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Temp Computational Structural Biology Jobs (NOW HIRING)

Output Biosciences

Head of Biology

New York, NY · On-site

$120K - $250K/yr

You have a PhD in computational biology, biophysics, structural biology, molecular biology, or a related biological field with 3+ years of post-doctoral or industry research experience * You have ...

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As of Jun 10, 2026, the average hourly pay for temp computational structural biology in the United States is $23.42, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $25.72 per hour, depending on experience, location, and employer.
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Sr. Director/Executive Director, Computational Chemistry

Sr. Director/Executive Director, Computational Chemistry

Prelude Therapeutics Incorporated

Wilmington, DE

Other

Posted 10 days ago

Job description

Description

We are seeking a highly accomplished and hands-on Executive Director of Computational Chemistry to build and lead our computational drug discovery capabilities in a fast-growing biotech environment. This leader will drive the design of novel small molecules against high-value biological targets using structure-based drug design (SBDD), physics-based modeling, and cutting-edge AI/ML approaches.

The successful candidate will directly contribute to active discovery programs while also leading the implementation of  AI tools across the discovery organization. The Executive Director will serve as both a scientific driver and a platform builder, partnering closely with Medicinal Chemistry, Biology, Structural Biology, and executive leadership to accelerate pipeline progression.

Key ResponsibilitiesScientific & Strategic Leadership

Define and execute computational chemistry strategy from target validation through candidate nomination.

Lead structure-based drug design efforts to enable hit identification and lead optimization. 

Identify, evaluate, and deploy AI tools across medicinal chemistry, biology, DMPK, and translational research.

Hands-On Drug Design

Personally contribute to programs using molecular docking, virtual screening, molecular dynamics, and free energy methods (FEP/TI).

Leverage structural biology data (X-ray, cryo-EM, homology models, AlphaFold) to guide rational design.

Drive scaffold hopping, de novo design, and multi-parameter optimization strategies.

Implement generative chemistry, predictive ADME/Tox models, and decision-support systems.

Promote AI adoption and literacy across the R&D organization.

Requirements

Ph.D. in Computational Chemistry, Biophysics, Chemical Physics, or related discipline.

5-20 years of industry experience supporting small-molecule drug discovery.

Demonstrated success partnering with medicinal chemistry programs that have advanced into clinical development

Deep expertise in SBDD, docking, molecular dynamics, FEP, and cheminformatics.

Strong working knowledge of AI/ML applications in molecular design, generative chemistry, and predictive modeling.

Hands-on leader who remains scientifically engaged.

Strong cross-functional collaborator with executive presence.

Passionate about building AI-enabled drug discovery platforms that deliver transformative therapeutics.

Apply