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How much do upstream process development scientist jobs pay per hour?

As of Aug 6, 2026, the average hourly pay for upstream process development scientist in Pennsylvania is $38.76, according to ZipRecruiter salary data. Most workers in this role earn between $28.41 and $46.25 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an upstream process development scientist, and why are they important?

To thrive as an Upstream Process Development Scientist, you need a strong background in bioprocess engineering, cell culture, and molecular biology, typically supported by a degree in life sciences or biochemical engineering. Familiarity with bioreactor systems, analytical instrumentation, and data analysis software, as well as experience with cGMP and regulatory guidelines, is essential. Strong problem-solving abilities, teamwork, and effective communication help drive innovation and collaboration in the lab. These skills are crucial for optimizing cell culture processes, ensuring product quality, and meeting timelines in biopharmaceutical development.

What are some typical challenges faced by an upstream process development scientist, and how are they addressed in the workplace?

Upstream Process Development Scientists often encounter challenges such as optimizing cell culture conditions for maximum yield, scaling up processes from bench to pilot or production scale, and troubleshooting variability in biological systems. These challenges are typically addressed through rigorous experimental design, close collaboration with cross-functional teams like analytical development and quality assurance, and leveraging data-driven approaches to problem-solving. Regular team meetings and access to advanced instrumentation also provide support, ensuring that scientists can quickly adapt to evolving project needs and industry standards.

What does an upstream process development scientist do?

An Upstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes for the production of biological products such as proteins, vaccines, or antibodies. They primarily focus on cell culture, fermentation, and bioreactor operations to maximize yield and product quality. These scientists work closely with research and manufacturing teams to develop efficient and reproducible processes that can be transferred to large-scale production. Their work is essential in the biotechnology and pharmaceutical industries for the development of new therapeutics.

What is the difference between Upstream Process Development Scientist vs Downstream Process Development Scientist?

AspectUpstream Process Development ScientistDownstream Process Development Scientist
Focus AreaBioreactor cultivation, cell culture optimization, media developmentPurification, filtration, chromatography, product recovery
Skills & CertificationsCell biology, bioprocessing, GMP regulationsProtein chemistry, purification techniques, GMP compliance
Work EnvironmentLaboratories, bioreactors, pilot plantsLaboratories, purification facilities, pilot plants
Industry UsageBiopharmaceuticals, biotech companies, contract manufacturingBiopharmaceuticals, biotech companies, contract manufacturing

Both roles are essential in bioprocessing, with upstream scientists focusing on cell growth and media optimization, while downstream scientists handle product purification. They often collaborate closely within biopharmaceutical manufacturing to ensure efficient production and high-quality biologics.

What are popular job titles related to Upstream Process Development Scientist jobs in Pennsylvania? For Upstream Process Development Scientist jobs in Pennsylvania, the most frequently searched job titles are:
What job categories do people searching Upstream Process Development Scientist jobs in Pennsylvania look for? The top searched job categories for Upstream Process Development Scientist jobs in Pennsylvania are:
Upstream Process Development Scientist jobs near you
Infographic showing various Upstream Process Development Scientist job openings in Pennsylvania as of July 2026, with employment types broken down into 1% As Needed, 80% Full Time, 17% Part Time, and 2% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $80,613 per year, or $38.8 per hour.

Drug Product Formulation Development Scientist - AAV Gene Therapy

Eurofins USA PSS Insourcing Solutions

Philadelphia, PA

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 17 days ago

Job description

Company Description

The work we do at Eurofins Professional Scientific Services matters, and so do our employees. At Eurofins PSS, we put a focus on your professional growth. We provide our employees the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording you work-life balance and a competitive benefits package.

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

If you’re looking for a rewarding career, a place to call home, apply with us today!

Job Description

Eurofins PSS is seeking a Drug Product Formulation Development Scientist to permanently work at a client site to support drug product formulation, biophysical characterization, and process development for gene therapy research. The successful employee will thrive in a high throughput environment, working with small-scale drug product manufacturing process development and scale-up activities.

Position Responsibilities:

  • Drug product formulation, delivery, and process development activities in support of AAV gene therapy research in a small-scale manufacturing facility
  • Complete stability and release studies, scale-up and more
  • Utilize analytical characterization techniques via operation and troubleshooting of HPLC, HIAC, HAOL, and other instrumentation on raw materials and drug products
  • Collaborate with multiple teams throughout study timeline
  • Data analysis, interpretation, reporting, and presentation
Qualifications

Basic Minimum Qualifications:

  • BS in a life sciences discipline (Biology, Molecular Biology, Pharmaceutical Sciences, etc.) with at least 2 years of pharmaceutical industry experience working specifically in drug product formulation development.
  • Must have experience with HPLC
  • Ability to understand and follow report protocols and coordinate with multiple cross-functional teams
  • Must be eligible to work in the United States indefinitely without restriction or sponsorship

Preferred Qualifications:

  • Experience with HIAC and HAOL is highly preferred
  • Experience working with AAV gene therapies

Additional Information

The position is full-time, first shift, Monday-Friday with overtime as needed. Candidates living within a commutable distance of Philadelphia, PA are encouraged to apply.

Excellent full-time benefits include:

  • Comprehensive medical coverage, dental, and vision options
  • Life and disability insurance
  • 401(k) with company match
  • Paid vacation and holidays

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.