Upstream Process Development Scientist Jobs in Washington

Scientist (Analytical Development, Cell Therapy)

Summary of the group

Join our Cell Therapy Analytical Development team, where we develop and deliver robust, technologically advanced biological assays to progress cell therapy products from research to commercial stages. Our team supports the end-to-end biological and bioanalyticalcharacterization ofviral vectorandcell therapy products, enablingmanufacturing processes, formulation, drug product development, and regulatory filings from IND to BLA and beyond. We collaborate closely with analytical quality and several cross-functional teams, including clinical, regulatory, QA, and manufacturing.

Accountabilities

• Develop robustfunctional, characterization, and molecular analytical methods including method qualification and transfer.

• Make detailed observations, analyze data, interpret results, and exerciseappropriate technicaldiscretion in the design, execution, and interpretation of experiments independently.

• Carry outanalytical development/sample testing to enablelentiviral vectorupstream and downstream processdevelopment.

• Author/reviewtechnical reports, protocols, and technical summaries for presentation.

• Present and discuss experimental results at group/project team meetings.

• Workin a team-based structure and interface with research and process development departments.

Essential Skills/Experience

• Bachelor's degree in Immunology, Cell Biology, Biological Sciences, Biotechnology, or related field with5+years of relevant experience or aMaster'sdegree in Immunology, Cell Biology, Biological Sciences, Biotechnology, or related field with3+ years of relevant experience.

• Biotechnology or pharmaceutical industry experience working withanalyticalforlentiviral vectorand CAR T cellsisrequired.

• Experiencemethod qualification/validationandtech transfer ofcell and gene therapy analytical methods isarequired.

• Highly proficientinimmunology techniques isrequired, such asELISA or similar technology platforms.

• Highly proficientinmolecular biologytechniques isrequired, such asqPCR,dPCR,for gene edit evaluation,on target/off target analysis.

• Exhibit excellent written and oral communication skills.

• Good timemanagement and organizational skills with the ability to prioritize tasks from multiple projects to meet timelines.

Desirable Skills/Experience

• Experience inbiophysicalanalysissuch as DLS, HPLC,massspectrometry and capillary electrophoresis, Flowvirometryis a plusfor lentiviral vectorcharacterization isa plus.

• Experience withNGS is a plus

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work atpaceand challenge perceptions.That'swhy we work, on average, a minimum of three days per week from the office. But thatdoesn'tmeanwe'renot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and make people's lives better. Our inclusive network of diverse and high-performing teams supports each other with trust and respect. We thrive on curiosity and problem-solving, constantly learning and evolving. With opportunities for global careers and great rewards, AstraZeneca is where you can make a real impact.Ready to make a difference? Apply now to join our team!

The annual base pay for this position ranges from $90,961 to $136,441. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.