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Upstream Bio Jobs in Lexington, MA (NOW HIRING)

Vor Bio

Accountant/Sr Accountant

Boston, MA · On-site

$110K - $135K/yr

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... Vor Bio is seeking a motivated Accountant or Senior Accountant to join a growing and dynamic team.

Vor Bio

Director/ Senior Director, Regulatory CMC

Boston, MA · On-site

$163K - $215K/yr

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... Vor Bio is seeking an exceptional and highly motivated CMC leader Director/Sr Director Regulatory ...

Vor Bio

Senior Director/ Director Regulatory Strategy

Boston, MA · On-site

$163K - $215K/yr

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation ...

Vor Bio

Senior/Clinical Trial Manager (CTM)

Boston, MA · On-site

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation ...

Vor Bio

Associate Director Clinical Operations

Boston, MA · On-site

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation ...

Vor Bio

Digital Technology Lead - Data and AI

Boston, MA · On-site

  • Medical

  • Retirement

  • PTO

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation ...

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All JobsUpstream Bio JobsUpstream Bio Jobs in Lexington, MA

Upstream Bio information

See Lexington, MA salary details

$32.6K

$67.2K

$122.5K

How much do upstream bio jobs pay per year?

As of Aug 19, 2026, the average yearly pay for upstream bio in Lexington, MA is $67,158.00, according to ZipRecruiter salary data. Most workers in this role earn between $47,800.00 and $78,600.00 per year, depending on experience, location, and employer.

What is an upstream bio scientist?

An Upstream Bio scientist focuses on the early stages of bioprocessing, specifically cultivating and optimizing the growth of cells or microorganisms to produce desired biological products such as proteins or antibodies. Their work includes developing cell lines, optimizing culture conditions, scaling up processes from laboratory to industrial scale, and ensuring high yields and quality. Upstream Bio scientists play a critical role in biotechnology, pharmaceuticals, and biomanufacturing, working closely with downstream processing teams to ensure efficient and successful product development.

What does an upstream bioprocessing scientist do?

Upstream bioprocessing professionals typically focus on cultivating and optimizing cell cultures to produce biological products such as proteins or vaccines. Daily tasks often include preparing media, monitoring bioreactor parameters, sampling and analyzing cell growth, and troubleshooting process deviations. Collaboration with downstream processing teams and quality control is frequent to ensure seamless handoff and product quality. Additionally, maintaining detailed records and contributing to process improvement initiatives are key parts of the role.

What skills and qualifications are needed to thrive as an upstream bioprocessing scientist?

To thrive as an Upstream Bioprocessing Scientist, you need a strong background in biology, chemistry, and biochemical engineering, typically supported by a degree in a related field. Experience with bioreactors, cell culture systems, process optimization, and familiarity with GMP regulations and analytical tools are essential. Problem-solving, teamwork, and attention to detail are crucial soft skills for excelling in complex laboratory environments. These competencies ensure efficient development and scaling of biologics production, directly impacting product quality and regulatory compliance.

What is the difference between Upstream Bio vs Downstream Bio?

AspectUpstream BioDownstream Bio
Focus AreaEarly-stage research, target discovery, molecular biologyProduct development, manufacturing, formulation
Required CredentialsBiochemistry, molecular biology, cell biology degreesBiochemistry, pharmaceutical sciences, chemical engineering degrees
Work EnvironmentResearch labs, biotech startups, academic collaborationsManufacturing facilities, quality control labs, biotech companies

Upstream Bio primarily involves early research and target identification, while Downstream Bio focuses on product development and manufacturing processes. Both roles require strong backgrounds in biology or chemistry, but they differ in their specific focus areas and work environments. Understanding these differences helps professionals choose the right career path within the biotech industry.

What cities near Lexington, MA are hiring for Upstream Bio jobs?

Cities near Lexington, MA with the most Upstream Bio job openings:

Upstream Bio jobs near you
Infographic showing various Upstream Bio job openings in Lexington, MA as of August 2026, with employment types broken down into 82% Full Time, 13% Part Time, and 5% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $67,158 per year, or $32.3 per hour.

Process Engineer - Upstream/Downstream

Integrated Resources INC

Devens, MA

Contractor

Re-posted 20 hours ago

Job description

Company Description

Client is a global bio-pharmaceutical company

Job Description

The successful candidate will provide meaningful contributions toward commercial manufacturing support, process monitoring, technology transfer and process validation activities. The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation skills (memos, protocols, reports).

Responsibilities:

Work independently to provide commercial manufacturing technical support, process monitoring, technology transfer and process validation activities for downstream processes.

Provide process troubleshooting during scale-up and routine manufacturing.

Provide process subject matter expertise and ownership of assigned deliverables.

The successful candidate will work effectively in highly cross-functional project teams, matrix management environments, as well as independent working environments to support the site.

Perform data analysis and monitoring for process performance and product quality outputs.

The position will interface with Manufacturing, Quality, Engineering, and internal MS&T departments at multiple sites throughout the Client network

Strong communication and technical writing skills are required.

Qualifications

B.S./M.S. or Ph.D. in Chemical Engineer, Biochemical Engineer, Biomedical Engineer, Biochemistry or related field (Advanced degree is preferred)

Required: Prior experience (Ph.D: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bioprocessing (upstream and/or downstream)

Preferred: Prior experience scaling up biopharma manufacturing processes (upstream/downstream), facility fit assessments, process scale-up from bench/pilot to production, process troubleshooting and optimization, and process validation.

Hands-on experience working with chromatography, ultrafiltration and depth filtration process acquired through lab, pilot or production scale experience.

Preferred: Experience performing manufacturing investigations for biologics manufacturing.

Preferred: Experience providing start-up support for new biologics manufacturing processes (Person-In-Plant)

Preferred: Experience with statistical methodologies (DOE, SPC, etc), cGMP regulations, and regulatory requirements is expected.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Integrated Resources logo

About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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