting, LLC

Geophysicist

Washington, DC · On-site +1

... Upstream Oil & Gas (Exploration and production | Reservoir development | Drilling programs ... Business Management - Coordinating people, processes, and resources to achieve strategic objectives ...

ProSidian Consulting

Petroleum Engineer

Washington, DC · On-site +1

... and field development analysis for upstream oil and gas projects. These assessments support ... Business Management - Coordinating people, processes, and resources to achieve strategic objectives ...

Drayer Physical Therapy

Physical Therapist

Fulton, MD · On-site

$1.6K - $2.1K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

Drayer Physical Therapy

Physical Therapist

Fulton, MD · On-site

$78K - $95K/yr

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

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Showing results 21-40

All JobsUpstream Process Development JobsUpstream Process Development Jobs in Hyattsville, MD

Upstream Process Development information

See Hyattsville, MD salary details

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How much do upstream process development jobs pay per hour?

As of Aug 21, 2026, the average hourly pay for upstream process development in Hyattsville, MD is $26.58, according to ZipRecruiter salary data. Most workers in this role earn between $23.61 and $27.93 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in upstream process development?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What are common upstream process development jobs?

Common upstream process development jobs include roles such as upstream process scientist, process engineer, and bioprocess development specialist. These positions focus on optimizing cell culture, fermentation, and bioreactor processes to improve product yield and quality, often requiring knowledge of bioreactor operation, cell biology, and process scale-up. Skills in laboratory techniques, process modeling, and regulatory compliance are also important in these roles.

What is an upstream process development job?

An upstream process development job involves designing, optimizing, and scaling the early stages of biopharmaceutical production, such as cell culture and fermentation processes. Professionals in this role typically work with bioreactors, laboratory equipment, and process analytical tools to improve yield and quality of biological products. Strong knowledge of microbiology, biochemistry, and process engineering is essential, along with adherence to regulatory standards.

What are popular job titles related to Upstream Process Development jobs in Hyattsville, MD?

For Upstream Process Development jobs in Hyattsville, MD, the most frequently searched job titles are:

What job categories do people searching Upstream Process Development jobs in Hyattsville, MD look for?

The top searched job categories for Upstream Process Development jobs in Hyattsville, MD are:

What cities near Hyattsville, MD are hiring for Upstream Process Development jobs?

Cities near Hyattsville, MD with the most Upstream Process Development job openings:

Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in Hyattsville, MD as of August 2026, with employment types broken down into 94% Full Time, and 6% Part Time. Highlights an 94% In-person, and 6% Remote job distribution, with an average salary of $55,278 per year, or $26.6 per hour.

Senior Metabolic & Biomanufacturing Process Engineer

Johns Hopkins Applied Physics Lab

Laurel, MD • On-site

$105 - $290/hr

Other

Posted 15 days ago

Job description

Description

Do you marvel at the complexity of metabolism and seek to leverage natural metabolisms in creative ways to develop new technologies?

Do you want to apply your expertise in biomanufacturing process engineering to pressing National Security challenges?

Do you love contributing your microbial metabolic engineering and downstream processing subject matter expertise to an interdisciplinary team of scientists, focused on developing novel applications?

If you answered yes to these questions, we're looking for someone like you to join our team in the Biological Sciences Group, here at the Johns Hopkins University Applied Physics Lab.

We are seeking a highly motivated metabolic and bioprocess engineer to contribute to a team focused on engineering microbial metabolic pathways and optimizing biomanufacturing processes, including upstream and downstream processing. As part of the Biological Sciences Group, in the Research Exploratory Development Department, you will be at the forefront of APL's mission to provide impactful contributions to critical challenges. You will contribute to building outstanding expertise in molecular biology, in the pursuit of challenges in national security.

As a Senior Metabolic & Biomanufacturing Process Engineer
  • Design, implement, and characterize recombinant metabolic pathways in microbial organisms.
  • Design, implement, and optimize biomanufacturing processes.
  • Lead projects and teams for both internally funded and externally funded efforts in the research areas mentioned above.
  • Support new business development activities to expand program scope within the Research and Exploratory Development Department and other business areas across APL, including concept development, proposal writing, and project execution.
  • Work with a technical team providing leadership in the development of new opportunities and support internal initiatives, driving technical innovation and growth in areas relevant to APL sponsors.
  • Participate in the broader APL community by presenting data to interdisciplinary groups and to department management.
  • Develop and maintain effective working relationships with external sponsors.
Qualifications

Minimum qualifications:

  • Have a PhD in Biological Engineering, Chemical Engineering, Molecular Biology or a similar field.
  • Have extensive wet lab experience manipulating the metabolism of microbes and in scaling metabolite synthesis and downstream processing.
  • Have 2+ years experience with analytical chemistry techniques and equipment including HPLC, GC/MS, or LC/MS.
  • Are proficient in molecular biology techniques, including DNA manipulation and plasmid construction, qPCR, protein analysis, plate-reader assay development, microscopy techniques, and microbial cell culture.
  • Have experience designing, executing, and troubleshooting a wide range of biological assays.
  • Possess strong leadership skills, including excellent written and verbal communication skills, demonstrated through a combination of publication record, teaching, and professional experience.
  • Are able to obtain an Interim Secret level security clearance by your start date and can ultimately obtain a TS/SCI level clearance. Eligibility requires U.S. citizenship.
You’ll go above and beyond
  • Have experience working with non-lab adapted or anaerobic microbes such as Rhodopseudomonas palustris and Pseudomonas aeruginosa.
  • Have experience with yeast, plant, algae, or microbiome systems.
EEO Statement

All qualified applicants will receive consideration for employment without regard to race, creed, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, physical or mental disability, genetic information, veteran status, occupation, marital or familial status, political opinion, personal appearance, or any other characteristic protected by applicable law. APL is committed to providing reasonable accommodation to individuals of all abilities, including those with disabilities. If you require a reasonable accommodation to participate in any part of the hiring process, please contact Accessibility@jhuapl.edu.

Compensation

Minimum Rate: $105,000 Annually

Maximum Rate: $290,000 Annually

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