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Upstream Process Development Jobs in North Carolina

Amgen

Senior Process Engineer

Holly Springs, NC · On-site

$90K - $116K/yr

This may include development of business case for improvement and identification of design ... Provide rotational on-call support and ensure 24x7 day-to-day reliability of Upstream and ...

New

Amgen, Inc.

Senior Process Engineer

Holly Springs, NC · On-site

$90K - $116K/yr

This may include development of business case for improvement and identification of design ... Provide rotational on-call support and ensure 24x7 day-to-day reliability of Upstream and ...

Upstream Rehabilitation

Physical Therapist

Surf City, NC · On-site

$1.3K - $1.7K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. time, or PRN). Specific details will ...

Upstream Rehabilitation

Physical Therapist

High Point, NC · On-site

$1.4K - $1.9K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

Upstream Rehabilitation

Physical Therapist

Mount Airy, NC · On-site

$1.4K - $1.8K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

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All JobsUpstream Process Development JobsUpstream Process Development Jobs in North Carolina

Upstream Process Development information

See North Carolina salary details

$17

$24

$34

How much do upstream process development jobs pay per hour?

As of Jul 17, 2026, the average hourly pay for upstream process development in North Carolina is $24.10, according to ZipRecruiter salary data. Most workers in this role earn between $21.39 and $25.34 per hour, depending on experience, location, and employer.

What jobs pay 500,000 a year in the US?

In the field of Upstream Process Development, senior roles such as Director or Vice President can reach or exceed $500,000 annually, especially with bonuses and stock options. These positions typically require extensive experience, advanced degrees, and leadership skills in biopharmaceutical or biotech industries. High compensation is often associated with managerial responsibilities, strategic decision-making, and overseeing large teams or projects.

What are the key skills and qualifications needed to thrive in Upstream Process Development, and why are they important?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are common upstream jobs?

Common upstream process development jobs include roles such as upstream process scientist, bioprocess engineer, and fermentation scientist. These positions focus on developing and optimizing the early stages of biopharmaceutical production, often requiring knowledge of cell culture, bioreactor operation, and process scale-up. Skills in laboratory techniques, process analytical technology, and regulatory compliance are also important in these roles.

What biology jobs pay over $100k?

In upstream process development, senior roles such as Process Development Managers, Principal Scientists, and Regulatory Affairs Directors often have salaries exceeding $100,000. These positions typically require advanced degrees, extensive industry experience, and expertise in bioprocessing, quality control, or regulatory compliance.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What is upstream process development?

Upstream process development involves designing and optimizing the initial stages of biopharmaceutical production, such as cell culture and fermentation, to produce target biological products. It requires knowledge of bioprocessing, cell biology, and often involves working with bioreactors and process control systems to ensure consistent, high-quality output.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.
What are popular job titles related to Upstream Process Development jobs in North Carolina? For Upstream Process Development jobs in North Carolina, the most frequently searched job titles are:
What job categories do people searching Upstream Process Development jobs in North Carolina look for? The top searched job categories for Upstream Process Development jobs in North Carolina are:
What cities in North Carolina are hiring for Upstream Process Development jobs? Cities in North Carolina with the most Upstream Process Development job openings:
Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in North Carolina as of July 2026, with employment types broken down into 1% As Needed, 81% Full Time, 13% Part Time, 1% Temporary, and 4% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $50,121 per year, or $24.1 per hour.
Manufacturing Associate, Bulk Drug Substance Upstream - Days

Manufacturing Associate, Bulk Drug Substance Upstream - Days

Amgen, Inc.

Holly Springs, NC • On-site

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 17 days ago

Job description

Career Category
Manufacturing
Job Description
HOW MIGHT YOU DEFY IMAGINATION?
You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Manufacturing Associate, Bulk Drug Substance Upstream - Days
Live
What you will do
Let's do this! Let's change the world! In this dynamic role, you will be an Associate in the manufacturing organization at Amgen North Carolina (ANC). The schedule is a rotating 2-2-3, 5:45AM-6:15PM (12-hour shift). Associates will be completing operations on the floor in our upstream area and are responsible for the manufacturing of cGMP (Current Good Manufacturing Practices) drug substance.
With general direction, the Associate will support all floor operations in accordance with cGMP practices.
Responsibilities will include...
Compliance:
  • Completes work in accordance with established cGMP procedures and policies (Standard Operating Procedures [SOPs], Manufacturing Procedures [MPs], Job Hazard Analysis [JHAs], Code of Federal Regulations [CFR]) with strict adherence to safety and compliance

  • Assure proper gowning and aseptic techniques are always followed

Process/Equipment/Facilities:
  • Perform hands-on operations including set-up, cleaning, sanitization, monitoring of equipment and assigned area

  • Run and monitor critical process tasks per assigned procedures

  • Perform in-process sampling, operate analytical equipment, and complete process documentation (Electronic Batch Records [EBRs])

  • Identify and escalate issues and concerns regarding daily routine functions related to process and tasks; may engage with team on potential solutions

  • Perform documentation for assigned functions (i.e., equipment logs, EBRs)

  • Collaborate as part of a cross-functional team (i.e., QA/QC, F&E (Facilities & Engineering), PPIC, Mfg., PD (Process Development), Regulatory, etc.) in completing production activities

  • Maintain an organized, clean, and workable space

Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The hard-working professionals we seek are team players with these qualifications.
Basic Qualifications:
  • High School/GED + 2 years manufacturing and/or other regulated environment experience

Or
  • Associate's Degree + 6 months manufacturing and/or other regulated environment experience

Or
  • Bachelor's Degree

Preferred Qualifications:
  • Completion of NC BioWorks Certification Program

  • Experience in a regulated industry such as biotechnology or pharmaceutical

  • Basic understanding and process experience in a cGMP manufacturing facility

  • Excellent verbal and written communication

  • Proficient Microsoft Office skills, and knowledge of other electronic systems such as EBR/MES, Delta V, and Electronic Quality Systems

  • An ability to demonstrate desire and drive to learn and grow their understanding of operations and processes

Thrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
#AmgenNorthCarolina
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Salary Range
70,985.20USD -96,038.80 USD

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