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Target Modeling Jobs in Houston, TX (NOW HIRING)

TG Natural Resources

Staff Geologist

Houston, TX

This role delivers high-quality geological models, actionable development recommendations, and ... target updates to ensure accurate well placement. Integrate drilling events, mud log shows, gas ...

TGNR HOLDCO LLC

Sr. Staff Geologist

Houston, TX · On-site

This role delivers high-quality geological models, actionable development recommendations, and ... target updates to ensure accurate well placement. Integrate drilling events, mud log shows, gas ...

Unavailable

Enterprise Data Architect

Houston, TX · On-site

Define and lead the enterprise data architecture strategy, target-state roadmap, and modernization ... Establish enterprise standards (approach, tooling, workflow) for data modeling, metadata management ...

New

Group 1 Automotive, Inc.

FP&A Analyst

Houston, TX · On-site

Own the financial modeling that supports M&A target valuation, accretion/dilution analysis, and pro forma impact on consolidated company performance * Build and maintain integrated three-statement ...

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Pediatrics - Neurology NRI (Instructor)

Pediatrics - Neurology NRI (Instructor)

Baylor College of Medicine

Houston, TX • On-site

Full-time

Posted 4 days ago

Baylor College of Medicine rating

8.6

Company rating: 8.6 out of 10

Based on 21 frontline employees who took The Breakroom Quiz

52nd of 539 rated colleges and universities

Job description

Summary

We are seeking a highly motivated and innovative Gene Editing Scientist to join a multidisciplinary team focused on developing cutting-edge human models of disease and advancing translational applications in neurodevelopmental and neurodegenerative disorders. The successful candidate will lead and execute genome engineering strategies across a range of platforms, including human induced pluripotent stem cells (iPSCs), 2D human brain models, and organoids. This position offers a unique opportunity to contribute to transformative discoveries at the intersection of gene editing and human disease modeling.

Job Duties
  • Design, develop, and optimize genome editing strategies using CRISPR/Cas systems (e.g., CRISPR-Cas9, base editing, prime editing)
  • Generate and validate genetically modified cell lines, including iPSCs and differentiated neural cell types
  • Perform clonal selection, screening, and molecular validation (PCR, sequencing, off-target analysis)
  • Collaborate with cross-functional teams (genetics, bioinformatics, cell biology, electrophysiology) to integrate multi-omics and functional data
  • Maintain detailed experimental records and contribute to publications, grant applications, and presentations
  • Stay current with emerging genome editing technologies and implement innovative approaches
  • Ensure compliance with institutional biosafety and regulatory guidelines
Minimum Qualifications
  • Ph.D. in Molecular Biology, Genetics, Neuroscience, Bioengineering, or related
  • field
  • 3+ years of hands-on experience in genome editing, particularly CRISPR-based
  • approaches
  • Demonstrated expertise in mammalian cell culture, including stem cells (iPSCs
  • preferred)
  • Experience with cloning, vector design, and delivery systems (viral and non-viral)
  • Strong background in molecular biology techniques (PCR, qPCR, NGS, Western
  • blotting)
  • Experience with clonal isolation and validation of edited lines
  • Ability to design experiments independently and troubleshoot complex protocols
  • Strong organizational, analytical, and communication skills

Preferred Qualifications

  • Experience with advanced genome editing technologies (base editing, prime editing, epigenome editing)
  • Familiarity with iPSC-derived models including organoid systems or 3D cell culture models
  • Experience working with neurological or developmental disease models
  • Knowledge of off-target analysis and genome-wide screening approaches
  • Experience with automation/robotics platforms for cell engineering workflows
  • Bioinformatics skills related to sequence analysis

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

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